CAS: 114457-94-2; (S)-3-Phenyl-2-(Pyrazine-2-Carboxamido)Propanoic Acid

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CAS号19847-10-0 2-吡嗪羰酰氯 | CAS号63-91-2 L-苯丙氨酸 | CAS号73058-37-4 4-(8,9-二氢吡啶并[2,... | CAS号7364-51-4 N-(Trimethylsil... | CAS号103435-88-7 pyrazinecarboxy... | CAS号98-97-5 2-吡嗪羧酸 | CAS号16480-57-2 sodium,(2S)-2-a... | CAS号7524-50-7 L-苯丙氨酸甲酯盐酸盐 | CAS号2577-90-4 (S)-2-氨基-3-苯基丙酸甲酯 | CAS号179324-69-7 硼替佐米

L-苯基丙氨酸叔丁酯置于盐酸,N,N-二异丙基乙胺,N-[(Dimethylamino)-3-Oxo-1H-1,2,3-Triazolo[4,5-B]Pyridin-1-Yl-Methylene]-N-Methylmethanaminium Hexafluorophosphate体系中,用 1,4-二氧六环 用作溶剂,化学反应 16.08H,反应生成N-(2-吡嗪基羰基)-L-苯丙氨酸
参考文献:用于探测体外生物学的选择性lonp1抑制剂的基于结构的设计
标题:用于探测体外生物学的选择性lonp1抑制剂的基于结构的设计
摘要:Lonp1是一种aaa +蛋白酶,可通过去除受损或错误折叠的蛋白质来维持线粒体的体内平衡.Lonp1的活性和表达升高会促进癌细胞的增殖和对凋亡诱导剂的抗性.尽管lonp1在人类生物学和疾病中很重要,但文献中几乎没有描述过lonp1抑制剂.在这里,我们报告使用基于结构的药物设计以及结合各种抑制剂的人lonp1的第一个结构的选择性硼酸基lonp1抑制剂的发展.我们的努力导致了几种对20S蛋白酶体几乎没有活性的纳米摩尔lonp1抑制剂,它们是研究lonp1生物学的工具化合物.
Doi:10.1021/acs.Jmedchem.0C02152

专利信息

专利号:US-9862745-B2
优先权日:2004-03-30
标题 :Synthesis of boronic ester and acid compounds
发明人：AMMOSCATO VINCE; BISHOP JOHN E; CHIU FANG-TING; GEISER ACHIM; GOMEZ JEAN-MARC; HETT ROBERT; KOELLNER CHRISTOPH; KULKARNI VITHALANAND R; LO YOUNG; MUNK STEPHEN; PICKERSGILL I FRASER
权利人:MILLENNIUM PHARM INC; MILLENNIUM PHARM INC
摘要:The invention relates to the synthesis of boronic ester and acid compounds. More particularly, the invention provides improved synthetic processes for the large-scale production of boronic ester and acid compounds, including the peptide boronic acid proteasome inhibitor bortezomib.

专利号:US-2018265546-A1
优先权日:2004-03-30
标题 :Synthesis of boronic ester and acid compounds

专利号:US-2005240047-A1
优先权日:2004-03-30
标 题:Synthesis of boronic ester and acid compounds

专利号:CN-111925385-A
优先权日:2004-03-30
标题 :Synthesis of Boron Ester and Acid Compounds

专利号:US-2020157143-A1
优先权日:2004-03-30
标题 :Synthesis of boronic ester and acid compounds

专利号:US-10000529-B2
优先权日:2004-03-30
标题:Synthesis of boronic ester and acid compounds