CAS: 109838-85-9; (R)-2-Isopropyl-3,6-Dimethoxy-2,5-Dihydropyrazine

相似化合物

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上下游产品

CAS号420-37-1 三甲基氧鎓四氟硼酸 | CAS号143673-66-9 (R)-3-异丙基哌嗪-2,5-二酮 | CAS号1685-33-2 CBZ-D-缬氨酸 | CAS号32402-31-6 N-benzyloxycarb... | CAS号640-68-6 D-缬氨酸 | CAS号22838-58-0 B°C-D-缬氨酸 | CAS号850312-86-6 methyl N-(tert-... | CAS号640-68-6 D-缬氨酸 | CAS号7146-15-8 D-缬氨酸甲酯盐酸盐

D-缬氨酸置于碳酸氢钠,三乙胺体系中,用 四氢呋喃,二氯甲烷,水,邻二氯苯 用作溶剂,化学反应 137.5H,反应生成(R)-2,5-二氢-3,6-二甲氧基-2-异丙基吡嗪
参考文献:所述schöllkopf手性助剂的一种改进的大规模合成:(2-[r )-和(2小号)-2,5-二氢-3,6-二甲氧基-2-异丙基吡嗪
标题:所述schöllkopf手性助剂的一种改进的大规模合成:(2-[r )-和(2小号)-2,5-二氢-3,6-二甲氧基-2-异丙基吡嗪
摘要:Schöllkopf手性助剂的合成已经大规模进行,从d-和l-缬氨酸的总收率很高.此方法避免使用剧毒的光气或三光气,低温反应和不稳定的中间体.
Doi:10.1021/op049777T

专利信息

专利号:US-8487108-B2
优先权日:2005-11-14
标题 :Piperidinyl carbamate intermediates for the synthesis of aspartic protease inhibitors
发明人：BALDWIN JOHN J; CLAREMON DAVID A; TICE COLIN; CACATIAN SALVACION; DILLARD LAWRENCE W; ISHCHENKO ALEXEY V; YUAN JING; XU ZHENRONG; MCGEEHAN GERARD; SIMPSON ROBERT D; SINGH SURESH B; ZHAO WEI; FLAHERTY PATRICK T
权利人:BALDWIN JOHN J; CLAREMON DAVID A; TICE COLIN; CACATIAN SALVACION; DILLARD LAWRENCE W; ISHCHENKO ALEXEY V; YUAN JING; XU ZHENRONG; MCGEEHAN GERARD; SIMPSON ROBERT D; SINGH SURESH B; ZHAO WEI; FLAHERTY PATRICK T; VITAE PHARMACEUTICALS INC
摘要:The present invention is directed to aspartic protease inhibitors. Certain aspartic protease inhibitors of the invention can be represented by the following structural formula or a pharmaceutically acceptable salt thereof. The present invention is also directed to pharmaceutical compositions comprising the disclosed aspartic protease inhibitors. The present invention is further directed to methods of antagonizing one or more aspartic proteases in a subject in need thereof, and methods for treating an aspartic protease mediated disorder in a subject using the disclosed aspartic protease inhibitors.

专利号:CN-118146253-A
优先权日:2024-04-09
标 题 :Synthesis of a Silicon-Nitrogen Five-Membered Heterocyclic Chiral Alcohol