专利号:WO-2008075165-A1 优先权日:2006-12-19 标 题 :Novel process for the synthesis of [r-(r*, r*)]-2-(4-fluorophenyl)-beta, delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoic acid or a pharmaceutically acceptable salt thereof 发明人:CHOPRA TIMOTHY JAY; O'NEILL PADRAIG MARY; WILKES PHILIPPA BRENDA 权利人:PFIZER PROD INC; CHOPRA TIMOTHY JAY; O'NEILL PADRAIG MARY; WILKES PHILIPPA BRENDA 摘要:An improved synthesis for the preparation of [R-(R*, R*)]-2-(4-fluorophenyl)- β, δ-dihydroxy-5-(1- methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1 H-pyrrole-1-heptanoic acid or a pharmaceutically acceptable salt thereof, as well as other valuable intermediates used in the process, are described. The compounds prepared by a process of the invention are useful in treating hyperlipidemia, hypercholesterolemia, osteoporosis, benign prostatic hyperplasia, or Alzheimer's disease.
专利号:US-7399806-B2 优先权日:2003-06-26 标 题:Synthesis of photoresist polymers 发明人:BENOIT DIDIER; SAFIR ADAM; CHANG HAN-TING; CHARMOT DOMINIQUE; OKAMOTO KENJI; NISHIMURA ISAO; WANG YONG 权利人:SYMYX TECHNOLOGIES INC 摘要:The present invention is directed to the preparation of photoresist polymers via living free radical polymerization techniques. Sterically bulky ester monomers are utilized as the polymerization components. Use of chain transfer agents is included in polymerization processing conditions. Cleavage of polymer terminal end groups that include a heteroatom are described.
专利号:US-8475998-B2 优先权日:2010-12-20 标 题 :Compound synthesis method, microarray, acid-transfer composition, and biochip composition 发明人:YUN HYOJIN; YOO CHANGEUN; KIM MYUNG-SUN; KIM SOO-KYUNG; NISHIKAWA KOUJI; GOTO HIROFUMI; MIYAMOTO HIDETOSHI 权利人:YUN HYOJIN; YOO CHANGEUN; KIM MYUNG-SUN; KIM SOO-KYUNG; NISHIKAWA KOUJI; GOTO HIROFUMI; MIYAMOTO HIDETOSHI; SAMSUNG ELECTRONICS CO LTD; JSR CORP 摘要:A compound synthesis method includes bonding a first compound to a substrate to form a first film. A second film is formed on the first film using an acid-transfer composition including (A) a polymer that includes a structural unit shown by a following formula (1) and a structural unit shown by a following formula (2), (B) a photoacid generator shown by a following formula (3), and (C) a sensitizer shown by a following formula (4). The second film is exposed to remove the protecting group from the first compound under an exposed area of the second film. An acid generated in the exposed area of the second film is transferred to the first film. The second film after being exposed is removed. A second compound is bonded to the first compound from which the protecting group has been removed.
专利号:US-7238823-B2 优先权日:2005-06-30 标 题 :Platinum complexes with mononitrile-containing ligands 发明人:XIAO ZEJUN; HAUSHEER FREDERICK H; PETLURU PAVANKUMAR 权利人:BIONUMERIK PHARMACEUTICALS INC 摘要:Disclosed herein are novel platinum-based complexes possessing one nitrile substituent group (mononitrile) covalently-bonded to the platinum, one or more nitrogen donor ligands capable of forming hydrogen bonds with the bases in DNA or RNA and leaving groups (i.e., L 1 and L 2 ) which can be hydrolyzed in vivo to active species, which can then form coordinate adducts with DNA or RNA at the Guanine or Adenine bases thereof. Also disclosed herein are the reaction schemes for the synthesis of said platinum complexes, as well as methods of treatment of various types of cancer by the administration of a pharmaceutically-effective dose of said novel platinum complexes.
专利号:US-9937151-B2 优先权日:2010-06-18 标题 :Carbapenem antibacterials with gram-negative activity 发明人:CHOI WOO-BAEG; GRUSZECKA-KOWALIK EWA; JOO HYUNG-YEUL; LIU SHUANGPEI; MAO SHULI; LI YONGFENG; KIM DEOG-IL 权利人:FOB SYNTHESIS INC 摘要:The present invention provides β-methyl carbapenem compounds and pharmaceutical compositions useful in the treatment of bacterial infections and methods for treating such infections using such compounds and/or compositions. The invention includes administering an effective amount of a carbapenem compound or salt and/or prodrug thereof to a host in need of such a treatment.
专利号:US-7250475-B2 优先权日:2003-06-26 标 题:Synthesis of photoresist polymers
摘要:Kang, F.-A.; Yang, S.-M., Science of Synthesis Knowledge Updates, (2015) 2, 216. 摘要:Bagal, D. B.; Bhanage, B. M., Science of Synthesis: Catalytic Reduction in Organic Synthesis, (2018) 2, 387.