CAS: 25612-59-3; (R)-2,8-Dimethyl-2-((3E,7E)-4,8,12-Trimethyltrideca-3,7,11-Trien-1-yl)Chroman-6-Ol

上下游产品

2'-phenylsulfonyl-δ-t°Cotrienyl benzyl ether methyl 2,8-dimethyl-6-benzoyloxychroman-2-carboxylate 2,8-dimethyl-6-hydroxychroman-2-methanol 16H20O6C16H20O6(R)-2,8-dimethyl-2-((3'E,7'E)-4',8',12'-trimethyltrideca-3',7',11'-trienyl)chroman-6-yl tosylcarbamate (R)-2,8-dimethyl-2-((3'E,7'E)-4',8',12'-trimethyltrideca-3',7',11'-trienyl)chroman-6-yl phenylcarbamate (R)-2,8-dimethyl-2-((3'E,7'E)-4',8',12'-trimethyltrideca-3',7',11'-trienyl)chroman-6-yl 4-chlorophenylsulfonylcarbamate (R)-2,8-dimethyl-2-((3'E,7'E)-4',8',12'-trimethyltrideca-3',7',11'-trienyl)chroman-6-yl benzylcarbamate

📜4-羟基-3-甲基苯基苯甲酸酯置于吡啶,六甲基磷酰三胺,Lithium Hydroxide,Lithium Aluminium Tetrahydride,正丁基锂,Lithium,Potassium Carbonate,二正丁胺,溶剂黄146,甲胺体系中,用 四氢呋喃,甲醇,乙醚,正己烷,N,N-二甲基甲酰胺 用作溶剂,化学反应 51.16H,反应生成δ-生育三烯醇
参考文献:短而便捷的化学路线,即可制得光学纯的2-甲基氯代甲醇.β-,γ-和δ-生育三烯酚的总不对称合成
标题:短而便捷的化学路线,即可制得光学纯的2-甲基氯代甲醇.β-,γ-和δ-生育三烯酚的总不对称合成
摘要:使用廉价的可商购的原料,已经以高收率制备了天然β-,γ-和δ-生育三烯酚的苯甲醇甲醇前体.酶促拆分得到高对映体过量的手性苯并二甲醇.法呢基侧链的后续附接是高产率的,因此允许在最后的步骤中制备不对称的β-,γ-和δ-生育三烯酚,其中同时发生苯酚的脱保护和砜基的去除.该化学方法提供了天然系列β-生育三烯酚的首次合成.
Doi:10.1021/jo0705418

专利信息

专利号:US-2008221377-A1
优先权日:2006-06-16
标题 :Methods for synthesis of carotenoids, including analogs, derivatives, and synthetic and biological intermediates
发明人：LOCKWOOD SAMUEL F; TANG PENG CHO; NADOLSKI GEOFF; JACKSON HENRY L; FANG ZHIQIANG; DU YISHU; YANG MIN; GEISS WILLIAM; WILLIAMS RICHARD; BURDICK DAVID; BRAUN CRISTI L
权利人:LOCKWOOD SAMUEL F; TANG PENG CHO; NADOLSKI GEOFF; JACKSON HENRY L; FANG ZHIQIANG; DU YISHU; YANG MIN; GEISS WILLIAM; WILLIAMS RICHARD; BURDICK DAVID; BRAUN CRISTI L
摘要:A method for synthesizing intermediates for use in the synthesis of carotenoid synthetic intermediates, carotenoid analogs, and/or carotenoid derivatives. The carotenoid analog, derivative, or intermediate may be administered to a subject for the inhibition and/or amelioration of any disease that involves production of reactive oxygen species, reactive nitrogen species, radicals and/or non-radicals. In some embodiments, the invention may include methods for synthesizing chemical compounds including an analog or derivative of a carotenoid. Carotenoid analogs or derivatives may include acyclic end groups. In some embodiments, a carotenoid analog or derivative may include at least one substituent. The substituent may enhance the solubility of the carotenoid analog or derivative such that the carotenoid analog or derivative at least partially dissolves in water.

专利号:US-9981935-B2
优先权日:2013-07-05
标 题:Formation of chiral 4-chromanones using chiral pyrrolidines in the presence of acids
发明人：MEDLOCK JONATHAN ALAN; LETINOIS ULLA; NETSCHER THOMAS; BONRATH WERNER
权利人:DSM IP ASSETS BV
摘要:The present invention relates to a synthesis of chromanones or chromanes in a stereospecific matter in view of the 2-position in the chromanone or chromane ring. It has been found that this synthesis is particularly possible in the presence of a chiral compound of a specific type and of at least one Bransted acid or in the presence a specific chiral compound having a Bransted acid functional group in the molecule.

专利号:US-9815809-B2
优先权日:2013-07-05
标题:Formation of chiral 4-chromanones using chiral pyrrolidines in the presence of phenols or thiophenols
发明人：LETINOIS ULLA; NETSCHER THOMAS
权利人:DSM IP ASSETS BV
摘要:The present invention relates to a synthesis of chromanones or chromanes in a stereospecific matter in view of the 2-position in the chromanone or chromane ring. It has been found that this synthesis is particularly possible in the presence of a chiral compound of formula of a specific type and of at least one phenol or thiophenol.

专利号:US-9809565-B2
优先权日:2013-07-05
标 题 :Formation of chiral 4-chromanones using chiral pyrrolidines in the presence of ureas or thioureas
发明人：LETINOIS ULLA; NETSCHER THOMAS; ACKERMANN STEPHAN
权利人:DSM IP ASSETS BV
摘要:The present invention relates to a synthesis of chromanones or chromanes in a stereospecific matter in view of the 2-position in the chromanone or chromane ring. It has been found that this synthesis is particularly possible in the presence of a chiral compound of formula of a specific type and of at least one urea or thiourea.

专利号:US-2003157592-A1
优先权日:1999-12-16
标题:Moss genes from physcomitrella patens encoding proteins involved in the synthesis of tocopherols and carotenoids
发明人：LERCHL JENS; RENZ ANDREAS; EHRHARDT THOMAS; REINDL ANDREAS; CIRPUS PETRA; BISCHOFF FRIEDRICH; FRANK MARKUS; FREUND ANNETTE; DUWENIG ELKE; SCHMIDT RALF-MICHAEL; RESKI RALF; BADUR RALF
摘要:Isolated nucleic acid molecules, designated TCMRP nucleic acid molecules, which encode novel TCMRPs from e.g. Phycomitrella patens are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing TCMRP nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further provides isolated TCMRPs, mutated TCMRPs, fusion proteins, antigenic peptides and methods for the improvement of production of a desired compound from transformed cells, organisms or plants based on genetic engineering of TCMRP genes in these organisms.

专利号:US-11673874-B2
优先权日:2018-08-17
标 题 :Synthesis of chromanol derivatives
发明人：WEINGARTEN MELANIE; SIEGEL WOLFGANG; PUHL MICHAEL
权利人:BASF SE
摘要:The present invention relates to a process for the production of chromanol derivatives, more specifically to a process for preparing a compound of the general formula I wherein R 1 , R 2 and R 3 independently of each other are selected from hydrogen and methyl, R 4 is selected from C- 1 -C 6 -alkyl, and X is selected from C 1 -C 20 -alkyl and C 2 -C 20 -alkenyl.