专利号:US-2008103312-A1 优先权日:2006-08-29 标 题:Processes for the synthesis of 5-phenyl-1-trityl-1H-tetrazole 发明人:KANSAL VINOD K; MISTRY DHIRENKUMAR N; VASOYA SANJAY L; LUNAGARIYA VIJAYKUMAR D 权利人:KANSAL VINOD K; MISTRY DHIRENKUMAR N; VASOYA SANJAY L; LUNAGARIYA VIJAYKUMAR D 摘要:Provided are processes for the synthesis of 5-phenyl-1-trityl-1H-tetrazole, an intermediate useful in the synthesis of irbesartan.
专利号:US-2002042514-A1 优先权日:2000-06-26 标 题 :Synthesis of chlorinated pyrimidines 发明人:DOYLE TIMOTHY JOHN; WEHRENBERG PETER KARL; STANDEN MICHAEL CHARLES HENRY 摘要:A facile process for the preparation of 4,6-dichloropyrimidine is provided, which utilizes quaternary ammonium salts or quaternary phosphonium salts as catalysts for the reaction of, for example, 4,6-dihydroxypyrimidine or 4-chloro-6-methoxypyrimidine with phosgene.
专利号:EP-0830136-B1 优先权日:1995-03-07 标 题:New cryptophycins from synthesis 发明人:MOORE RICHARD E; TIUS MARCUS A; BARROW RUSSELL A; LIANG JIAN; CORBETT THOMAS H; VALERIOTE FREDERICK A; HEMSCHEIDT THOMAS K; GOLAKOTI TRIMURTULU 权利人:UNIV HAWAII; UNIV WAYNE STATE 摘要:Novel cryptophycin compounds are disclosed, together with methods of producing cryptophycins by total synthesis and methods for the use of such cryptophycins in pharmaceuticals to inhibit the proliferation of mammalian cells and to treat neoplasia.
专利号:US-6204361-B1 优先权日:1996-01-18 标 题 :Method of peptide synthesis 发明人:CARPINO LOUIS A; IONESCU DUMITRU 权利人:RES CORP TECHNOLOGIES INC 摘要:The present invention relates to a process for forming an N-α-amino protected amino acid fluoride in situ by reacting an N-α-amino protected amino acid with an ionic fluoride salt in the presence of a peptide coupling agent. It is also directed to the use of the amino acid fluoride thus formed in peptide synthesis.
专利号:US-6013626-A 优先权日:1993-12-21 标题 :Cryptophycins from synthesis 发明人:MOORE RICHARD E; TIUS MARCUS A; BARROW RUSSELL A; LIANG JIAN; CORBETT THOMAS H; VALERIOTE FREDERICK A; GOLAKOTI TRIMURTULU; HEMSCHEIDT THOMAS K 权利人:UNIV HAWAII; UNIV WAYNE STATE 摘要:A cryptophycin compound is provided having the structure: ##STR1## Further provided are methods of producing cryptophycins by total synthesis and methods of using cryptophycins in pharmaceuticals. It is a further object of this invention to use cryptophycins to inhibit the proliferation of mammalian cells. Moreover, methods of using cryptophycins to treat neoplasia is also provided.
专利号:US-8809585-B2 优先权日:2004-10-02 标 题:Synthesis scheme for lacosamide 发明人:RIEDNER JENS; DUNNE GAVIN 权利人:RIEDNER JENS; DUNNE GAVIN; UCB PHARMA GMBH 摘要:The present invention is concerned with an improved method of producing (R)-2-acetamido-N-benzyl-3-methoxypropionamide (lacosamide) comprising the 0-methylation of a compound of formula (I) to produce a compound of formula (II) in a single step reaction.