专利号:WO-2013113319-A1 优先权日:2012-01-31 标题 :Process for the preparation of strontium ranelate, intermediate or hydrates thereof 发明人:KOFTIS THEOCHARIS V; ROHIT RAVIKANT SONI; BHARAT BECHARBHAI BODA; DIPAKKUMAR NARSIBHAI BHUT; VIMALKUMAR SUBHIRBHAI PATEL 权利人:PHARMATHEN SA; KOFTIS THEOCHARIS V; ROHIT RAVIKANT SONI; BHARAT BECHARBHAI BODA; DIPAKKUMAR NARSIBHAI BHUT; VIMALKUMAR SUBHIRBHAI PATEL 摘要:The present invention relates to an improved process for the synthesis of strontium ranelate compound of formula I or its hydrates thereof. More particularly, the present invention relates to an economically viable and industrially feasible process for the preparation of strontium ranelate, intermediate or its hydrates thereof.
专利号:US-2008214386-A1 优先权日:2004-03-01 标题:Catalyst for Cyclic Carbonate Synthesis 发明人:TAKAHASHI TOSHIKAZU; WATAHIKI TSUTOMU; YASUDA HIROYUKI; SAKAKURA TOSHIYASU 权利人:TAKAHASHI TOSHIKAZU; WATAHIKI TSUTOMU; YASUDA HIROYUKI; SAKAKURA TOSHIYASU 摘要:Provided are a solid catalyst which gives a cyclic carbonate at a high yield and a high selectivity, which is stable and which may be readily separated after reaction; and a method of industrially advantageous, inexpensive and safe production of a cyclic carbonate by the use of the catalyst. The catalyst contains an inorganic solid substance having a surface modified with an ionic substance containing a Group 15 element; or contains an ionic substance containing a Group 15 element, and an inorganic solid substance. The modifying group for surface modification of an inorganic solid substance is an ionic substance containing a Group 15 element. The ionic substance containing a Group 15 element is at least one substance selected from organic phosphonium salts, organic ammonium salts, organic arsonium salts and organic antimonium salts.
专利号:US-4684724-A 优先权日:1981-12-25 标题:4-Cyano-2-azetidinones and production thereof 发明人:OCHIAI MICHIHIKO; KISHIMOTO SHOJI; MATSUO TAISUKE 权利人:TAKEDA CHEMICAL INDUSTRIES LTD 摘要:4-Cyano-2-azetidinone derivatives represented by the formula ##STR1## wherein R 1 is an amino group which may be acylated or protected, X is a hydrogen atom or a methoxy group and W is a hydrogen atom or a sulfo group, and methods of producing the same, for example, as represented by ##STR2## wherein R 2 is an acylated or protected amino group, Y is a halogen atom or a group having the formula --OCOR 3 , --SCOR 3 or --S(O) n --R 3 (R 3 being a hydrocarbyl group and n an integer 1 or 2), R 4 is an amino group which may be acylated or protected and X is as defined above. Compounds [I] are useful as advantageous intermediates for the synthesis of optically active 4-substituted-2-azetidinone derivatives, and, when W=SO 3 H, [I] are also useful as antimicrobial agents and as beta-lactamase inhibitors.
专利号:US-5585510-A 优先权日:1994-06-24 标 题:Ligated polyoxometalates and methods for their synthesis 发明人:MAZANY ANTHONY M 权利人:GOODRICH CO B F 摘要:Polyoxometalates are provided which are highly soluble in organic solvents, including monomer mixtures utilized in reaction injection molding. High solubility is obtained by organic moieties incorporated in the cation and anion of compounds having the formula [R1mER2m']nMxOyLz. These compounds provide improved solubility while maintaining catalyst activity within reaction injection molding formulations. A method is also provided for preparing these polyoxometalates within an aqueous acidic medium, wherein ligands are incorporated in the complex simultaneously with the formation of the polyoxometalate complex.
专利号:US-6160181-A 优先权日:1998-09-01 标题 :Tetraene derivative and process for producing the same 发明人:SEKO SHINZO; KONYA NAOTO; TAKAHASHI TOSHIYA; FURUTANI ATSUSHI 权利人:SUMITOMO CHEMICAL CO 摘要:A tetraene derivative of the formula (1): ##STR1## wherein Ar represents an aryl group which may be optionally substituted with at least one substituent, and R 1 and R 2 are identical or different and represent a hydrogen atom, a lower alkyl group or a protective group of a hydroxyl group; synthesis methods therefor and synthesis methods using the same.
专利号:US-8017587-B2 优先权日:2001-12-28 标题:2-O- (β-D-glucopyranosyl) ascorbic acid, process for its production, and foods and cosmetics containing compositions comprising it 发明人:MAEDA MITSURU; NAKAO MASAHIRO; FUKAMI HARUKAZU 权利人:SUNTORY HOLDINGS LTD 摘要:The present invention provides a novel ascorbic acid derivative as a provitamin C with improved stability in the body and prolonged life in the body compared to conventionally known 2-O-(α-D-glucopyranosyl)ascorbic acid. n The composition comprising the novel compound 2-O-(β-D-glucopyranosyl)ascorbic acid has been extracted from plants such as from Ningxia Lycium barbarum L. and/or Lycium chinense Mill. The compositions comprising 2-O-(β-D-glucopyranosyl)ascorbic acid may be enzymatically synthesized using β-D-glucosyltransferase. Pure 2-O-(β-D-glucopyranosyl)ascorbic acid may be produced from such compositions. Alternatively, 2-O-(β-D-glucopyranosyl)ascorbic acid may be produced by chemical synthesis. The 2-O-(β-D-glucopyranosyl)ascorbic acid results in higher stability and a prolonged life of vitamin C when ingested in the body compared to the corresponding α-D-glucopyranosyl derivative, and is therefore highly suitable as a provitamin C to be used in cosmetics and foods.
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合成参考文献
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