CAS: 20734-76-3; 2-Amino-4-Methoxyphenol

上下游产品

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4-甲氧基-2-硝基酚 4-Methoxy-2-Nitrophenol 1568-70-3

4-甲氧基-2-硝基酚置于palladium On Activated Charcoal,氢气体系中,用 甲醇 用作溶剂,化学反应 24.0H,以97.3%的收率获得2-氨基-4-甲氧基苯酚
参考文献:新型18 F标记的2-吡啶基苯并恶唑和2-吡啶基苯并噻唑衍生物作为配体的β-淀粉样蛋白正电子发射断层显像(pet)的合成和评价
标题:新型18 F标记的2-吡啶基苯并恶唑和2-吡啶基苯并噻唑衍生物作为配体的β-淀粉样蛋白正电子发射断层显像(pet)的合成和评价
摘要:合成了一系列氟代聚乙二醇化(fpeg)2-吡啶基苯并恶唑和2-吡啶基苯并噻唑衍生物,并将其作为pet的新型β-淀粉样(aβ)成像探针进行了评估.他们表现出对aβ1-42聚集体的结合亲和力,范围从2.7到101.6 Nm.选择了七个具有高亲和力的配体进行18 F标记.体外放射自显影结果证实了这些放射性示踪剂的高亲和力.在正常小鼠中进行的体内生物分布实验表明,具有短fpeg链(n = 1)的放射性示踪剂显示出较高的初始摄入量并迅速从大脑中清除.2-吡啶基苯并恶唑衍生物之一,[ 18 F]-5-(5-(2-氟乙氧基)苯并[ D ]恶唑-2-基)-N-甲基吡啶-2-胺([ 18 F] 32)(k I = 8.0+/-3.2 Nm)的大脑2Min /大脑60Min之比为4.66,这对于aβ显像剂而言是非常理想的.[ 18 F] 32与aβ斑块的靶标特异性结合通过转基因模型小鼠的体外放射自显影实验得到验证.总体而言,[
Doi:10.1021/jm300973K

专利信息

专利号:US-2004209877-A1
优先权日:2000-04-13
标 题 :Methods for augmenting immune defenses contemplating the administration of phenolic and indoleamine-like compounds for use in animals ans humans
发明人：SHELBY NANCY J; ROSENFELD MARK J
摘要:Phenolic compounds with a phenolic molecule to which are covalently linked an oxygen-containing group, a nitrogen or another oxygen containing group, and a C 1 -C 4 alkoxy group, obtainable from monocotyledonous plants, or by chemical synthesis, have been found to preserve and/or augment innate immune defenses in humans and animals. Additional chemical compounds of the present invention may include benzoxazinoids-cyclic hydroxyamic acids, lactams, and corresponding glucosides, which may serve as precursors to phenolic compounds. The phenolic compounds and precursors of phenolic compounds of the present invention, at concentrations suitable for human and animal therapeutic use, may be obtained from monocotyledonous plants such as corn in their early growth states which are timely harvested for optimum yield.

专利号:WO-2024126786-A1
优先权日:2022-12-15
标 题 :Process for preparing allylic alcohol
发明人：BONOMO LUCIA; JACOBY DENIS; ARBICHA PASCAL; FONTENY FABIEN; KELLER FABRICE
权利人:FIRMENICH & CIE
摘要:The present invention relates to the field of organic synthesis and more specifically it concerns a process for the rearrangement of epoxides into allylic alcohols in a presence of zinc catalyst and two amino phenol.

专利号:US-7794761-B2
优先权日:2000-04-13
标 题:Methods for inducing anti-anxiety and calming effects in animals and humans
发明人：SHELBY NANCY J; GODFREY MITCHELL T; ROSENFELD MARK J
权利人:SEROCTIN RES & TECHNOLOGY INC
摘要:Phenolic compounds with a phenolic molecule to which are covalently linked an oxygen-containing group, a nitrogen or another oxygen containing group, and a C 1 -C 4 alkoxy group, or their precursor compounds, obtainable from monocotyledonous plants, or by chemical synthesis, have been found to calm and/or reduce anxiety and related behaviors and states in humans and animals. Additional chemical compounds of the present invention may include benzoxazinoids-cyclic hydroxyamic acids, lactams, and corresponding glucosides, which may serve as precursors to phenolic compounds. The phenolic compounds and precursors of phenolic compounds of the present invention, at concentrations suitable for human and animal therapeutic use, may be obtained from monocotyledonous plants such as corn in their early growth states which are timely harvested for optimum yield.

专利号:RU-2130020-C1
优先权日:1993-03-08
标 题 :Derivatives of benzoxazine, methods of their synthesis, a pharmaceutical preparation

专利号:WO-2024126769-A1
优先权日:2022-12-15
标题 :Process for preparing alpha,beta-unsaturated carbonyl compound
发明人：BONOMO LUCIA; JACOBY DENIS; FONTENY FABIEN; KELLER FABRICE
权利人:FIRMENICH & CIE
摘要:The present invention relates to the field of organic synthesis and more specifically it concerns a process for the oxidation of an allylic alcohol into an alpha,beta-unsaturated carbonyl compound in a presence of zirconium catalyst and a hydrogen acceptor.

专利号:CN-119241459-A
优先权日:2024-09-03
标题:Benzo (A) benzo (B) benzo (A oxazole/benzo Synthesis method of thiazole compound