CAS: 40967-67-7; Trimethyl Ethane-1,1,2-Tricarboxylate

相似化合物

26717-67-9 10420-33-4 922-84-9

氯乙酸甲酯,丙二酸二甲酯置于potassium Carbonate体系中,用 丙酮 作为反应溶剂,化学反应 18.0H,以41%的收率获得产物2-甲氧羰基琥珀酸二甲酯
参考文献:用于评估烷基铜试剂电子转移能力的化学标度
标题:用于评估烷基铜试剂电子转移能力的化学标度
摘要:为了评估有机铜试剂的电子转移能力,研究了合适的迈克尔受体与甲基和丁基铜试剂的反应.三甲基亚乙基-1,1,2-三羧酸酯(1A)与甲基铜试剂的反应以非常好至高产率得到共轭加合物2A和还原产物3A的混合物.2A 和 3A 的比例随铜种类而变化,并按以下顺序降低:Mecu(Cn)Li > Mecu > Me2Cu(Cn)Li2 >> Me2Culi > Me3Culi2.中间体铜物质的 13C NMR 研究和氧化实验证实,还原产物 3A 是通过电子转移过程产生的,而共轭加合物 2A 是通过 Mecuiln 的亲核攻击提供的.最后,甲基铜试剂的电子转移能力顺序为:Me3Culi2>Me2Culi>>Me2Cu(Cn)Li2>Mecu>Mecu(Cn)Li.通过使用 3-环丙基-2-甲氧基羰基-3-苯基-2-丙烯酸酯 (9) 作为迈克尔...
DOI:10.1246/bcsj.70.1953

专利信息

专利号:US-4442298-A
优先权日:1982-08-30
标 题:Chemical synthesis of ethylene/maleic anhydride dimer with phenylethyl end group
发明人：TOU JACOB S; SCHLEPPNIK ALFRED A
权利人:MONSANTO CO
摘要:A phenylethyl substituted dimer of ethylene and maleic anhydride, names 7-phenyloctane-(1,2),(5,6)-dianhydride, is chemically synthesized by n (a) alkylating alkyl 2,4-dihalobutyrate with alkyl 2-cyano-3-phenylbutyrate, n (b) alkylating the resulting halide condensation product with a carboxylate selected from the group consisting of trialkyl ethane-1,1,2-tricarboxylate and dimethyl cyanoethane-1,2-dicarboxylate, n (c) acid hydrolyzing the resulting tetra or pentaester accompanied by decarboxylating, and n (d) dehydrating the resulting tetra-acid to yield the desired phenylethyl substituted dimer of ethylene and maleic anhydride, n wherein the alkyls in the butyrate and carboxylate ester groups each contain from one to about four carbon atoms and halo is selected from the group consisting of bromo, chloro and iodo. n The dimer has anti-tumor and anti-viral properties and can be used in silver halide emulsions.

专利号:EP-1978012-A1
优先权日:2004-08-31
标 题:Alternative synthesis of renin inhibitors and intermediates thereof

专利号:EP-1789377-B1
优先权日:2004-08-31
标题:Alternative synthesis of renin inhibitors and intermediates thereof

专利号:GB-2126228-A
优先权日:1982-08-30
标题 :Chemical synthesis of ema dimer with phenylethyl end group