CAS: 2150-47-2; Methyl 2,4-Dihydroxybenzoate

上下游产品

CAS号67-56-1 甲醇 | CAS号89-86-1 2,4-二羟基苯甲酸 | CAS号106315-78-0 methyl 2,4-diac... | CAS号74-88-4 碘甲烷 | CAS号102342-54-1 1,3,5-tris(trim... | CAS号149-73-5 原甲酸三甲酯 | CAS号106315-78-0 methyl 2,4-diac... | CAS号33662-58-7 甲基2,4-二羟基-3-苯甲酸乙酯 | CAS号608-25-3 2,6-二羟基甲苯 | CAS号387-46-2 2,6-二羟基苯甲醛 | CAS号98-95-3 硝基苯 | CAS号148965-89-3 2-羟基-4-[(4-甲氧基苄... | CAS号17771-33-4 7-羟基-2,2-二甲基-苯并... | CAS号190278-38-7 methyl 5-bromo-... | CAS号2373-34-4 2H-1-Benzopyran...

Methyl 2,4-Diacetoxybenzoate置于trimethyltin Hydroxide体系中,用 1,2-二氯乙烷 用作溶剂,化学反应 5.0H,以100%的收率获得2,4-二羟基苯甲酸甲酯
参考文献:用氢氧化三甲基锡水解酯的温和选择性方法.
标题:用氢氧化三甲基锡水解酯的温和选择性方法.
摘要:
Doi:10.1002/anie.200462207

专利信息

专利号:US-3836544-A
优先权日:1972-04-25
标 题:Synthesis of zearalanes ii and related compounds and intermediates useful in the syntheses thereof
发明人：URRY W; MULLENBACH G
权利人:COMMERCIAL SOLVENTS CORP
摘要:THIS INVENTION PROVIDES A NEW SYNTHESIS FOR NORZEARALANE II AND RELATED COMPOUNDS WHICH RELATED COMPOUNDS AND NORZEARALANE II ARE REPRESENTED BY THE FORMULA 1,5-DI(HO-),2,3-(-CO-O-CH2-(CH2)X-)-BENZENE WHERE X IS AN INTEGER HAVING A VALUE FROM 1 TO 13 INCLUSIVE. THE ANABOLIC AGENT NORZEARALANE II, IN WHICH X=9 IN THEFOREGOING FORMULA, IS PREPARED BY A TOTAL CHEMICAL SYNTHESIS INVOLVING THE REACTION OF 10-UNDECENAL WITH MALONIC ACID TO PRODUCE TRANS-2,12-TRIDECADIENOIC ACID; TREATING THE ACID SO FORMED WITH DIAZOMSTHANE TO YIELD METHYL TRANS-2,12-TRIDECADIENOATE; REACTING THE METHYL ESTER WITH ETHYL ACETOACETATE AND SODIUM ETHOXIDE TO FORM THE SODIUM SALT OF ETHYL 6-(9-DECENYL)-B-DIHYDRORESORCYLATE; BROMINATING THE DIHYDRORESORCYLATE TO PREPARE ETHYL 3-BROMO- 6 - (9-DECENYL)-B-DIHYDRORESOCRYLATE; DE-HYDROBROMINATING THE FOREGOING BROMO DERIVATIVE TO GIVE ETHYL 6-(9-DECENYL)-B-RESORCYLATE; REACTING THE RESORCYLATE ESTER WITH BENZYL CHLORIDE TO PRODUCE ETHYL 6-(9-DECENYL)-BRESORCYLATE DIBENZYL ETHER; SUBJECTING THE BENZYLATED ESTER TO THE ACTION OF DIBORANE, WATER AND HYDROGEN PEROXIDE TO FORM ETHYL 2,4-BIS (BENZYLOXY)-6-(10-HYDROXYDECYL)BENZOATE; TREATING THE FOREGOING BENZOATE WITH SODIUM ETHOXIDE TO PREPARE NORZEARALANE II DIBENZYL ETHER, ONE ALSO TO PREPARE AS A BY-PRODUCT THE DIMERIC DILACTONE OF 2,4-BIS(BENZYLOXY)-6-(10-HYDROXYDECYL)-BENZOIC ACID; HYDROGENATING NORZEARALANE II DIBENZYL ETHER TO FORM NORZEARALANE II. IN GENERAL, A HOMOLOGUE OF NORZEARALANE II AND/OR OF THE CORRESPONDING DIMERIC DILACTONE IS PREPARED BY SUBSTITUTING FOOR 10-UNDECENAL IN THE FOREGOING SEQUENCE OF REACTIONS AN UNSATURATED ALDEHYDE HAVING THE FORMULA CH2=CH-(CH2)X-1-CHO WHERE X IS AN INTEGER WHICH MAY HAVE THE VALUE 1,2,3,4, 5, 6, 7, 8, 9, 10, 11, 12 OR 13 SPECIFICALLY ZEARALANE II (WHERE X=10) IS PREPARED STARTING WITH 11-DODECENAL AND THE DIMERIC DILACTONE FROM 6-(5-HYDROXYPENTYL-B-RESORCYCLIC ACID DIBENZYL ETHER IS PREPARED WHEN THE STARTING ALDEHYDE IS 5-HEXENAL (WHERE X= 4) THE INVENTION ALSO COVERS PHYSIOLOGICALLY ACTIVE COMPOUNDS RELATED TO THE ZEARALANES II AND KNOW AS DIMERIC DILACTONES HAVING THE FORMULA, 1,5-DI(RO-),2,3-(-CO-O-CH2-(CH2)X-(3,5-DI(RO-)-1,6-PHENYL ENE)-CO-O-CH2-(CH2)X-)-BENZENE X IS AN INTEGER WHICH MAY HAVE THE VALUE 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12 OR 13 AND WHERE R IS EITHE HYDROGEN OR A BENZYL RADICAL (C6H5CH2-). MORE PARTICULARLY, THIS INVENTION RELATES TO NOVEL INTERMEDIATES PRODUCED IN THE SYNTHESIS OF THE ABOVE COMPOUNDS AND TO PROCESSES FOR MAKING THESE INTERMEDIATES.

专利号:WO-2024185775-A1
优先权日:2023-03-06
标 题:Long-chain alkenyloxy–substituted benzoyl derivative and oligonucleotide synthesis method using same
发明人：OKADA YOHEI; INANAGA KAZATO; SHOJI Yukiya; MIZUFUNE HIDEYA; SUDO TATSUYA; ADACHI Sota; HOSOI Kazushi
权利人:SPERA PHARMA INC; TOKYO UNIV OF AGRICULTURE AND TECHNOLOGY
摘要:The purpose of the present invention is to provide a novel pseudo–solid phase protecting group that can be used in liquid-phase oligonucleotide synthesis. The purpose of the present invention is also to provide an oligonucleotide synthesis method that uses a novel pseudo–solid phase protecting group.　The present invention provides a compound represented by formula (1) (in which R represents a C14–60 alkenyl group, n represents 2 or 3, m represents 0 or 1, p represents 1 or 2, X represents C, N, O, or S, Y represents a single bond or B(CH 2 ) t * or may form a ring with X, and Z represents a single bond or (CH 2 ) s (s being an integer from 1 to 5)). The present invention also provides an oligonucleotide production method that uses the compound.

专利号:US-3903115-A
优先权日:1972-04-25
标 题 :Synthesis of zearalanes II and related compounds and intermediates useful in the syntheses thereof
发明人：URRY WILBERT H; MULLENBACH GUY TOWNS
权利人:COMMERCIAL SOLVENTS CORP
摘要:This invention provides a new synthesis for norzearalane II and related compounds which related compounds and norzearalane II are represented by the formula where X is an integer having a value from 1 to 13 inclusive. The anabolic agent norzearalane II, in which X 9 in the foregoing formula, is prepared by a total chemical synthesis involving the reaction of 10-undecenal with malonic acid to produce trans-2,12-tridecadienoic acid; treating the acid so formed with diazomethane to yield methyl trans-2,12tridecadienoate; reacting the methyl ester with ethyl acetoacetate and sodium ethoxide to form the sodium salt of ethyl 6-(9-decenyl)- Beta -dihydroresorcylate; brominating the dihydroresorcylate to prepare ethyl 3-bromo-6-(9-decenyl)- Beta dihydroresorcylate; de-hydrobrominating the foregoing bromo derivative to give ethyl 6-(9-decenyl)- Beta -resorcylate; reacting the resorcylate ester with benzyl chloride to produce ethyl 6-(9-decenyl)- Beta -resorcylate dibenzyl ether; subjecting the benzylated ester to the action of diborane, water and hydrogen peroxide to form ethyl 2,4-bis(benzyloxy)-6-(10hydroxydecyl)-benzoate; treating the foregoing benzoate with sodium ethoxide to prepare norzearalane II dibenzyl ether, and also to prepare as a by-product the dimeric dilactone of 2,4bis(benzyloxy)-6-(10-hydroxydecyl)-benzoic acid; hydrogenating norzearalane II dibenzyl ether to form norzearalane II.

专利号:US-8481519-B2
优先权日:2005-02-05
标题 :Isolation of atraric acid, synthesis of atraric acid derivatives, and use of atraric acid and the derivatives thereof for the treatment of benign prostatic hyperplasia, prostate carcinoma and spinobulbar muscular atrophy
发明人：HOFFMANN HANS-RAINER; MATUSCH RUDOLF; BANIAHMAD ARIA
权利人:HOFFMANN HANS-RAINER; MATUSCH RUDOLF; BANIAHMAD ARIA; LOHMANN THERAPIE SYST LTS
摘要:A method for isolating atraric acid from biological material, atraric acid derivatives, the chemical synthesis thereof, and the use of atraric acid and the derivatives thereof for treating or producing a medicament for treating benign prostate hyperplasia, prostate carcinoma or spinobulbar muscular atrophy is provided. In addition, a basic substance for the development of other agents used for treating benign prostate hyperplasia, prostate carcinoma, or spinobulbar muscular atrophy is provided.

专利号:WO-0061545-A1
优先权日:1999-04-14
标题 :Methods for solid phase combinatorial synthesis of integrin inhibitors
发明人：GOPALSAMY ARIAMALA; YANG HUI YU
权利人:AMERICAN HOME PROD
摘要:Compounds of the formula (I) are useful in the treatment of various disorders including, but not limited to, cancer (tumor metathesis, tumorgenesis/tumor growth), angiogenesis (as in cancer, diabetic retinopathy, rheumatoid arthritis), restenosis (following balloon angioplasty or stent implantation), inflammation (as in rheumatoid arthritis, psoriasis), bone diseases (osteopenia induced by bone metastases, immobilization and glucocortocoid treatment, periodontal disease, hyperparathyroidism and rheumatoid arthritis), and as antiviral agents. Novel method of making compounds of formula (I) are also provided.

专利号:US-4150236-A
优先权日:1976-05-26
标 题 :Steroidal intermediates from the condensation product of dimethyl-3-ketoglutarate and glyoxal
发明人：WEISS ULRICH; RICE KENNER C
权利人:US HEALTH EDUCATION & WELFARE
摘要:Tricyclic aromatic compounds of the formula ##STR1## including those wherein: (A) R 1 is H, R 2 is carbomethoxy, and R 3 is methyl; n (b) R 1 is acetyl, R 2 is carbomethoxy, and R 3 is methyl; n (c) R 1 and R 3 are methyl and R 2 is carbomethoxy; n (d) R 1 , R 2 , and R 3 are hydrogen; and n (e) R 1 and R 3 are methyl and R 2 is hydrogen n Are intermediates for the total synthesis of steroids.