CAS: 3420-72-2; 1-(2-Hydroxy-4,6-Dimethoxyphenyl)-3-(4-Methoxyphenyl)Prop-2-En-1-One
该化合物是属于铬类的合成有机化合物,其特点是其独特的结构,包括一个有三种甲氧基和氢氧组的铬骨柱,其特征包括三甲基氧基和氢氧基,这种化合物通常具有黄色至橙色,因其共聚双份结合系统而在铬中很常见,以其潜在的生物活动闻名,包括抗氧化剂,抗炎和抗癌特性,因此对药物研究感兴趣.多种甲氧基化合物的存在会增加其在有机溶剂中的溶解性,并可能影响其与生物目标的再活动与互动.此外,氢氧基化合物可参与氢联结,这可能会影响其药用皮酸特性.
- 英文名称1-(2-Hydroxy-4,6-Dimethoxyphenyl)-3-(4-Methoxyphenyl)Prop-2-En-1-One
- 中文名称2′-羟基-4,4′,6′-三甲氧基查耳酮
- IUPAC名称(E)-1-(2-hydroxy-4,6-dimethoxyphenyl)-3-(4-methoxyphenyl)prop-2-en-1-one
- 其它别名1-(2-Hydroxy-4,6-Dimethoxyphenyl)-3-(4-Methoxyphenyl)Prop-2-En-1-One; Flavokawain A; Flavokawin A; (E)-1-(2-Hydroxy-4,6-Dimethoxyphenyl)-3-(4-Methoxyphenyl)Prop-2-En-1-One; 1-(2-Hydroxy-4,6-Dimethoxyphenyl)-3-(4-Methoxyphenyl)-2-Propen-1-One; 2'-Hydroxy-4,4',6'-Trimethoxy; 4-Methoxybenzylidene(4,6-Dimethoxy-2-Hydroxyacetophenone); (2E)-1-(2,4-Dimethoxy-6-Hydroxyphenyl)-3-(4-Methoxyphenyl)-2-Propene-1-One
- CAS编号3420-72-2
- MFCD编号:MFCD00017174
- EINECS号:636-475-1
- FDA UNII编号:8OM2XZ2ZM3
- 分子式:C18H18O5分子量:314.34
- 产品CID: 1343162
- 产品分类天然产物 → 查尔酮类化合物
物理性质
- 熔点112-116 °C(文献)
- 沸点529.9±50.0 °C at 760 mmHg
- 闪点193.2±23.6 °C
- 密度1.2±0.1 g/cm3
- pKa:6.78±0.40(预测)
- PSA:64.99
- LogP:3.96
- 折射率1.600
- 蒸汽压0.0±1.4 mmHg at 25°C
- 溶解性Chloroform (Slightly), Methanol (Slightly)
- 敏感性常温常压下稳定
- 外观形态淡黄色至淡黄色固体
- 储存条件2-8°C
- 产品应用该化合物用于合成22","2","4-二羟基-4,44,4*,4/4},6′6/HEXAMETHXY[5,5]BICHALCONES和3-溴-4,4.,6._-TREMETHOXY-2-HYOXYCONE.
MSDS等安全信息
欧盟法规
ECHA物质C&L通报上下游产品
2-hydroxy-4,6-dimethoxyacetophenone 4-methoxy-benzaldehyde 2,4,6-trihydroxyacetophenone 3,5-dihydroxyphenol (E)-1-(2-{3,5-Dimethoxy-2-[(E)-3-(4-methoxy-phenyl)-acryloyl]-phenoxymethoxy}-4,6-dimethoxy-phenyl)-3-(4-methoxy-phenyl)-propenone 5,7-Dihydroxy-2-(4-hydroxy-phenyl)-chroman-4-on 4',5,7-trimethoxyflavone 4',5,7-trimethoxyflavanone合成工艺路线路线简述
📜2,4,6-三羟基苯乙酮一水合物置于potassium Carbonate,Barium(II) Hydroxide体系中,用 乙醇,丙酮 用作溶剂,化学反应 2.0H,反应生成2'-羟基-4,4',6'-三甲氧基查耳酮
参考文献:通过黄烷的5-O-糖基化反应从沉香沉香中分离出的总甙
标题:通过黄烷的5-O-糖基化反应从沉香沉香中分离出的总甙
摘要:Agalloside(1)是我们小组使用固定化hes1的珠子从沉香中分离得到的神经干细胞分化激活剂.我们进行agalloside(第一全合成1)经由5-ø的黄烷-Glycosylation 25使用糖基氟化物20在bf的存在3 .的et 2 O.用ddq随后的氧化,以黄烷酮2和脱保护依次agalloside提供(1).该合成策略有望用于合成5-O-糖基化的类黄酮.合成的galloloside(1)加速了神经干细胞的分化,其结果可与天然化合物1媲美.
Doi:10.1039/c7Ob01004D
海关参考信息
- 2901210000-乙烯
2901220000-丙烯
2902500000-苯乙烯
2902600000-乙苯 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-9061984-B2
优先权日:2008-08-15
标题 :Compounds related to chalcones and benzothienopyrimidines, their synthesis, and uses to treat diseases
发明人：HAMMOND GERALD B; APONTE JOSE C; GILMAN ROBERT H; SAUVAIN MICHEL HENRI AUGUSTE; VAISBERG ABRAHAM
权利人:HAMMOND GERALD B; APONTE JOSE C; GILMAN ROBERT H; SAUVAIN MICHEL HENRI AUGUSTE; VAISBERG ABRAHAM; UNIV LOUISVILLE RES FOUND; UNIV PERUMA CAYETANO HEREDIA; INST RECH POUR LE DÉVELOPPEMENT; UNIV JOHNS HOPKINS
摘要:Embodiments of the present invention provide compounds (such as Formula (I) compounds, Formula (II) compounds, and various embodiments thereof). Compositions comprising those compounds are also provided. Methods for their preparation are included. Also, uses of the compounds are included, such as administering and treating diseases (e.g., cancer and infections).
专利号:CA-3111403-A1
优先权日:2018-09-17
标 题:Matter of composition, synthesis, formulation and application of fl118 platform positions 7 and 9-derived analogues for treatment of human disease
专利号:WO-2020061106-A4
优先权日:2018-09-17
标题:Matter of composition, synthesis, formulation and application of fl118 platform positions 7 and 9-derived analogues for treatment of human disease
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
参考标题:Synthesis Of Flavokawain Analogues And Their Anti-Neoplastic Effects On Drug-Resistant Cancer Cells Through Hsp90 Inhibition作者:Young Ho Seo,Sun You Park |发布日期:2014.4.20
摘要:Hsp90 Is An Ubiquitous Molecular Chaperone Protein, Which Plays An Important Role In Regulating Maturation And Stabilization Of Many Oncogenic Proteins. Due To Its Potential To Simultaneously Disable Multiple Signaling Pathways, Hsp90 Represents Great Promise As A Therapeutic Target Of Cancer. In This Study, We Synthesized Flavokawain Analogues And Evaluated Their Biological Activities Against Drug-Resistant Cancer Cells. The Study Indicated That Compound 1I Impaired The Growth Of Gefitinib-Resistant Non-Small Cell Lung Cancer (H1975), Down-Regulated The Expression Of Hsp90 Client Proteins Including Egfr, Her2, Met, Akt And Cdk4, And Upregulated The Expression Of Hsp70. The Result Strongly Suggested That Compound 1I Inhibited The Proliferation Of Cancer Cells Through Hsp90 Inhibition. Overall, Compound 1I Could Serve As A Potential Lead Compound To Overcome The Drug Resistance In Cancer Chemotherapy.
合成参考文献
参考文献:10.1107/s1600536810042674
摘要:Sirat HM, Feng YS, Hazni H, Awang K, Ng SW. (E)-1-(2-Hy-droxy-4,6-dimeth-oxy-phen-yl)-3-(4-meth-oxy-phen-yl)prop-2-en-1-one from Kaempferia rotunda Val. Acta Crystallogr Sect E Struct Rep Online. 2010 Oct 30;66(Pt 11):o2944.
📝 需求与反馈
尽可能描述清楚需求与问题信息
