CAS: 211914-50-0; Ethyl 3-[[2-[(4-Carbamimidoylanilino)Methyl]-1-Methylbenzimidazole-5-Carbonyl]-Pyridin-2-Ylamino]Propanoate,Hydrochloride

4-氯-3-硝基苯甲酸置于盐酸,氯化亚砜,Palladium On Activated Charcoal,N,N-二甲基甲酰胺,N,N'-羰基二咪唑体系中,用 乙醇,乙酸乙酯,甲苯 用作溶剂,化学反应 20.4H,反应生成N-[[2-[[[4-(氨基亚氨基甲基)苯基]氨基]甲基]-1-甲基-1H-苯并咪唑-5-基]羰基]-N-(2-吡啶)-Beta-丙氨酸乙酯盐酸盐
参考文献:Process For The Preparation Of Dabigatran Etexilate Mesylate And Polymorphs Of Intermediates Thereof
标题:Process For The Preparation Of Dabigatran Etexilate Mesylate And Polymorphs Of Intermediates Thereof
摘要:本发明提供了formula 2A的中间体的晶型,本发明还提供了达比加群酯甲磺酸盐的制备方法;其中间体的多形态;尤其是制备中间体晶型的方法.本发明还涉及使用晶体中间体制备达比加群酯甲磺酸盐.

专利信息

专利号:US-9365544-B2
优先权日:2012-07-16
标题 :Process for the preparation of intermediates for the synthesis of Dabigatran Etexilate, and crystalline forms of said intermediates
发明人：HERNÀNDEZ GALLEGO SANTOS; MARQUILLAS OLONDRIZ FRANCISCO; POMARES MARCO MARTA
权利人:INTERQUIM SA
摘要:The present invention relates to new processes for the preparation of synthesis intermediate products useful in the preparation of Dabigatran Etexilate on an industrial scale. The invention also relates to new crystalline forms of intermediate products thus obtained.

专利号:US-9273030-B2
优先权日:2012-04-02
标题 :Process for the preparation of benzimidazole derivatives and salts thereof
发明人：THIRUMALAI RAJAN SRINIVASAN; ESWARAIAH SAJJA; RAGHURAM SURAPARAJU
权利人:MSN LAB PRIVATE LTD
摘要:Provided are novel salts of benzimidazole derivatives, preferably salts of benzimidazole derivatives which are useful intermediates in the synthesis of pure 1-methyl-2-[N-[4-(N-n-hexyloxycarbonylamidino)phenyl]aminomethyl]benzimidazol-5-yl-carboxylicacid-N-(2-pyridyl)-N-(2-ethoxycarbonylethyl)amide and its salts.

专利号:US-2015203470-A1
优先权日:2012-07-16
标 题 :Process for the preparation of intermediates for the synthesis of dabigatran etexilate, and crystalline forms of said intermediates

专利号:EP-2872499-A1
优先权日:2012-07-16
标 题 :Process for the preparation of intermediates for the synthesis of dabigatran etexilate, and crystalline forms of said intermediates

专利号:WO-2014012880-A1
优先权日:2012-07-16
标题 :Process for the preparation of intermediates for the synthesis of dabigatran etexilate, and crystalline forms of said intermediates