CAS: 623-65-4; Palmitic Anhydride

相似化合物

645-66-9 626-29-9 623-66-5

上下游产品

sodium palmitate acetic anhydride 1-hexadecylcarboxylic acid n-hexadecanoyl chloridetrans-stilbene4.4'-dipalmitoyloxy-α.α'-diethyl-trans-stilbene S-palmitoyl-coenzyme A 1,2-Dipalmitoylphosphatidic acid -N-methyl-N-benzylpropanolamin3-O-1-O-Palmitoylglycero-3-O-(O-benzyl)phosphoryl-N-methyl-N-benzylpropanolamin

📜棕榈酰氯置于四丁基氯化铵 Sodium Hydroxide体系中,用 甲苯 作为反应溶剂,化学反应 3.0H,以90%的收率获得产物棕榈酸酐
参考文献:利用相转移反应的羧酸和碳酸酐的新合成
标题:利用相转移反应的羧酸和碳酸酐的新合成
摘要:使用液-液相转移条件,酰氯和烷基氯甲酸酯与一摩尔当量的氢氧化钠平稳反应,得到高产率的相应的对称羧酸和碳半酯酸酐.用这种方法很容易制得不稳定的酸酐,如4-硝基苯甲酸酐,2-糠醛和甲基丙烯酸酐,否则很难获得.该反应机理似乎不涉及将一半的酰氯中间水解为相应的羧酸钠.
DOI:10.1016/s0040-4020(01)81698-7

专利信息

专利号:US-2009099061-A1
优先权日:2006-01-27
标 题:Synthesis of carotenoid analogs or derivatives with improved antioxidant characteristics
发明人：FOSS BENTE J; NADOLSKI GEOFFRY T; LOCKWOOD SAMUEL F
权利人:FOSS BENTE J; NADOLSKI GEOFFRY T; LOCKWOOD SAMUEL F
摘要:A method is described for synthesizing and administering carotenoid compounds with improved antioxidant characteristics. In some embodiments, extension or improvement of conjugation may be employed in structural modification of carotenoids. In other embodiments, reduction of ring/chain steric hindrance may improve the lambda max, and hence, the overall antioxidant capability, of particular compounds. In other embodiments, introduction and/or increase in synthetic handles for conjugation may improve the stoichiometric ratios of conjugating moieties to the polyene backbone. The methods may be used to improve natural and/or synthetic compounds for medicinal application in the treatment of disease.

专利号:US-5137660-A
优先权日:1991-03-15
标题:Regioselective synthesis of 1,3-disubstituted glycerides
发明人：MAZUR ADAM W; HILER II GEORGE D
权利人:PROCTER & GAMBLE
摘要:A process for the selective esterification of glycerol and 1-glyceryl derivatives to 1,3-disubstituted glycerides is disclosed. This process uses a water immiscible solvent, either a hydrocarbon or halogenated hydrocarbon, a 1,3-lipase and fatty acid anhydrides. This reaction mixture selectively esterifies the primary alcohol groups of glycerol or glycerol derivatives. The preferred derivatives of glycerol are alkyl ethers, alkyl phosphates, phospholipids, alkyl and diaklyl phosphates, and sugar glycosides.

专利号:US-3998888-A
优先权日:1975-11-12
标 题:Synthesis of sulfonyl peroxides
发明人：MANNER JAMES A
权利人:PPG INDUSTRIES INC
摘要:Sulfonyl peroxides represented by the formula ##STR1## wherein R and R' independently are alkyl, cycloalkyl, or substituted alkyl or cycloalkyl groups having 1 to 20 carbons, are prepared in a liquid reaction phase by the sulfoxidation of an alkane or cycloalkane reactant with SO 2 and O 2 and acylation of the sulfoxidation product with a carboxylic acid anhydride. In the practice of this invention, an inert, immiscible organic solvent for the sulfonyl peroxide is introduced into the liquid reaction phase to dissolve the peroxide as it is formed and to produce a lower crude product phase containing the sulfonyl peroxide already dissolved in the inert solvent.

专利号:US-6544952-B1
优先权日:1994-03-15
标 题:Synthesis of glycoconjugates of the globo-H epitope and uses thereof
发明人：DANISHEFSKY SAMUEL J; LIVINGSTON PHILIP O; RAGUPATHI GOVINDASWAMI; KIM IN JONG; SCHER HOWARD; SLOVIN SUSAN
权利人:SLOAN KETTERING INST CANCER
摘要:The present invention provides a method of synthesizing a compound having the structure:as well as other related glycoconjugates useful as vaccines for inducing antibodies to epithelial cancer cells in an adjuvant therapy therefore, and in a method for preventing recurrence of epithelial cancer. The present invention also provides a vaccine comprising an amount of the compound described above effective to prevent the recurrence of cancer in a subject.

专利号:US-8940749-B2
优先权日:2011-05-31
标题:Preparation of 3-[2-[4-((6-fluoro-1, 2-benzisoxazol-3-yl)-l-piperidinyl)-6, 7, 8, 9-tetrahydor-9-hydroxy-2-methyl-4H-pyrido[ 1, 2-A]-pyrimidin-4-one(paliperidone) and paliperidone palmitate
发明人：DAVULURI RAMAMOHAN RAO; PONNAIAH RAVI; NEELA PRAVEEN KUMAR; BATTHINI GURUSWAMY; VENKATA NARASIMHARAO TELAGAREDDY; RAVANABABU KOSIREDDY; SUDHEER KALLEPALLY
权利人:DAVULURI RAMAMOHAN RAO; PONNAIAH RAVI; NEELA PRAVEEN KUMAR; BATTHINI GURUSWAMY; VENKATA NARASIMHARAO TELAGAREDDY; RAVANABABU KOSIREDDY; SUDHEER KALLEPALLY
摘要:An improved process for the synthesis of 3-[2-[4-((6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]-pyrimidin-4-one (Paliperidone) and Paliperidone Palmitate through a novel intermediate (2-Chloroethyl)-6,7,8,9-tetrahydro-2-methyl-9-hydroxy-4H-pyrido [1,2-a]pyrimidine-4-one Palmitate ester.

专利号:US-8884001-B2
优先权日:2008-05-08
标题:Preparation of intermediates useful in the synthesis of 2′-cyano-2′-deoxy-N4-palmi-toyl-1-β-D-arabinofuranosylcytosine
发明人：WOOD GAVIN; WESTWOOD ROBERT; Murofushi tsuyoshi; NUMAGAMI EIJI; TAKITA TAKASHI
权利人:WOOD GAVIN; WESTWOOD ROBERT; Murofushi tsuyoshi; NUMAGAMI EIJI; TAKITA TAKASHI; CYCLACEL LTD
摘要:The present invention relates to a process for preparing a compound of formula 682-4, said process comprising the steps of: (i) converting a compound of formula 682-1 into a compound of formula 682-2; (ii) converting said compound of formula 682-2′ into a compound of formula 682-3; and (iii) converting said compound of formula 682-3 into a compound of formula 682-4. Further aspects of the invention relate to the use of the above process in the preparation of 2′-cyano-2′-deoxy-N 4 -palmitoyl-1-β-D-arabmofuranosylcytosine, a pyrimidine nucleoside which is therapeutically useful in the treatment and/or prevention of cancer.