专利号:US-2024024489-A1 优先权日:2020-11-20 标 题:Protected disaccharides, their process of preparation and their use in the synthesis of zwitterionic oligosaccharides, and conjugates thereof 发明人:MULARD LAURENCE; DHARA DEBASHIS; PFISTER HELENE; PAOLETTI JULIE; PHALIPON ARMELLE; GUERREIRO-INVERNO CATHERINE 权利人:PASTEUR INSTITUT 摘要:The present invention provides zwitterionic oligosaccharides, in particular fragments of the surface polysaccharides from Shigella sonnei and Shigella sonnei conjugates comprising them. The present invention also provides protected disaccharides, their process of preparation and their use in the synthesis of zwitterionic oligosaccharides, and conjugates thereof, the disaccharide repeating unit of Shigella sonnei being: (I)
专利号:US-10919904-B2 优先权日:2016-08-17 标 题 :Northern-southern route to synthesis of bacteriochlorins 发明人:LIU YIZHOU; LINDSEY JONATHAN S; ALLU SRINIVASA RAO; FUJITA HIKARU 权利人:UNIV NORTH CAROLINA STATE 摘要:Described herein are chlorins, bacteriochlorins, methods and intermediates for the synthesis of bacteriochlorins, and methods of using such bacteriochlorins for, among other things, diagnostic and therapeutic purposes such as luminescent compounds in flow cytometry, and as active agents in photodynamic therapy (PDT).
专利号:US-12108759-B2 优先权日:2018-11-04 标 题:Synthesis of antimicrobial carbon dots and uses thereof 发明人:JELINEK RAZ; BHATTACHARYA SAGARIKA; OTIS GIL 权利人:B G NEGEV TECHNOLOGIES & APPLICATIONS LTD AT BEN GURION UNIV 摘要:The present invention relates to antibacterial carbon dots, having aminoguanidine functionality on their outermost surface. The invention further relates to the synthesis of said antibacterial carbon dots, and to the uses of these carbon dots for inhibiting a biofilm formation in the presence of said carbon dots and as fluorescent labeling markers for specific bacteria.
专利号:US-10882813-B2 优先权日:2014-12-17 标 题:Method for the synthesis of ferric oraganic compounds 发明人:PULLAGURLA MANIK REDDY; NANDA KUMAR MECHERIL VALSAN; RANGISETTY JAGADEESH BABU; BHUDETI RAJESH; NAGARAPU RADHA 权利人:BIOPHORE INDIA PHARMACEUTICALS PVT LTD 摘要:The present invention relates to an improved method for the synthesis of Ferric Citrate and also to provide an amorphous form of Ferric Citrate having an active surface area less than 14 sq.m/g.
专利号:US-8088602-B1 优先权日:2001-12-05 标题 :Manipulation of RNA stability and protein synthesis using thio-phosphate 发明人:FRAYNE ELIZABETH GAY 权利人:FRAYNE ELIZABETH GAY 摘要:The present invention describes the use of thio-phosphate as a novel metabolite for chemically modifying mRNA in cells. Thio-phosphate is taken up by both prokaryotic and eukaryotic cells, incorporated into rNTP pools and ultimately mRNA. This enables the in vivo modification of mRNA with nuclease resistant phosphorothioate internucleotide linkages. Significant incorporation of thio-phosphate occurs such that RNA is significantly stabilized from degradation both in vivo and in vitro upon subsequent isolation. Thio-phosphate can be used as the sole source of phosphate in the culture medium for several generations resulting in a significant increase in the amount of mRNA per cell. The method should facilitate the detection and analysis of mRNA for research and diagnostic purposes. To enhance protein production it is necessary to use a mixture of thio-phosphate and phosphate in the culture medium. Generally a specific ratio of thio-phosphate to phosphate results in the optimal synthesis of many proteins for a given organism. Significant increases in both native and recombinant proteins are possible with the use of thio-phosphate in the culture media. The method represents a significant advance for cell culture with the potential to not only enhance a variety of fermentation reactions but to also potentially stimulate cellular differentiation for a variety of therapeutic purposes.
专利号:US-6362009-B1 优先权日:1997-11-21 标 题 :Solid phase synthesis of heterocycles 发明人:MUNOZ BENITO; CHEN CHIXU 权利人:MERCK & CO INC 摘要:Methods for solid phase and combinatorial synthesis using a resin activation/capture approach are provided. In particular, methods for the production of dihydropyridones, N-acyidihydropyridones, tetrahydropyridones, pyridines, aminopyridines, N-acyltetrahydropyridines and tetrahydropyridines compounds and libraries containing such compounds are provided. Methods for screening the libraries and compounds and pharmaceutical compositions containing compounds prepared by the methods are provided.