CAS: 3099-28-3; 2,6-Bis(Chloromethyl)Pyridine

该化合物是一种化学化合物,其特点是在2和6个位置用两种氯甲基组状取代了环,这种化合物一般是无色的,可粉黄液或固体,视其形态和纯度而定;由于存在氯甲基组,可进行核生殖替代反应,使其在有机合成中有用,并作为生产各种药品和农用化学品的一个中间体;该化合物在有机溶剂中可中略溶,但在水中溶解度有限;在处理该物质时,安全考虑十分重要,因为它可能会刺激皮肤,眼睛和呼吸系统,应采取适当的预防措施,以尽量减少接触;此外,必须将其储存在一个冷干燥的地方,远离不相容的材料,以确保稳定性和安全性.

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相似化合物

55422-79-2 3099-29-4 6959-47-3

物理性质

MSDS等安全信息

欧盟法规

ECHA物质C&L通报

上下游产品

CAS号1195-59-1 2,6-吡啶二甲醇 | CAS号5453-67-8 2,6-吡啶二甲酸二甲酯 | CAS号108-48-5 2,6-二甲基吡啶 | CAS号15658-60-3 2,6-吡啶二羧酸二乙酯 | CAS号499-83-2 2,6-吡啶二羧酸 | CAS号102363-19-9 3,7,11,17-tetra... | CAS号25117-68-4 3,11-Dithia-17,... | CAS号1195-59-1 2,6-吡啶二甲醇 | CAS号201160-41-0 Pyridine, 2,6-b... | CAS号73892-45-2 2,6-双[(二苯基膦基)甲基]吡啶 | CAS号66433-94-1 2,6-bis(phenoxy... | CAS号66433-95-2 2-[[6-[(2-formy... | CAS号66433-99-6 2,6-bis[(2-meth... | CAS号84203-61-2 2,6-bis(methyls... | CAS号85932-62-3 trimethyl-[[6-(...

合成工艺路线路线简述

    📜吡啶-2.6-二羧酸二甲酯置于sodium Tetrahydroborate,氯化亚砜体系中,用 甲醇,苯 用作溶剂,化学反应生成2,6-二氯甲基吡啶
    参考文献:大环二氧戊胺:用于 1:1 镍 (II)-氧 (Ni(II)-O2) 加合物形成的新型配体
    标题:大环二氧戊胺:用于 1:1 镍 (II)-氧 (Ni(II)-O2) 加合物形成的新型配体
    摘要:La Pentaaza-1,4,7,10,13 Cyclohexadecanedione-14,16 Forme Des Complexes Stables 1:1 Avec Ni(II) Et Cu(II) Possedant 2 Donneurs Deprotones En Position Equatoriale.Calcul Des Potentiels氧化还原.Cinetique De La Fixation D'O 2 Ensolutions Aqueuses
    Doi:10.1021/ja00331A018

    海关参考信息

    专利信息


    专利号:US-2009111737-A1
    优先权日:1999-05-24
    标题:Novel antibacterial agents
    发明人：CHRISTENSEN BURTON G; MORAN EDMUND J; GRIFFIN JOHN H; JUDICE J KEVIN; MU YONGQI; PACE JOHN L; MAMMEN MATHAI; AGGEN JAMES
    权利人:CHRISTENSEN BURTON G; MORAN EDMUND J; GRIFFIN JOHN H; JUDICE J KEVIN; MU YONGQI; PACE JOHN L; MAMMEN MATHAI; AGGEN JAMES
    摘要:This invention relates to novel multibinding compounds (agents) that are antibacterial agents. The multibinding compounds of the invention comprise from 2-10 ligands covalently connected by a linker or linkers, wherein each of said ligands in their monovalent (i.e., unlinked) state have the ability to bind to a an enzyme involved in cell wall biosynthesis and metabolism, a precursor used in the synthesis of the bacterial cell wall and/or the bacterial cell surface thereby interfere with the synthesis and/or metabolism of the cell wall. In particular the multibinding compounds of the invention comprise from 2-10 ligands covalently connected by a linker or linkers, wherein each of said ligands hasn a ligand domain capable of binding to penicillin binding proteins, a transpeptidase enzyme, a substrate of a transpeptidase enzyme, a beta-lactamase enzyme, pencillinase enzyme, cephalosporinase enzyme, a transglycoslase enzyme, or a transglycosylase enzyme substrate; Preferably, the ligands are selected from the beta lactam or glycopeptide class of antibacterial agents.

    专利号:EP-1480979-B1
    优先权日:2002-03-05
    标 题 :Gadolinium chelate oligomers, their use as contrast products in magnetic resonance imaging and their synthesis intermediates
    发明人：NACHMAN ISABELLE; PORT MARC; RAYNAL ISABELLE; ROUSSEAUX OLIVIER
    权利人:GUERBET SA
    摘要:The invention relates to high-relaxivity macrocyclic gadolinium chelate oligomers of formula W-(A)m in which W, A and m are as defined in claim 1 , and their use as a blood pool contrast product for magnetic resonance imaging.

    专利号:US-7179794-B2
    优先权日:1998-06-08
    标题 :Multivalent macrolide antibiotics
    发明人：GRIFFIN JOHN H; PACE JOHN L
    权利人:THERAVANCE INC
    摘要:Disclosed are multibinding compounds which include macrolide antibiotics, aminoglycosides, lincosamides, oxazolidinones, streptoramins, tetracycline and/or other compounds which bind to bacterial ribosomal RNA and/or to one or more proteins involved in ribosomal protein synthesis in the bacterium, which are useful in treating bacterial infections. The compounds adversely affect protein expression and have an antibacterial effect. The multibinding compounds of this invention containing from 2 to 10 ligands covalently attached to one or more linkers. Each ligand is macrolide antibiotic, aminoglycoside, lincosamide, oxazolidinone, streptogramin, tetracycline or other compound which binds to bacterial ribosomal RNA and/or one or more proteins involved in ribosomal protein synthesis in the bacterium.

    专利号:US-2007098643-A1
    优先权日:2002-03-05
    标 题 :Oligomers of gadolinium chelates, their applicationascontrast products in magnetic resonance imaging and their synthesis intermediates

    专利号:RU-2194703-C2
    优先权日:1997-07-17
    标题:Hypoglycemic medicinal agent comprising pyrazine derivatives, novel derivatives of pyrazine and methods of their synthesis

    专利号:CN-114425311-A
    优先权日:2022-02-21
    标 题:Porous adsorption material based on recycling of alcohol-soluble waste in production process of polyphenyl ether and synthesis method thereof

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    合成参考文献


    参考文献:10.1016/j.saa.2007.12.052
    摘要:Shukla D, Gupta LK, Chandra S. Spectroscopic studies on chromium(III), manganese(II), cobalt(II), nickel(II) and copper(II) complexes with hexadentate nitrogen–sulfur donor [N2S4] macrocyclic ligand. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy. 2008 Dec;71(3):746–50. doi: 10.1016/j.saa.2007.12.052.
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