CAS: 21738-42-1; Oxamniquine
- 英文名称Oxamniquine
- 中文名称硝羟四氢喹啉胺
- IUPAC名称(2-((isopropylamino)methyl)-7-nitro-1,2,3,4-tetrahydroquinolin-6-yl)methanol
- 其它别名6-Quinolinemethanol,1,2,3,4-tetrahydro-2-[(isopropylamino)methyl]-7-nitro- (8CI); (?à)-Oxamniquine; 1,2,3,4-Tetrahydro-6-(hydroxymethyl)-2-[(isopropylamino)methyl]-7-nitroquinoline; 6-Hydroxymethyl-2-isopropylaminomethyl-7-nitro-1,2,3,4-tetrahydroquinoline; Mansil; Oxamniquine; Vansil
- CAS编号21738-42-1
- MFCD编号:MFCD00866725
- EINECS号:244-556-4
- 分子式:C14H21N3O3分子量:279.34
- 产品CID: 1133160
- 产品分类原料药 → 抗寄生虫病药 → 抗吸虫病药
物理性质
- 熔点147-149 °C
- 沸点443.6 °C at 760mmHg
- 闪点222.1 °C
- 密度1.174g/cm3
- pKa:pKa 3.28 ± 0.07;9.53(H2O,t =25) (Uncertain)
- PSA:90.11
- LogP:2.8639
- 折射率1.56
- 蒸汽压1.19E-08mmHg at 25°C
- 溶解性DMSO (Slightly), Methanol (Slightly)
- 外观形态浅橙色粉末固体
- 储存条件Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
MSDS等安全信息
欧盟法规
ECHA物质C&L通报REACH预注册合成工艺路线路线简述
📜Oxamniquine Aldehyde,硼氢化钠 反应生成硝羟四氢喹啉胺
参考文献:El-Hamouly,Wageeh;Pica-Mattoccia,Livia;Cioli,Donato;Schwartz,Herbert +,J. Med. Chem.,31,(1988) N 8,1629-1631
标题:El-Hamouly,Wageeh;Pica-Mattoccia,Livia;Cioli,Donato;Schwartz,Herbert +,J. Med. Chem.,31,(1988) N 8,1629-1631
海关参考信息
- 2902600000-乙苯
2905110000-甲醇
2906210000-苄醇
2921211000-乙二胺 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
1: González Cabrera D, Keiser J, Spangenberg T. Analysis of the Physicochemical Properties of Anti-Schistosomal Compounds to Identify Next-Generation Leads. ACS Med Chem Lett. 2024 Apr 25;15(5):626-630. doi: 10.1021/acsmedchemlett.4c00026.
2: Anyubaga SB, Shallangwa GA, Uzairu A, Abechi SE. Chemo-informatics applications in the design of novel 7-keto-sempervirol derivatives as SmCB1 inhibitors with potential for treatment of Schistosomiasis. Heliyon. 2023 Dec 3;10(1):e23115. doi: 10.1016/j.heliyon.2023.e23115.
3: Pfarr KM, Krome AK, Al-Obaidi I, Batchelor H, Vaillant M, Hoerauf A, Opoku NO, Kuesel AC. The pipeline for drugs for control and elimination of neglected tropical diseases: 2. Oral anti-infective drugs and drug combinations for off- label use. Parasit Vectors. 2023 Oct 31;16(1):394. doi: 10.1186/s13071-023-05909-8.
合成参考文献
合成方法参考DOI号:10.1021/jm00293a004
📝 需求与反馈
尽可能描述清楚需求与问题信息
