CAS: 53312-81-5; 5-Amino-2-Fluorobenzonitrile

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CAS号17417-09-3 2-氟-5-硝基苯腈 | CAS号16588-02-6 2-氯-5-硝基苯甲腈 | CAS号161886-21-1 2-FLUORO-5-HYDR... | CAS号771571-82-5 5-氨基-2-氟苄胺

2,5-二氯苯甲腈置于氨体系中,用 环丁砜 作为反应溶剂,化学反应 8.0H,反应生成 5-氨基-2-氟苯腈
参考文献:一种合成2-氟-5-溴对苯二甲酸的方法
标题:一种合成2-氟-5-溴对苯二甲酸的方法
摘要:本发明公开了一种合成2-氟-5-溴对苯二甲酸的方法,其合成步骤为:先把2,5-二氯苯腈和干燥的氟化钾用环丁砜溶解,加热反应,得到2,5-二氟苯腈(纯度为99%);再一次加入新的环丁砜溶液,通入氯气2小时,得到2-氟-5-氨基苯腈;在经过重氮化处理加入丙烯腈,氢溴酸,加热反应.用稀释用乙酸乙酯进行萃取2-氟-5溴对苯二腈.最后将2-氟-5溴对苯二腈在稀硫酸的水溶液中水解8小时,再一次用乙酸乙酯进行萃取得到15.44G2-氟-5-溴对苯二甲酸,产率为83.99%以上.

专利信息

专利号:US-12049470-B2
优先权日:2021-02-01
标 题 :MK2 inhibitors, the synthesis thereof, and intermediates thereto
发明人：RUCHELMAN ALEXANDER L; COOMBS JOHN R; ZHU KEMING; LIM DANIEL; JOE CANDICE LEE; GEORGE DAVID T; ZHENG BIN; LIN DONG
权利人:CELGENE CORP
摘要:The present disclosure provides novel synthetic intermediates useful in the synthesis of MK2 kinase inhibitors.

专利号:US-2006069270-A1
优先权日:2004-09-27
标 题 :Process for the preparation of 1,3,5-trisubstituted pyrazoles via [3+2] cycloaddition
发明人：SHAPIRO RAFAEL; ROSSANO LUCIUS T; TENHUISEN KAREN L
权利人:SHAPIRO RAFAEL; ROSSANO LUCIUS T; TENHUISEN KAREN L
摘要:A process for the preparation of 1,3,5-trisubstituted pyrazole compounds, which are useful intermediates in the synthesis of factor Xa inhibitors.

专利号:WO-2021257669-A1
优先权日:2020-06-17
标题 :Synthesis of substituted arylmethylureas, analogues, and crystalline forms thereof and methods of using same
发明人：PALLERLA MAHESH KUMAR; PAMULAPATI GANAPATI REDDY; SPINK JAN MICHELLE
权利人:ARBUTUS BIOPHARMA CORP; ARBUTUS BIOPHARMA INC
摘要:The present disclosure includes synthetic methods for preparing certain substituted (hetero)arylmethyl urea compounds, compositions comprising the same, and crystalline forms thereof, which can be used to treat, ameliorate, and/or prevent hepatitis B virus (HBV) infections in a patient.

专利号:US-10822377-B2
优先权日:2015-03-04
标 题:Substituted urea depsipeptide analogs as activators of the ClpP endopeptidase
发明人：LEE RICHARD E; ZHAO YING; JIUYU LIU
权利人:ST JUDE CHILDRENS RES HOSPITAL
摘要:In one aspect, the invention relates to substituted urea depsipeptide analogs, derivatives thereof, and related compounds, which are useful as activators the ClpP endopeptidease; synthesis methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating infectious disease using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.