CAS: 20263-07-4; 2 Apb

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2-Amino-4-(dimethoxy-phosphoryl)-butyric acid methyl ester

专利信息

专利号:US-2024391961-A1
优先权日:2021-08-25
标题:Autonomous organisms for synthesis of permanently phosphorylated proteins
发明人：COOLEY RICHARD B; MEHL RYAN A; ZHU PHILLIP
权利人:UNIV OREGON STATE
摘要:Embodiments of the present disclosure provide compositions and methods for biosynthesizing a stable, functional mimic of phosphoserine. The compositions and methods described herein genetically program a host cell to express a biosynthetic pathway that can synthesize the amino acid, 2-amino-4-phosphobobutyric acid, that is a non-hydrolyzable phosphoserine (nhpSer) because it contains a carbon-phosphorus, e.g., phosphonate, bond. In one embodiment the genetically programed cells express the enzymes of a pathway from a Streptomyces bacterium . In some embodiments, nhpSer is translationally incorporated into protein of interest at one or more programmed UAG amber codons using Genetic Code Expansion (GCE) technology.

专利号:US-7060818-B2
优先权日:2003-02-21
标题:Synthesis of macrocyclic tetraamido compounds and new metal insertion process
发明人：HORWITZ COLIN P; GHOSH ANINDYA
权利人:UNIV CARNEGIE MELLON
摘要:An improved method of synthesizing a macrocyclic tetraamido compound includes protecting the amino portion of an amino carboxylic acid to form a protected amino carboxylic acid; exposing the protected amino carboxylic acid to a first solvent, preferably a hydrocarbon solvent, such as toluene or 1,2-dichloroethane, dichloromethane, dibromomethane and 1,2-dibromoethane. The carboxylic acid portion of the protected amino carboxylic acid is then converted to an activated carboxylic acid by one of esterification or acid halide formation, to form a protected amino activated carboxylic acid derivative. The protected amino activated carboxylic acid derivative is reacted with a diamine in the presence of a second solvent, such as THF or ,2-dichloroethane, dichloromethane, dibromomethane and 1,2-dibromoethane, to form a protected diamide diamine intermediate. Following deprotection, the diamide diamine intermediate is reacted with an activated diacid, such as an activated malonate, oxalate or succinate derivative to form the macrocyclic tetraamido compound. The macrocyclic tetraamido compound may further be complexed with a transition metal.

专利号:US-6245919-B1
优先权日:1996-06-28
标 题:Cyclopropylglycine derivatives and agonists for metabotronic L-glutamate receptors
发明人：SHINOZAKI HARUHIKO; TAGUCHI TAKEO; ISHIDA MICHIKO
权利人:SHINOZAKI HARUHIKO; TAGUSHI TAKEO; NIPPON CHEMIPHAR CO
摘要:A cyclopropylglycine derivative having the following formula:and an intermediate compound for the synthesis of the cyclopropylglycine derivative are novel compounds. The cyclopropylglycine derivative shows a selectivity higher than that of the known agonists to metabotropic L-glutamate receptors, and therefore is a metabotropic type agonist to L-glutamate which has excellent characteristics.

专利号:WO-2023028563-A1
优先权日:2021-08-25
标题 :Autonomous organisms for synthesis of permanently phosphorylated proteins

专利号:US-2012190648-A1
优先权日:2009-07-23
标 题:Fluorinated cyclopropane analogs of glutamic acid
发明人：JUBAULT PHILIPPE; QUIRION JEAN-CHARLES; LEMONNIER GERALD; LION CEDRIC
权利人:JUBAULT PHILIPPE; QUIRION JEAN-CHARLES; LEMONNIER GERALD; LION CEDRIC
摘要:The present invention relates to a compound of formula (I) or a pharmaceutically acceptable salt, a stereoisomer or a mixture in all proportions of stereoisomers thereof, in particular a mixture of enantiomers, such as a racemic mixture, wherein R represents a (C 1 -C 6 )alkyl or (C 1 -C 6 )alkenyl group, optionally substituted by one or more groups chosen among an halogen atom, OR a , SR b , NR c R d , PO(OR e )(OR f ), CO 2 R g , SO 2 R h SO 3 R 1 , P0(0H)(CH(0H)R k ), CN, N 3 and NH—C(â•?NH)NH2, with R a , R b , R c and R d , representing, independently of each other, an hydrogen atom, a (C 1 -C 6 )alkyl group or a —CO—(C 1 -C 6 )alkyl group, R e , R f , R g , R h and R1 representing, independently of each other, an hydrogen atom or a (C 1 -C 6 )alkyl group, and R k representing an aryl or heteroaryl group, said group being optionally substituted by one or more groups selected from an halogen atom and NO 2 , as well as to the use thereof and to a process for preparing such a compound, to a pharmaceutical composition containing it and to synthesis intermediates.

专利号:US-6011152-A
优先权日:1996-07-22
标 题 :Synthesis of macrocyclic tetraamido-N ligands