408322-07-6 = 874-05-5 反应条件:1.1 Reagents: Hydrochloric Acid Solvents: Water 标题:Synthesis And Oxidation Of 1,3-Diamino- And 1-Amino-3-Azidoindazoles 作者:Dyablo,O. V.; Pozharskii,A. F.; Kuz'Menko,V. V.; Kolesnichenko,M. A. 参考文献:Chemistry Of Heterocyclic Compounds (New York 日期:2001 卷标:37(5) 页码:567-573]
394-47-8 = 874-05-5 反应条件:1.1 Reagents: Hydrazine Hydrate (1:1) Solvents: 1-Butanol; Rt -> Reflux; 18 H,Reflux 标题:Synthesis And Structure-Activity Relationships Of Indazole Arylsulfonamides As Allosteric Cc-Chemokine Receptor 4 (Ccr4) Antagonists 作者:Procopiou,Panayiotis A.; Barrett,John W.; Barton,Nicholas P.; Begg,Malcolm; Clapham,David; Et Al 参考文献:Journal Of Medicinal Chemistry 日期:2013 卷标:56(5) 页码:1946-1960]
1219024-53-9 = 874-05-5 反应条件:1.1 Reagents: P-Toluenesulfonic Acid Solvents: Methanol; Overnight,Reflux 标题:Two-Step Synthesis Of Substituted 3-Aminoindazoles From 2-Bromobenzonitriles 作者:Lefebvre,Valerie; Cailly,Thomas; Fabis,Frederic; Rault,Sylvain 参考文献:Journal Of Organic Chemistry 日期:2010 卷标:75(8) 页码:2730-2732]
394-47-8 = 874-05-5 反应条件:1.1 Reagents: Hydrazine Hydrate (1:1) Solvents: 1-Butanol; 7 H,Reflux 标题:3-[(Imidazolidin-2-Yl)Imino]Indazole Ligands With Selectivity For The α2-Adrenoceptor Compared To The Imidazoline I1 Receptor 作者:Saczewski,Franciszek; Kornicka,Anita; Hudson,Alan L.; Laird,Shayna; Scheinin,Mika; Et Al 参考文献:Bioorganic & Medicinal Chemistry 日期:2011 卷标:19(1) 页码:321-329
2-Azidophenylamidine Hydrochloride 以 邻二氯苯 作为反应溶剂,化学反应 0.5H,以0.03 G的收率获得产物3-氨基吲唑 参考文献:Ardakani,Manouchehr Azadi; Smalley,Robert K.; Smith,Richard H.,Journal Of The Chemical Society. Perkin Transactions I,1983,# 10,P. 2501-2506 标题:Ardakani,Manouchehr Azadi; Smalley,Robert K.; Smith,Richard H.,Journal Of The Chemical Society. Perkin Transactions I,1983,# 10,P. 2501-2506
专利号:WO-9410327-A1 优先权日:1992-10-28 标 题 :Enzymatic synthesis of polyaniline 发明人:ZEMEL HAYA; QUINN JOHN F 权利人:ALLIED SIGNAL INC 摘要:This invention relates to a process for the enzymatic synthesis of electrically conductive substituted and unsubstituted polyanilines. Aniline monomer(s), an oxidizing agent, which comprises an enzyme and an electron acceptor, and an acidifying agent are reacted together to form polyanilines.
专利号:US-5420237-A 优先权日:1991-08-29 标 题:Enzymatic synthesis of polyaniline 发明人:ZEMEL HAYA; QUINN JOHN F 权利人:ALLIED SIGNAL INC 摘要:This invention relates to a process for the enzymatic synthesis of electrically conductive substituted and unsubstituted polyanilines. Aniline monomer(s), an oxidizing agent, which comprises an enzyme and an electron acceptor, and an acidifying agent are reacted together to form polyanilines.
专利号:US-2025289827-A1 优先权日:2022-12-02 标 题:Morphic forms of a mutant braf degrader and methods of manufacture thereof 发明人:YU ROBERT T; HE MINSHENG; SCHNADERBECK MATTHEW J; KREGER BRIDGET; POLLOCK ROY MACFARLANE; JIANG SIYI; LI MEIQI; CHEN BOLU; LU JIANNAN 权利人:C4 THERAPEUTICS INC 摘要:Advantageous isolated morphic forms of (3R)-3-[6-[2-cyano-3-[[ethyl(methyl)sulfamoyl]amino]-6-fluorophenoxy]-4-oxoquinazolin-3-yl]-8-[2-[1-[3-(2,4-dioxo-1,3-diazinan-1-yl)-5-fluoro-1-methylindazol-6-yl]-4-hydroxypiperidin-4-yl]acetyl]-1-oxa-8-azaspiro[4.5]decane (Compound 1), which is a mutant BRAF degrader, and methods to prepare Compound 1 morphic forms for therapeutic applications are provided in the invention. The invention also provides improved methods for the synthesis of Compound 1, new pharmaceutical compositions comprising Compound 1, and new uses of Compound 1.
专利号:US-7019094-B2 优先权日:2002-05-31 标 题:Intermediate products, methods for their preparation and use thereof 发明人:WESTMAN JACOB; LUNDIN RONNY 权利人:BIOTAGE AB 摘要:Novel solid supported intermediate products of the general formula n ncoupled to a solid polymeric support through one or both of the R 1 groups or through the R 4 group which are suitable for synthesis of heterocyclic compounds are disclosed. Methods for preparing such intermediate products are also disclosed and also the use of the intermediate products in simple and fast methods on solid phase for synthesis of heterocycles.
专利号:US-4257942-A 优先权日:1977-10-06 标题:New water-insoluble azo dyes 发明人:DEFEO FRANCESCO; CIPOLLI ROBERTO 权利人:ACNA 摘要:The present invention relates to the synthesis of new dyes having the following general formula: wherein: D is the residue of a diazotizable component of the carbocyclic or heterocyclic series X is an ethylene group, optionally substituted by halogen-methyl, alkyl C1-C4, aryl, aralkyl or CH2OCO(HN)nR (wherein R and n have the meanings hereinafter defined); R is alkyl C1-C8 optionally substituted by halogen, CN,COOH; aryl optionally substituted by one or more atoms of halogen, alkyl C1-C4, alkoxyl C1-C4; alkoxyl C1-C4; alkoxyl C1-C8; Aryloxy; aralkoxy; cycloalkoxy; aralkyl; naphthyl optionally substituted by halogen; alkenyl C2-C8, optionally substituted by halogen, CN, COOH; R1 and R2, either like or unlike each other, may be alkyl C1-C4 optionally substituted by halogen or CN groups; aralkyl; R3 is H; halogen, alkyl C1-C4; alkoxyl C1-C4, optionally substituted. n is 0 or 1.
专利号:JP-2010222357-A 优先权日:2002-03-11 标题 :Intermediate compounds for the synthesis of aminoindazole derivatives
参考文献:10.3797/scipharm.1102-08 摘要:Gupta M, Dureja H, Madan AK. Models for the prediction of receptor tyrosine kinase inhibitory activity of substituted 3-aminoindazole analogues. Sci Pharm. 2011 Apr;79(2):239–57.