CAS: 10166-54-8; 1-Methyltetrahydropyrimidin-2(1H)-One

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131056-76-3 7226-23-5 1955530-48-9

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CAS号201230-82-2 carbon monoxide | CAS号6291-84-5 3-甲氨基丙胺 | CAS号530-62-1 N,N'-羰基二咪唑(CDI) | CAS号124-38-9 二氧化碳 | CAS号57-13-6 尿素 | CAS号343926-83-0 Carbamodithioic...

📜(3-Amino-Propyl)-Methyl-Dithiocarbamic Acid置于盐酸,Sodium Hydroxide,双氧水体系中,用 乙醇 用作溶剂,化学反应 10.5H,反应生成1-甲基四氢嘧啶-2(1H)-酮
参考文献:环脲和硫脲衍生物可诱导鼠类红细胞白血病分化.
标题:环脲和硫脲衍生物可诱导鼠类红细胞白血病分化.
摘要:已经合成了一系列的四甲基脲衍生物,它是friend红白血病细胞分化的已知诱导剂,并通过血红蛋白的合成进行了测试,测试了其诱导红系成熟的能力.制备了由含有n-烷基取代基的五元,六元和七元环系统组成的环状脲和硫脲衍生物.这些药物大多数是相对有效的分化诱导剂,N-烷基取代似乎是最大反应所必需的.开发出的最有效的试剂是n,N'-二甲基环状脲.暴露于2至4 Mm的这些衍生物的浓度导致90%以上的细胞群体达到分化状态.在这些条件下,母体化合物四甲基脲的功效稍差,
Doi:10.1021/jm00141A015

专利信息

专利号:EP-1473330-B1
优先权日:1996-07-17
标题:Process for the synthesis of oxonol compound
发明人：NISHIGAKI JUNJI; DEGUCHI YASUAKI
权利人:FUJI PHOTO FILM CO LTD
摘要:An oxonol compound is represented by the following formula (I): in which each of Z, W<1> and W<2> independently is an atomic group that forms a heterocyclic ring; and M is a cation. A process for the synthesis of an oxonol compound is disclosed.

专利号:US-9481660-B2
优先权日:2006-10-02
标题 :Tetra-O-substituted butane-bridge modified NDGA derivatives, their synthesis and pharmaceutical use
发明人：HELLER JONATHAN DANIEL; CHEN QINGQI; LOPEZ ROCIO ALEJANDRA; MORRIS AMANDA JEAN
权利人:HELLER JONATHAN DANIEL; CHEN QINGQI; LOPEZ ROCIO ALEJANDRA; MORRIS AMANDA JEAN; ERIMOS PHARMACEUTICALS LLC
摘要:The present invention relates to nordihydroguaiaretic acid derivative compounds, namely, butane bridge modified nordihydroguaiaretic acid (NDGA) compounds and butane bridge modified tetra-O-substituted NDGA compounds, pharmaceutical compositions containing them, methods of making them, and methods of using them and kits including them for the treatment of diseases and disorders, in particular, diseases resulting from or associated with a virus infection, such as HIV infection, HPV infection, or HSV infection, an inflammatory disease, such as various types of arthritis and inflammatory bowel diseases, metabolic diseases, such as diabetes and hypertension, or a proliferative disease, such as diverse types of cancers.

专利号:US-8178527-B2
优先权日:2006-10-02
标 题 :Tetra-substituted NDGA derivatives via ether bonds and carbamate bonds and their synthesis and pharmaceutical use
发明人：CHEN QINGQI; LOPEZ ROCIO ALEJANDRA; HELLER JONATHAN DANIEL; MORRIS AMANDA JEAN
权利人:CHEN QINGQI; LOPEZ ROCIO ALEJANDRA; HELLER JONATHAN DANIEL; MORRIS AMANDA JEAN; ERIMOS PHARMACEUTICALS LLC
摘要:Disclosed are nordihydroguaiaretic acid derivative compounds including various end groups bonded by a carbon atom or heteroatom though a side chain bonded to the respective hydroxy residue O groups by an ether bond or a carbamate bond, pharmaceutical compositions, methods of making them, and methods of using them and kits including them for the treatment of diseases and disorders, in particular, diseases resulting from or associated with a virus infection, such as HIV infection, HPV infection, or HSV infection, an inflammatory disease, such as various types of arthritis and inflammatory bowel diseases, a metabolic disease, such as diabetes, a vascular disease, such as hypertension and macular degeneration, or a proliferative disease, such as diverse types of cancers.

专利号:US-9067875-B2
优先权日:2006-10-02
标 题 :Tetra-substituted NDGA derivatives via ether bonds and carbamate bonds and their synthesis and pharmaceutical use
发明人：CHEN QINGQI; LOPEZ ROCIO ALEJANDRA; HELLER JONATHAN DANIEL; MORRIS AMANDA JEAN
权利人:CHEN QINGQI; LOPEZ ROCIO ALEJANDRA; HELLER JONATHAN DANIEL; MORRIS AMANDA JEAN; ERIMOS PHARMACEUTICALS LLC
摘要:Disclosed are nordihydroguaiaretic acid derivative compounds including various end groups bonded by a carbon atom or heteroatom though a side chain bonded to the respective hydroxy residue O groups by an ether bond or a carbamate bond, pharmaceutical compositions, methods of making them, and methods of using them and kits including them for the treatment of diseases and disorders, in particular, diseases resulting from or associated with a virus infection, such as HIV infection, HPV infection, or HSV infection, an inflammatory disease, such as various types of arthritis and inflammatory bowel diseases, a metabolic disease, such as diabetes, a vascular disease, such as hypertension and macular degeneration, or a proliferative disease, such as diverse types of cancers.

专利号:US-2010317848-A1
优先权日:2006-12-31
标题:Process for the synthesis of derivatives of 3-amino-tetrahydrofuran-3-carboxylic acid and use thereof as medicaments

专利号:US-2008045718-A1
优先权日:2006-08-14
标题 :Process and intermediates for the synthesis of 2-(quinolin-5-yl)-4,5 disubstituted-azole derivatives