CAS: 22924-15-8; 3-Ethoxybenzaldehyde

上下游产品

CAS号75-03-6 碘乙烷 | CAS号100-83-4 间羟基苯甲醛 | CAS号584-08-7 碳酸钾 | CAS号621-32-9 Benzene, 1-etho... | CAS号110207-92-6 1-(chloromethyl... | CAS号893581-62-9 (3-乙氧基苯基)-N-甲基甲胺 | CAS号103986-73-8 反-3-乙氧基肉桂酸 | CAS号621-51-2 3-乙氧基苯甲酸 | CAS号25117-75-3 3-乙氧基苯甲腈 | CAS号71648-21-0 (3-乙氧基苯基)甲醇 | CAS号90943-37-6 3-ETHOXY BENZAL... | CAS号55977-09-8 3,3-二羟基黄酮

碘乙烷,间羟基苯甲醛置于sodium Methylate体系中,用 甲醇 用作溶剂,化学反应 16.0H,以66%的收率获得3-乙氧基苯甲醛
参考文献:手性n,N-二取代的三氟-3-氨基-2-丙醇是有效的胆固醇酯转移蛋白抑制剂.
标题:手性n,N-二取代的三氟-3-氨基-2-丙醇是有效的胆固醇酯转移蛋白抑制剂.
摘要:描述了可逆地抑制胆固醇酯转移蛋白(cetp)的一系列新的取代的n-苄基-N-苯基-三氟-3-氨基-2-丙醇.从筛选铅22开始,就抑制cetp介导的[(3)h]胆固醇从高密度胆固醇供体颗粒向低密度胆固醇受体颗粒的转移进行了探索,探讨了各种结构特征.丙醇的游离羟基是高效试剂所必需的,因为酰化或烷基化会降低活性.苯胺环中的3-醚部分也具有高抑制效力,而3-苯氧基苯胺类似物表现出最高的效力.活性通过苄基的亚甲基中的氧化或取代而大大降低,这表明苄基环取向对活性很重要.在苄基中,在3-位的取代优于在2-或4-位.在抑制剂中观测到最高的效力,其中3-苄基取代基具有相对​​于苯环采用平面外取向的潜力.最好的3-苄基取代基是ocf(2)cf(2)h(42,Ic(50)缓冲液中0.14 Microm,人血清中5.6 Microm),环戊基(39),3-异丙氧基(27),Scf (3)(67)和c(cf(3))
Doi:10.1021/jm020038H

专利信息

专利号:US-6251689-B1
优先权日:1998-05-14
标 题:Methods for the solid phase synthesis of combinatorial libraries of benzimidazoles benzoxazoles benzothiazoles and derivatives thereof
发明人：LABORDE EDGARDO; MATSUMOTO YUKIHARU
权利人:TELIK INC
摘要:The present invention provides an efficient and versatile method for the synthesis and screening of combinatorial libraries of benzimidazoles, benzoxazoles, benzothiazoles, and derivatives thereof. In order to expedite the synthesis of large arrays of compounds possessing these core structures, a general methodology for solid phase synthesis of these derivatives is provided. Arrays of benzimidazoles, benzoxazoles, benzothiazoles, and derivatives thereof useful as peptidomimetics and for the identification of agents having antifungal, antiviral, antimicrobial, anticoagulant, and antiulcer activity, or use in the treatment of inflammation, hypertension, cancer, and other conditions can be prepared by this method.

专利号:US-5861532-A
优先权日:1997-03-04
标 题:Solid-phase synthesis of N-alkyl amides
发明人：BROWN EDWARD G; NUSS JOHN M
权利人:CHIRON CORP
摘要:Methods for solid phase synthesis of N-alkyl amides comprise reductive amination of carbonyl compounds using a reducing agent and an amine-containing linker bound to a solid support. The methods afford high yields of linker-bound, monoalkylated amines, and subsequent coupling with acid derivatives provide derivatized N-substituted amides in excellent yields after cleavage from the solid-phase. Compositions useful in solid phase synthesis are also described.

专利号:US-4582903-A
优先权日:1984-08-17
标 题 :Synthesis of unsaturated hydantoins with an inexpensive catalyst
发明人：MIRVISS STANLEY B
权利人:STAUFFER CHEMICAL CO
摘要:Alkylidene or arylidene substituted hydantoins are produced by condensation of an aromatic or aliphatic aldehyde with hydantoin in the presence of at least one basic salt of an inorganic acid. The desired products are obtained in high yields.

专利号:CN-104804003-A
优先权日:2015-04-27
标题 :Synthesis of 5-aryl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one

专利号:US-8558012-B2
优先权日:2009-03-02
标 题:2-fluoro-1,3-benzodithiol 1,1,3,3-tetraoxide derivative, production method thereof, and production method of monofluoromethyl group-containing compound using the same
发明人：SHIBATA NORIO
权利人:SHIBATA NORIO; NAGOYA INST TECHNOLOGY; TOSOH P TECH INC
摘要:A 2-fluoro-1,3-benzodithiol 1,1,3,3-tetraoxide derivative as a monofluoromethyl group introduction agent that is effective as an intermediate in pharmaceutical and agrochemical synthesis, a production method thereof, and a production method of a monofluoromethyl group-containing compound using this 2-fluoro-1,3-benzodithiol 1,1,3,3-tetraoxide derivative are provided. The 2-fluoro-1,3-benzodithiol 1,1,3,3-tetraoxide derivative represented by the following general formula (1) (wherein R 1 , R 2 , R 3 , and R 4 each independently represent a hydrogen atom, a straight-chain or branched alkyl group having 1 to 4 carbon atoms, a straight-chain or branched alkyloxy group having 1 to 4 carbon atoms, a halogen atom, a nitro group, or a cyano group), the production method thereof, and various monofluoromethyl group-containing compounds are manufactured using this 2-fluoro-1,3-benzodithiol 1,1,3,3-tetraoxide derivative as a monofluoromethylating agent.

专利号:US-2001024833-A1
优先权日:1998-05-14
标 题 :Methods for the solid phase synthesis of combinatorial libraries of benzimidazol, benzoxazoles, benzothiazoles, and derivatives thereof