CAS: 4439-02-5; 3,4-(Methylenedioxy)Phenylacetonitrile

上下游产品

5-(chloromethyl)-1,3-benzodioxole sodium cyanide potassium cyanide benzo[1,3]dioxol-5-yl-acetaldehyde-oxime 2-(benzo[d][1,3]dioxol-5-yl)-1-(2,4,6-trihydroxyphenyl)ethanone 2,4-dihydroxy-6-methoxy-3',4'-methylenedioxy-deoxybenzoin c-phenyl-acrylonitrile2-benzo[1,3]dioxol-5-yl-3c-phenyl-acrylonitrile c-(4-dimethylamino-phenyl)-acrylonitrile2-benzo[1,3]dioxol-5-yl-3c-(4-dimethylamino-phenyl)-acrylonitrile

胡椒基氯置于氰化钠体系中,用78%的收率获得产物1,3-苯并二氧杂环戊烯-5-乙腈
参考文献:Syntheses Based On-Phenylethylamines. I. Preparation Of Substituted-Phenylethylamines
标题:Syntheses Based On-Phenylethylamines. I. Preparation Of Substituted-Phenylethylamines
摘要:
DOI:10.1007/bf00605201

专利信息

专利号:US-7816375-B2
优先权日:2000-09-11
标 题 :Ligands for monoamine receptors and transporters, and methods of use thereof
发明人：AQUILA BRIAN M; BANNISTER THOMAS D; CUNY GREGORY D; HAUSKE JAMES R; HOLLAND JOANNE M; PERSONS PAUL E; RADEKE HEIKE; WANG FENGJIANG; SHAO LIMING
权利人:SEPRACOR INC
摘要:One aspect of the present invention relates to heterocyclic compounds. A second aspect of the present invention relates to the use of the heterocyclic compounds as ligands for various mammalian cellular receptors, including dopamine, serotonin, or norepinephrine transporters. The compounds of the present invention will find use in the treatment of numerous ailments, conditions and diseases which afflict mammals, including but not limited to addiction, anxiety, depression, sexual dysfunction, hypertension, migraine, Alzheimer's disease, obesity, emesis, psychosis, schizophrenia, Parkinson's disease, inflammatory pain, neuropathic pain, Lesche-Nyhane disease, Wilson's disease, and Tourette's syndrome. An additional aspect of the present invention relates to the synthesis of combinatorial libraries of the heterocyclic compounds, and the screening of those libraries for biological activity, e.g., in assays based on dopamine transporters.

专利号:US-2015038591-A1
优先权日:2002-05-31
标 题:Compounds, compositions and methods for the treatment of tauopathies
发明人：SNOW ALAN D; CAM JUDY A; CASTILLO GERARDO; HU QUBAI; LAKE THOMAS
权利人:PROTEOTECH INC
摘要:Bis- and tris-dihydroxyaryl compounds and their methylenedioxy analogs and pharmaceutically acceptable esters, their synthesis, pharmaceutical compositions containing them, and their use in the treatment of tauopathies, such as Alzheimer's disease and Parkinson's disease, and the manufacture of medicaments for such treatment.

专利号:US-7919530-B2
优先权日:2002-05-31
标 题 :Compounds, compositions, and methods for the treatment of synucleinopathies
发明人：ESPOSITO LUKE A; CUMMINGS JOEL; HUDSON F MICHAEL; SNOW ALAN D
权利人:PROTEOTECH INC
摘要:Bis- and tris-dihydroxyaryl compounds and their methylenedioxy analogs and pharmaceutically acceptable esters, their synthesis, pharmaceutical compositions containing them, and their use in the treatment of synucleinopathies, such as Parkinson's disease, and the manufacture of medicaments for such treatment.

专利号:US-7601876-B2
优先权日:2002-05-31
标题 :Compounds, compositions and methods for the treatment of amyloid diseases such as systemic AA amyloidosis
发明人：SNOW ALAN D; NGUYEN BETH P; CASTILLO GERARDO M; SANDERS VIRGINIA J; LAKE THOMAS P; LARSEN LESLEY; WEAVERS REX T; LORIMER STEPHEN D; LARSEN DAVID S; COFFEN DAVID L; COFFEN CHARLOTTE
权利人:PROTEOTECH INC
摘要:Bis- and tris-dihydroxyaryl compounds and their methylenedioxy analogs and pharmaceutically acceptable esters, their synthesis, pharmaceutical compositions containing them, and their use in the treatment of amyloid diseases, especially Aβ amyloidosis, such as observed in Alzheimer's disease, IAPP amyloidosis, such as observed in type 2 diabetes, AA/SAA amyloidosis, such as observed in systemic AA amyloidosis and synucleinopathies, such as observed in Parkinson's disease, and the manufacture of medicaments for such treatment.

专利号:US-7777060-B2
优先权日:2007-02-14
标题:Platinum analogs with bis-nitrile-containing ligands
发明人：CHEN XINGHAI; PETLURU PAVANKUMAR N V; HUANG QIULI; NARKUNAN KESAVARAM; HAUSHEER FREDERICK
权利人:BIONUMERIK PHARMACEUTICALS INC
摘要:Disclosed herein are novel platinum-based analogs possessing two nitrile substituent groups (bis-nitrile) covalently-bonded to the platinum. Also disclosed herein are the reaction schemes for the synthesis of said platinum complexes, as well as quantitative in vitro IC50 data.

专利号:WO-2010039911-A1
优先权日:2008-10-01
标题 :Calcilytic compounds
发明人：JEONG JAE U; MARQUIS ROBERT W JR
权利人:GLAXOSMITHKLINE LLC; JEONG JAE U; MARQUIS ROBERT W JR
摘要:Novel calcilytic compounds, pharmaceutical compositions, methods of synthesis and methods of using them are provided.