CAS: 1256584-73-2; 2-(4-Ethyl-3-Iodophenyl)-2-Methylpropanoic Acid

相似化合物

1247119-83-0 1175538-69-8 144759-97-7

上下游产品

2-(4-Ethylphenyl)-2-Methylpropionic Acid
Alpha,Alpha-二甲基苯乙酸 2-Methyl-2-Phenylpropionic Acid 826-55-1
2-(4-乙基苯基)-2-甲基丙酸甲酯 Methyl 2-(4-Ethylphenyl)-2-Methyl-Propanoate 698394-59-1
2-(4-乙酰苯基)-2,2-二甲基-乙酸 2-(4-Acetyl-Phenyl)-2-Methyl-Propionic Acid 857768-18-4
2,2-二甲基苯乙酸甲酯 Methyl 2-Methyl-2-Phenylpropionate 57625-74-8

2-(4-乙基苯基)乙酸置于n-碘代丁二酰亚胺,硫酸,Sodium Hydride,溶剂黄146体系中,用 N,N-二甲基甲酰胺 用作溶剂,化学反应生成艾乐替尼中间体
参考文献:一种艾乐替尼中间体的制备方法
标题:一种艾乐替尼中间体的制备方法
摘要:本发明公开了一种艾乐替尼中间体2‑(4‑乙基‑3‑碘)苯基‑2‑甲基丙酸的制备方法,本发明制备方法通过优化改进制备路线方法,优化反应条件,改善后处理及纯化方法,降低了操作危险等级和生产成本;对反应用容器设备的抗腐蚀等级要求低,操作安全性好,后处理绿色环保,得到的艾乐替尼中间体2‑(4‑乙基‑3‑碘)苯基‑2‑甲基丙酸杂质含量低,在提高收率的同时大大提高了中间体产品的纯度和质量,改善了艾乐替尼原料药生产过程中工艺控制的难度和提高艾乐替尼的原料药质量和合格率;此制备方法各步骤操作简单,溶剂及工艺条件安全易行,实现了环保绿色生产,具有广阔的应用前景.

专利信息

专利号:WO-2019038779-A1
优先权日:2017-08-21
标 题:NEW PROCESS FOR PREPARING ALECTINIB INTERMEDIATE
发明人：APPAYE KALIYAPERUMAL SRINIVASAN; TALASANI SHYAM SUNDER REDDY; SAMATHAM NAGALINGAM; KONDURI SRINIVASA KRISHNA MURTHY; BUDIDETI SHANKAR REDDY; MUDDASANI PULLA REDDY; NANNAPANENI VENKAIAH CHOWDARY
权利人:NATCO PHARMA LTD
摘要:The present invention relates to a new process for the preparation of 2- (4-ethyl-3-iodophenyl) -2-methylpropanoic acid of formula (I), (I) which is a key intermediate in the synthesis of Alectinib or its salt of formula (II).

专利号:CN-109438218-B
优先权日:2018-10-23
标 题 :Synthesis method of hydrochloric acid neritinib intermediate 2- (4-ethyl-3-iodophenyl) -2-methylpropanoic acid