CAS: 22350-43-2; (S)-4-Methyl-3-((E)-2-((1R,7Ar)-7A-Methyl-1-((R)-6-Methylheptan-2-yl)-2,3,5,6,7,7A-Hexahydro-1H-Inden-4-yl)Vinyl)Cyclohex-3-En-1-Ol

上下游产品

3vitamin D3 methanol S,7Ξ,10Ξ)-7,10-epidioxy-9,10-seco-cholest-5-en-3-ol(3S,7Ξ,10Ξ)-7,10-epidioxy-9,10-seco-cholest-5-en-3-olS)-3-(4-methyl-3,5-dinitro-benzoyloxy)-9,10-seco-cholesta-5(10),6t,8(14)-triene(3S)-3-(4-methyl-3,5-dinitro-benzoyloxy)-9,10-seco-cholesta-5(10),6t,8(14)-triene

📜维生素 D3置于盐酸体系中,用 甲醇 用作溶剂,化学反应 0.5H,以75%的收率获得异速甾醇3
参考文献:Jin,Xiaoling; Yang,Xinping; Yang,Li,Journal Of Chemical Research-Part S,2003,# 8,P. 477-479
标题:Jin,Xiaoling; Yang,Xinping; Yang,Li,Journal Of Chemical Research-Part S,2003,# 8,P. 477-479

专利信息

专利号:US-2012258938-A1
优先权日:2008-02-28
标题:Enzymatic Production or Chemical Synthesis and Uses for 5,7-Dienes and UVB Conversion Products Thereof
发明人：SLOMINSKI ANDREJ; TUCKEY ROBERT C; TANG EDITH; TIEU ELAINE; NGUYEN MINH; JANJETOVIC ZORICA; CHEN JIANJUN; LI WEI; LU YAN; MILLER DUANE D; ZJAWIONY JORDAN K; POSTLETHWAITE ARNOLD E
权利人:SLOMINSKI ANDREJ; TUCKEY ROBERT C; TANG EDITH; TIEU ELAINE; NGUYEN MINH; JANJETOVIC ZORICA; CHEN JIANJUN; LI WEI; LU YAN; MILLER DUANE D; ZJAWIONY JORDAN K; POSTLETHWAITE ARNOLD E
摘要:Provided herein are steroidal compounds that are androsta-5,7-dienes or pregna-5,7-dienes and ultraviolet B (UVB) conversion products thereof and cholecalciferol derivatives hydroxylated at one or more of C1, C17, C20, C23, C24, C25, and C26 which includes pharmaceutical, cosmeceutical or nutraceutical compositions of the steroidal compounds as shown in Tables 1A, 2A and 3. Also provided is a method for producing hydroxylated metabolites of cholecalciferol via CYP11A1, CYP24, CYP27A1, or CYP27B1 enzyme systems where the hydroxylase has an activity to hydroxylate position C1 or C20 or other position of the sidechain of a secosteroid or its 5,7-dieneal precursor and the hydroxylated metabolites so produced. Methods are provided for inhibiting proliferation of either a normally or abnormally proliferating cell, for modifying immune activity, or for treating a condition associated with the proliferating or quiescent cell or immune cells by contacting the cell with or administering any of the compounds described herein.

专利号:US-2014200201-A1
优先权日:2008-02-28
标题 :Enzymatic Production or Chemical Synthesis and Uses for 5,7-Dienes and UVB Conversion Products Thereof
发明人：SLOMINSKI ANDRZEJ T; TUCKEY ROBERT C; ZBYTEK BLAZEJ; ZMIJEWSKI MICHAL A; NGUYEN MINH NGOC; JANJETOVIC ZORICA; CHEN JIANJUN; LI WEI; MILLER DUANE D; ZJAWIONY JORDAN K; POSTLETHWAITE ARNOLD E; SWEATMAN TREVOR W
权利人:SLOMINSKI ANDRZEJ T; TUCKEY ROBERT C; ZBYTEK BLAZEJ; ZMIJEWSKI MICHAL A; NGUYEN MINH NGOC; JANJETOVIC ZORICA; CHEN JIANJUN; LI WEI; MILLER DUANE D; ZJAWIONY JORDAN K; POSTLETHWAITE ARNOLD E; SWEATMAN TREVOR W
摘要:Provided herein are steroidal compounds that are androsta-5,7-dienes or a pregna-5,7-dienes and ultraviolet B (UVB) conversion products thereof which includes pharmaceutical compositions of the steroidal compounds as shown in Tables 1 and 2. Also provided is a method for producing hydroxylated metabolites of cholecalciferol or ergocalciferol via the P450scc (CYP11A1) or CYP27B1 enzyme systems where the hydroxylase has an activity to hydroxylate position C20 of a secosteroid or its 5,7-dieneal precursor and the hydroxylated metabolites so produced. In addition, a method for inhibiting proliferation of either a normally or abnormally proliferating cell by contacting the cell with any of the compounds described herein. A related method is provided of treating a condition associated with the proliferating cell such as a cancer, a skin disorder, a defect in cell differentiation, cosmetic, prophylaxsis, or healthy cell maintenance.