专利号:US-9115128-B2 优先权日:2013-06-06 标 题 :Compounds of 3-(5-substituted Oxy-2, 4-dinitrophenyl)-2-oxo-propionic acid ester, synthesis and applications thereof 发明人:PUTHIAPARAMPIL TOM THOMAS; SAMBASIVAM GANESH; GOVINDA RAJULU GAVARA; KORAMANGALA RAVINDRA CHANDRAPPA 权利人:ANTHEM BIOSCIENCES PVT LTD; ANTHEM BIOSCIENCES PVT LTD 摘要:Synthesis of the novel compound 3 (3-(5-substituted Oxy-2,4-dinitro-phenyl)-2-oxo-propionic acid ester) to make Pyrroloquinoline quinone (PQQ) and using it for pharmaceutical purposes is described. More specifically, this disclosure relates to synthesizing the PQQ in an efficient method by using a novel intermediate Formula 1 resulting in a shorter process and higher yield of PQQ. A unique process to make sodium compound of PQQ using either sodium hydroxide and/or sodium carbonate is also shown.
专利号:US-2014364613-A1 优先权日:2013-06-06 标题:Compounds of 3-(5-sustituted oxy-2, 4-dinitrophenyl)-2-oxo-propionic acid ester, synthesis and applications thereof