CAS: 24807-55-4; 3-Nitro-1H-1,2,4-Triazole

该化合物是一种环形异环化合物,其特征为三硝基环结构,含有三个氮原子和两个碳原子.三硝基苯环的三处位置存在硝基化合物(-NO2),有助于其化学反应和潜在应用.这种化合物一般是晶状固体,在正常条件下因其稳定性而闻名,尽管它可能对热和冲击十分敏感,而热和冲击是硝基替代化合物的一个常见特征. 3-硝基-1,2,4-三硝基苯经常用于高能材料领域,特别是推进剂和爆炸物,因为其能够在分解时释放能量.此外,它也可以作为各种药品和农用化学合成的中间体.其溶性因溶剂不同而不同,在红外光谱谱谱和核磁共振反应等技术中可能表现出特定的光谱特性,协助实验室的鉴定和分析.

结构式图片

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CAS号61-82-5 3-氨基-1,2,4-三唑 | CAS号7664-93-9 硫酸 | CAS号36899-13-5 potassium salt ... | CAS号81911-06-0 bis(3-nitro-1H-... | CAS号81606-82-8 2-(3-nitro-1H-1... | CAS号70965-24-1 1H-1,2,4-Triazo... | CAS号26621-45-4 1-甲基-3-硝基-1H-1,... | CAS号71-43-2 苯 | CAS号133157-99-0 1-Chloro-3-nitr... | CAS号74205-83-7 (9ci)-3-硝基-1H-1... | CAS号26621-29-4 1-methyl-5-nitr... | CAS号26621-31-8 4H-1,2,4-Triazo... | CAS号26621-45-4 1-甲基-3-硝基-1H-1,... | CAS号24806-95-9 1H-1,2,4-Triazo... | CAS号6818-99-1 3-氯-1,2,4-三氮唑 | CAS号74257-00-4 1-(均三甲苯基-2-砜基)-... | CAS号7343-33-1 3-溴-1H-1,2,4-三氮唑 | CAS号129053-61-8 (9ci)-1-乙酰基-3-硝... | CAS号1001067-09-9 3-硝基-1H-1,2,4-三... | CAS号70965-24-1 1H-1,2,4-Triazo...

合成工艺路线路线简述

    Potassium Salt Of 3-Nitro-1,2,4-Triazole置于二氟代氙体系中,用 乙腈 用作溶剂,化学反应 30.0H,反应生成3-硝基-1,2,4-三氮唑
    参考文献:Reaction Of The 3-Nitrotriazole Anion With Xenon Difluoride
    标题:Reaction Of The 3-Nitrotriazole Anion With Xenon Difluoride
    摘要:
    Doi:10.1007/bf00958078

    海关参考信息

    专利信息


    专利号:US-4780504-A
    优先权日:1985-06-20
    标 题 :Supports useful in solid phase synthesis of oligonucleotides
    发明人:BUENDIA JEAN; NIERAT JEANINE
    权利人:ROUSSEL UCLAF
    摘要:Novel supports useful in solid phase synthesis of oligonucleotides of the formula I +TR wherein &cir& is micro pellets of a material selected from the group consisting of glass, silica, Kieselguhr, polytetrafluoroethylene, cellulose and metallic oxides, m is an integer from 1 to 20, A is selected from the group consisting of alkylene of 1 to 20 carbon atoms, saturated cycloalkylene of 3 to 12 carbon atoms, phenyl and 5 to 6 member heterocycles, x is an integer from 0 to 20, x1 is an integer from 0 to 10 and the amino group may be in the m-, p- or o-position, a process for the preparation of said supports, the use of said supports and intermediates.

    专利号:WO-2024163644-A1
    优先权日:2023-02-01
    标题:Belt reactor manufacturing process for oligomer synthesis
    发明人:KELLER KARSTEN; HILLEBRAND ROMAN
    权利人:ARROWHEAD PHARMACEUTICALS INC
    摘要:A method and apparatus for synthesis of oligomers such as oligonucleotides and peptides are disclosed. The method employs a device including at least one deprotection station to carry out a step of deprotection, at least one coupling station to carry out a step of coupling, optionally, one or more oxidation and/or thiolation stations to carry out a step of oxidation or thiolation, optionally, one or more capping stations to carry out a step of capping, and, optionally, one or more washing stations to carry out a step of washing. A plurality of solid phase material for oligomer synthesis is moved to the stations via a conveyor device, wherein a fluid delivery device acts upon said solid phase material to produce an oligomer.

    专利号:US-6340749-B1
    优先权日:1995-10-06
    标题:Preparation of nucleoside phosphoramidites and oligonucleotide synthesis
    发明人:ZHANG ZHAODA; TANG JIN-YAN
    权利人:AVECIA BIOTECHNOLOGY INC
    摘要:The invention provides novel bifunctional phosphitylating reagents and their application in in situ preparation of 5'-protected nucleoside phosphoramidites and synthesis of oligonucleotides. Bifunctional phosphitylating reagents according to the invention react quickly with nucleosides under neutral or weakly basic conditions, without an additional activation step. In addition, the bifunctional phosphitylating reagents according to the invention generate chemoselectively the corresponding nucleoside phosphoramidites in situ, without need to purify the nucleoside phosphoramidites before using them in oligonucleotide synthesis. Finally, the bifunctional phosphitylating reagents according to the invention are relatively stable and easy to handle.

    专利号:US-5902878-A
    优先权日:1989-05-24
    标 题 :Modified phosphoramidite process for the production of modified nucleic acids
    发明人:SELIGER HEINZ-HARTMUT; BERNER SIBYLLE; MUEHLEGGER KLAUS; VON DER ELTZ HERBERT; BATZ HANS-GEORG
    权利人:BOEHRINGER MANNHEIM GMBH
    摘要:The subject matter of the invention is a modified phosphoramidite process for the synthesis of nucleotide sequences. By use of a modified nucleoside phosphoramidite it is possible to produce nucleotide sequences which have a modified phosphate residue.

    专利号:US-7776169-B2
    优先权日:2005-06-01
    标 题 :Water-based synthesis of poly(tetrazoles) and articles formed therefrom
    发明人:MILLER CORY G; WILLIAMS GRAYLON K
    权利人:AUTOMOTIVE SYSTEMS LAB
    摘要:A polyvinyl(tetrazole) is formed by a water-based method. A gas generating composition 12 containing the polyvinyl(tetrazole) is contained within an exemplary gas generator 10 . An article or gas generating system 200 incorporates the polyvinyl(tetrazole) therein. A vehicle occupant protection system 180 incorporates the gas generating system 200 . An article or substrate 300 containing a coating 302 formed from the product of the water-based method is also described.

    专利号:US-12269839-B2
    优先权日:2017-06-30
    标题 :Chiral phosphoramidite auxiliaries and methods of their use
    发明人:SAKAMURI SUKUMAR; BRADSHAW CURT W; LIU DINGGUO; ELTEPU LAXMAN
    权利人:SIRIUS THERAPEUTICS INC
    摘要:Disclosed are P-stereogenic groups that may be used in the synthesis of compounds including stereochemically enriched P-stereogenic phosphorothioates. P-stereogenic groups may be provided in nucleoside phosphoramidites including a sugar bonded to a nucleobase and to a stereochemically enriched phosphoramidite as well as methods of their use and methods of making them.
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    合成参考文献


    参考文献:10.1016/j.jinorgbio.2006.07.001
    摘要:Kennedy DC, Wu A, Patrick BO, James BR. Ruthenium(III) maltolato-nitroimidazole complexes: Synthesis and biological activity. Journal of Inorganic Biochemistry. 2006 Dec;100(12):1974–82. doi: 10.1016/j.jinorgbio.2006.07.001.
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