CAS: 452092-31-8; Ethyl 1-Cyclopropyl-6,7-Difluoro-8-Hydroxy-4-Oxo-1,4-Dihydroquinoline-3-Carboxylate

英文名称Ethyl 1-Cyclopropyl-6,7-Difluoro-8-Hydroxy-4-Oxo-1,4-Dihydroquinoline-3-Carboxylate
中文名称1-环丙基-6,7-二氟-8-羟基-4-氧代-1,4-二氢喹啉-3-甲酸乙酯
IUPAC名称ethyl 1-cyclopropyl-6,7-difluoro-8-hydroxy-4-oxo-1,4-dihydroquinoline-3-carboxylate
其它别名Ethyl 1-Cyclopropyl-6,7-Difluoro-8-Hydroxy-4-Oxo-1,4-Dihydroquinoline-3-Carboxylate; Moxifloxacin Impurity R; Moxifloxacin Impruty 26; 1-Cyclopropyl-6,7-Difluoro-1,4-Dihydro-8-Hydroxy-4-Oxo-3-Quinolinecarboxylic Acid Ethyl; Moxifloxacin Impurity N; Moxifloxacin Impurity 25/moxifloxacin Difluoro Hydroxy Ethyl Ester/1-Cyclopropyl-6,7-Difluoro-1,4-Dihydro-8-Hydroxy-4-Oxo-3-Quinolinecarboxylic Acid Ethyl Ester; Moxifloxacin-15; Moxifloxacin Difluoro Hydroxy Ethyl Ester
CAS编号452092-31-8
MFCD编号:MFCD26387581
FDA UNII编号:JCB2HCF8L9
分子式:C15H13F2NO4
分子量:309.27
产品CID: 1456748
产品分类分析化学 → 标准品 → 药典标准品和杂质标准品

相似结构搜索
InChIKey: RUIZYAGCNHBFJT-UHFFFAOYSA-N
InChI=1S/C15H13F2NO4/c1-2-22-15(21)9-6-18(7-3-4-7)12-8(13(9)19)5-10(16)11(17)14(12)20/h5-7,20H,2-4H2,1H3…
计算化学: 氢键受体数7.0氢键供体数1.0可旋转键数4.0

MSDS等安全信息

GHS符号GHS07
警示词Warning
危险描述H302-H315-H319-H335
防范说明P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501
安全声明H303+H313+H333

上下游产品

1-cyclopropyl-6,7-difluoro-8-hydroxy-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid ethanol 8-benzyloxy-1-cyclopropyl-6,7-difluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate ethyl 1-cyclopropyl-6,7-difluoro-8-difluoromethoxyl-1,4-dihydro-4-oxo quinoline-3-carboxylate 8-((S)-1-benzyl-4-methylene-piperidin-2-ylmethoxy)-1-cyclopropyl-6,7-difluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester ethyl 8-(2-((2S,4R)-1-(benzyloxycarbonyl)-4-(tert-butyldimethylsilyloxy)pyrrolidin-2-yl)ethoxy)-1-cyclopropyl-6,7-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate ethyl 7-((2S,4R)-4-benzyloxycarbonylamino-2-(hydroxymethyl)pyrrolidin-1-yl)-1-cyclopropyl-6-fluoro-8-fomyl-4-oxo-1,4-dihydroquinoline-3-carboxylate

合成工艺路线路线简述

Ethyl 8-(Benzyloxy)-1-Cyclopropyl-6,7-Difluoro-1,4-Dihydro-4-Oxoquinoline-3-Carboxylate置于palladium(II) Hydroxide 氢气体系中,用四氢呋喃,乙醇作为反应溶剂,化学反应 2.0H,反应生成 1-环丙基-6,7-二氟-1,4-二氢-8-羟基-4-氧代-3-喹啉羧酸乙酯
参考文献:Novel Antibacterial Compounds
标题:Novel Antibacterial Compounds
摘要:该发明涉及一种新型嵌合抗生素,其化学式为i,其中r1为ch2Nhcor5,杂环烷基甲基,杂环氧甲基或杂环氨基甲基;r2为h,Oh,Oso3H,Opo3H2,och2Opo3H2,ococh2Ch2Cooh,ocor6;r3为h或卤素;r4为(c1-C3)烷基,(c1-C3)卤代烷基或环烷基;r5为烷基或卤代烷基;r6为天然氨基酸残基或二甲氨基甘氨酸残基.这些嵌合化合物在制造治疗感染(例如细菌感染)的药物中非常有用.