CAS: 598-58-3; Methyl Nitrate

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📜Trimethoxonium Tetrafluoroborate置于nitrate体系中,用 水 作为反应溶剂,化学反应 0.08H,反应生成 硝酸甲酯
参考文献:三氟四硼酸三烷基氧鎓烷基化水相后,无机阴离子物种的蒸气反应生成
标题:三氟四硼酸三烷基氧鎓烷基化水相后,无机阴离子物种的蒸气反应生成
摘要:三烷基氧鎓四氟硼酸盐的水相反应,R 3 ö + Bf 4-(r═me,等)已在简单无机阴离子基底,例如卤素离子,氰化物,硫氰酸盐,硫化物和几个含氧阴离子或它们相应的含氧酸的烷基化进行了测试.分离出气态产物并通过气相色谱质谱法(gc-Ms)鉴定.分别获得了碘化物,溴化物和氯化物的烷基化衍生物ri,Rbr和rcl,而对于氟化物,其向rf的转化效率非常低.rcn和r 2获得了氰化物和硫化物的s,而硫氰酸盐得到的主要反应产物为rscn,其中含有少量烷基异硫氰酸盐rncs(<7%).在测试的含氧阴离子中,仅亚硝酸盐和硝酸盐分别以r-O-No和r-O-No 2的形式给出挥发性衍生物.反应通过添加et进行3 ö + Bf 4-的ch 2氯2中的反应产物的有机相至含水样品与萃取,未能确定其它不易挥发的反应产物.在4Ml反应瓶中(使用2毫升样品ť = 25oc),100μl的2M的et 3 ö + Bf
DOI:10.1021/ac900865D

专利信息

专利号:US-10793495-B2
优先权日:2015-08-14
标 题:Synthesis of polyaryl substituted aryl compounds
发明人：BOULOS RAMIZ; FEUTRILL JOHN
权利人:BOULOS & COOPER PHARMACEUTICALS PTY LTD
摘要:A method for the synthesis of a aryl compound of Formula (1).n nU T-W—R 1 ) n    (1)

专利号:US-3983145-A
优先权日:1973-11-01
标 题:Use of alpha-di(lower alkoxy) anthraquinones in the synthesis of Alizarin Saphirols
发明人：WHITE DAVID L; FITZPATRICK JOSEPH W
权利人:TOMS RIVER CHEMICAL CORP
摘要:Alpha-dihydroxyanthraquinones used as intermediates in the synthesis of many dyestuffs, such as the Alizarin Saphirols (e.g. Color Constitution No. 63000, 63005, 63010, 63011, 63315 and 63610) can be replaced on an equimolar basis by alpha-di(lower alkoxy)anthraquinones. The alpha-di(lower alkoxy) anthraquinones can be converted in a single step, by treatment with oleum, to the corresponding alpha-dihydroxyanthraquinone-beta-disulfonic acids in almost quantitative yield. The corresponding diamine is obtained by dinitrating followed by reduction of the nitro groups. The known intermediate, leuco 1,4,5,8-tetrahydroxyanthraquinone (see C.I. No. 62500) can be obtained either by reduction of the diamine or by reduction of the dinitro compound. In one embodiment, the alpha-di(lower alkoxy)anthraquinone is obtained from dinitroanthraquinone by treatment thereof with methanol and KOH.

专利号:US-9597327-B2
优先权日:2005-05-25
标 题:Synthesis of (R)-N-methylnaltrexone
发明人：DOSHAN HAROLD D; PEREZ JULIO
权利人:PROGENICS PHARM INC
摘要:This invention relates to stereoselective synthesis of R-MNTX and intermediates thereof, pharmaceutical preparations comprising R-MNTX or intermediates thereof and methods for their use.

专利号:US-7211590-B2
优先权日:2002-08-01
标 题:Nitrosated proton pump inhibitors, compositions and methods of use
发明人：FANG XINQIN; GARVEY DAVID S; LETTS L GORDON
权利人:NITROMED INC
摘要:The invention describes novel nitrosated proton pump inhibitor compounds and pharmaceutically acceptable salts thereof, and novel compositions comprising at least one nitrosated proton pump inhibitor compound, and, optionally, at least one compound that donates, transfers or releases nitric oxide, stimulates endogenous synthesis of nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor or is a substrate for nitric oxide synthase, and/or at least one therapeutic agent. The invention also provides novel compositions comprising at least one nitrosated proton pump inhibitor compound, and at least one compound that donates, transfers or releases nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor, stimulates endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase and/or at least one therapeutic agent. The invention also provides novel kits comprising at least one nitrosated proton pump inhibitor compound, and, optionally, at least one nitric oxide donor and/or at least one therapeutic agent. The invention also provides methods for treating gastrointestinal disorders; facilitating ulcer healing; decreasing the recurrence of ulcers; improving gastroprotective properties, anti-Helicobacter pylori properties or antacid properties of proton pump inhibitors; decreasing or reducing the gastrointestinal toxicity associated with the use of nonsteroidal antiinflammatory compounds; treating bacterial infections and/or viral infections.

专利号:US-9409879-B2
优先权日:2011-03-29
标 题 :Total synthesis of redox-active 1.4-naphthoquinones and their metabolites and their therapeutic use as antimalarial and schistomicidal agents
发明人：DAVIOUD-CHARVET ELISABETH; LANFRANCHI DON ANTOINE; JOHANN LAURE; WILLIAMS DAVID LEE; CESAR RODO ELENA
权利人:DAVIOUD-CHARVET ELISABETH; LANFRANCHI DON ANTOINE; JOHANN LAURE; WILLIAMS DAVID LEE; CESAR RODO ELENA; CENTRE NAT RECH SCIENT
摘要:Naphthoquinones, azanaphthoquinones and benxanthones, their process of synthesis and methods of their use as antimalarial or antischistosomal agents.

专利号:US-9359327-B2
优先权日:2008-06-30
标题:Process for the preparation of substituted pyrimidine derivatives
发明人：CESCO-CANCIAN SERGIO; CHEN HONGFENG; GRIMM JEFFREY S; MANI NEELAKANDHA S; MAPES CHRISTOPHER M; PALMER DAVID C; PIPPEL DANIEL J; SORGI KIRK L; XIAO TONG
权利人:JANSSEN PHARMACEUTICA NV
摘要:The present invention is directed to processes for the preparation of substituted pyrimidine derivatives, useful as intermediates in the synthesis of histamine H 4 receptor modulators, and to intermediates in H4 modulator synthesis.