CAS: 587-63-3; (S)-4-Methoxy-6-Phenethyl-5,6-Dihydro-2H-Pyran-2-One
该化合物是卡瓦工厂(Piper methysticum)中发现的自然产生的卡瓦内酮,是造成该工厂药理效应的主要生物活性化合物之一.化学上被归类为发泡激素衍生物,二hlekavain表现出温和的厌氧和肌肉放松特性.其分子结构具有饱和的α-极性环,有助于其稳定性和生物利用率.研究表明它与伽马--巴受体发生相互作用,尽管与卡瓦因等其他卡瓦内激素相比,其威力较低.Dhylkavain经常被研究其在无重大镇静作用的...
- 英文名称(S)-4-Methoxy-6-Phenethyl-5,6-Dihydro-2H-Pyran-2-One
- 中文名称二氢醉椒素
- IUPAC名称(S)-4-methoxy-6-phenethyl-5,6-dihydro-2H-pyran-2-one
- 其它别名2H-Pyran-2-one,5,6-dihydro-4-methoxy-6-(2-phenylethyl)-, (S)-; 2H-Pyran-2-one,5,6-dihydro-4-methoxy-6-phenethyl- (8CI); (+)-7,8-Dihydrokavain; (+)-Dihydrokavain; (+)-Dihydrokawain; (S)-(+)-Dihydrokawain; 7,8-Dihydrokavain; 7,8-Dihydrokawain; Dihydrokavain; Dihydrokawain; Kawain, dihydro-; Marindinin
- CAS编号587-63-3
- MFCD编号:MFCD01694032
- EINECS号:106-462-0
- FDA UNII编号:NW8ZGW9XRZ
- 分子式:C14H16O3分子量:232.28
- 产品CID: 1562698
- 产品分类分析化学 → 标准品 → 分析标准品
物理性质
- 熔点56-60 °C
- 沸点413.6±45.0 °C at 760 mmHg
- 闪点175.6±23.3 °C
- 密度1.1±0.1 g/cm3
- PSA:35.53
- LogP:1.95
- 折射率1.544
- 蒸汽压0.0±1.0 mmHg at 25°C
- 溶解性DMF:25.0(Max Conc. mg/mL);107.62(Max Conc. mM)DMSO:25.0(Max Conc. mg/mL);107.62(Max Conc. mM)Ethanol:5.0(Max Conc. mg/mL);21.52(Max Conc. mM)
- 外观形态白色粉末
- 储存条件-20°C
- 产品应用该化合物用作内容确定,识别和药理实验.
MSDS等安全信息
欧盟法规
C&L通报上下游产品
CAS号77-78-1 硫酸二甲酯 | CAS号182950-96-5 (6S)-6-(2-pheny... | CAS号30414-58-5 Methyl 3-oxo-5-... | CAS号1449-46-3 苄基三苯基溴化膦 | CAS号152203-65-1 (4S)-2,2-dimeth... | CAS号100-39-0 溴化苄 | CAS号35217-21-1 methyl 3-methox... | CAS号862464-32-2 methyl (5S)-5-h...合成工艺路线路线简述
📜Kawain置于甲醇,钯体系中,化学反应生成 二氢醉椒素
参考文献:Borsche; Peitzsch,Chemische Berichte,1930,Vol. 63,P. 2414,2416
标题:Borsche; Peitzsch,Chemische Berichte,1930,Vol. 63,P. 2414,2416
海关参考信息
- 2901210000-乙烯
2901220000-丙烯
2902600000-乙苯
2905122000-异丙醇 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-6677462-B2
优先权日:2001-08-06
标题:Asymmetric synthesis of kavalactones
发明人：CHEN SHOUJUN; SUN LIJUN; MCCLEARY JOEL
权利人:KAVA PHARMACEUTICALS INC
摘要:This invention relates to preparation of enantio-enriched compounds, and more particularly to enantio-enriched kavalactone compounds and derivatives thereof. The methods provide compounds that are useful as reagents, or building blocks, in the construction of other enantio-enriched compounds.
专利号:US-2019271015-A1
优先权日:2018-01-17
标题 :Enzymatic synthesis of kavalactones and flavokavains
专利号:US-10941429-B2
优先权日:2018-01-17
标 题:Enzymatic synthesis of kavalactones and flavokavains
专利号:CA-2456720-A1
优先权日:2001-08-06
标题 :Asymmetric synthesis of kavalactones
专利号:EP-1414463-A4
优先权日:2001-08-06
标题 :ASYMMETRIC SYNTHESIS OF KAVALACTONES
专利号:JP-2005507867-A
优先权日:2001-08-06
标 题 :Asymmetric synthesis of kava lactone
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
1: Herath W, Ferreira D, Mikell JR, Khan IA. Microbial metabolism. Part 5. Dihydrokawain. Chem Pharm Bull (Tokyo). 2004 Nov;52(11):1372-4. Erratum in: Chemistry. 2005 Mar 18;11(7):1975. doi: 10.1093/toxsci/kfr235. Epub 2011 Sep 9.
6: Otoguro K, Iwatsuki M, Ishiyama A, Namatame M, Nishihara-Tsukashima A, Kiyohara H, Hashimoto T, Asakawa Y, Omura S, Yamada H. In vitro antitrypanosomal activity of some phenolic compounds from propolis and lactones from Fijian Kawa (Piper methysticum). J Nat Med. 2012 Jul;66(3):558-61. doi: 10.1007/s11418-011-0613-z. Epub 2011 Nov 25. doi: 10.1002/anie.200806080. German. German. Epub 2004 Jul 28.
合成参考文献
参考文献:10.1078/0944711041495263
摘要:Zou L, Henderson GL, Harkey MR, Sakai Y, Li A. Effects of kava (Kava-kava, 'Awa, Yaqona, Piper methysticum) on c-DNA-expressed cytochrome P450 enzymes and human cryopreserved hepatocytes. Phytomedicine. 2004;11(4):285–94. doi: 10.1078/0944711041495263.
参考文献:10.1371/journal.pone.0019825
摘要:Iwai Y, Murakami K, Gomi Y, Hashimoto T, Asakawa Y, Okuno Y, Ishikawa T, Hatakeyama D, Echigo N, Kuzuhara T. Anti-Influenza Activity of Marchantins, Macrocyclic Bisbibenzyls Contained in Liverworts. PLoS ONE. 2011 May 20;6(5):e19825. doi: 10.1371/journal.pone.0019825.
参考文献:10.1016/j.cbi.2022.109883
摘要:Melchert PW, Qian Y, Zhang Q, Klee BO, Xing C, Markowitz JS. In vitro inhibition of carboxylesterase 1 by Kava (Piper methysticum) Kavalactones. Chemico-Biological Interactions. 2022 Apr;357():109883. doi: 10.1016/j.cbi.2022.109883.
参考文献:10.1016/s0021-9673(01)00979-7
摘要:Kubátová A, Miller DJ, Hawthorne SB. Comparison of subcritical water and organic solvents for extracting kava lactones from kava root. J Chromatogr A. 2001 Jul 20;923(1-2):187–94. doi: 10.1016/s0021-9673(01)00979-7.
摘要:Archives Internationales de Pharmacodynamie et de Therapie., 177(261), 1969 []
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