专利号:US-7429658-B2 优先权日:2003-09-11 标题 :Synthesis of protected pyrrolobenzodiazepines 发明人:HOWARD PHILIP; MASTERSON LUKE 权利人:SPIROGEN LTD 摘要:A method of synthesis of a N-10 protected PBD compound of formula (I): n nvia an intermediate of formula (II) or formula (V):
专利号:US-7888505-B2 优先权日:2006-01-13 标 题:6,7-dihydrobenzimidazo[1,2-c]quinazolin-6-one carboxylic acids, their esters, and methods of synthesis thereof 发明人:DOUTOVA TATYANA; LAZAREV PAVEL I; SIDORENKO ELENA N; KUZMIN VALERY S 权利人:CRYSOPTIX KK 摘要:The present invention relates to a 6,7-dihydrobenzimidazo[1,2-c]quinazolin-6-one carboxylic acid and its esters of the general structural formula (I), and provides a method for their synthesis (I) where R and each R′ are selected independently from the list comprising —H—CH 3 , —C 2 H 5 , —C 3 H 7 , -iso-C 3 H 7 , —CH 2 CH 2 CH 2 CH 3 , —CH(CH 3 )CH 2 CH 3 , —CH 2 CH(CH 3 )CH 3 and —C(CH 3 ) 3 ; n is 1, 2, 3 or 4; Y is a substituent selected from the list comprising —CH 3 , —C 2 H 5 , —NO 2 , —Cl, —Br, —F, —CF 3 , —CN, —OH, —OCH 3 , —OC 2 H 5 , —OCOCH 3 , —OCN, —SCN, —NH 2 , —NHCOCH 3 ; and z is 0, 1, 2, 3 or 4.
专利号:US-6531470-B1 优先权日:1998-01-23 标题:Oxazolidinone combinatorial libraries, compositions and methods of preparation 发明人:GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V; NI ZHI-JIE; GORDON ERIC 权利人:UPJOHN CO 摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.
专利号:US-6562844-B2 优先权日:1998-01-23 标 题:Oxazolidinone combinatorial libraries, compositions and methods of preparation 发明人:GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V; NI ZHI-JIE; GORDON ERIC 权利人:UPJOHN CO 摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.
专利号:RU-2141321-C1 优先权日:1994-03-04 标题:Use of imidazole derivatives for preparing pharmaceutical composition showing activity to angiotensin receptors at1 and at2, some of these compounds, method of synthesis of imidazole derivatives and pharmaceutical composition based on thereof
专利号:US-2006264622-A1 优先权日:2003-09-11 标题 :Synthesis of protected pyrrolobenzodiazepines
参考文献:10.1007/s12272-013-0091-9 摘要:Jahng Y. Progress in the studies on tryptanthrin, an alkaloid of history. Archives of Pharmacal Research. 2013 Mar 31;36(5):517–35. doi: 10.1007/s12272-013-0091-9. 参考文献:10.1007/s11172-023-4108-3 摘要:Valieva MI, Rybakova SS, Kudryashova EA, Rahman M, Santra S, Kopchuk DS, Nosova EV, Gorbunov EB, Zyryanov GV, Chupakhin ON. Cyclocondensation of anthranilic acids with generated in situ methyl pyrimidine-2-carbimidate in the synthesis of 2-(pyrimidin-2-yl)quinazolin-4(3H)-ones. Russ Chem Bull. 2023 Dec;72(12):2974–8. doi: 10.1007/s11172-023-4108-3.