CAS: 18751-99-0; (3S)-4T-[(R)-4,5-Dihydroxy-9-Methyl-3-Oxo-1,3-Dihydro-Naphtho[2,3-C]Furan-1-yl)-3R-Dimethylamino-2,5ξ-Dihydroxy-6-Oxo-Cyclohex-1-Enecarboxylic Acid Amide
该化合物是四环乙烷的衍生物,是一种广泛频谱抗生素,该化合物具有四环乙烷的典型特征,包括复杂的多环结构,有助于其生物活动,众所周知,它有能力通过与30S 脊髓炎亚单位结合,抑制细菌蛋白合成,从而防止 mRNA的转化. -环氧环曲,经常研究其潜在的治疗用途,特别是在治疗易感染细菌造成的感染方面. 此外,它可能具有防炎和抗癌特性,使其成为药物研究的主体,该化合物的特点是其溶性在有机溶剂中,水溶性有限,这可能影响其生物利用率和药用. 与其他四环乙烷衍生物一样,在评估临床环境中使用时,必须考虑其稳定性,潜在副作用以及与其他药物的相互作用.
- 英文名称(3S)-4T-[(R)-4,5-Dihydroxy-9-Methyl-3-Oxo-1,3-Dihydro-Naphtho[2,3-C]Furan-1-yl)-3R-Dimethylamino-2,5ξ-Dihydroxy-6-Oxo-Cyclohex-1-Enecarboxylic Acid Amide
- 中文名称β-Apo-土霉素
- IUPAC名称(3S,4S,5R)-4-[(3R)-1,3-dihydro-4,5-dihydroxy-9-methyl-3-oxonaphtho[2,3-c]furan-1-yl]-3-(dimethylamino)-2,5-dihydroxy-6-oxo-1-cyclohexene-1-carboxamide
- 其它别名BETA-APO-OXYTETRACYCLINE; ALPHA-APO-OXYTETRACYCLINE; beta-Apo-oxytetracycline, 'can be used as secondary standard'; β-Apo-oxytetracycline
- CAS编号18751-99-0
- MFCD编号:MFCD00062827
- FDA UNII编号:7HSY5812F9
- 分子式:C22H22N2O8分子量:442.42
- 产品CID: 953500
- 产品分类原料药 → 抗生素类药物 → 四环素类药
物理性质
MSDS等安全信息
上下游产品
hydrogenchloride Oxytetracycline H-naphtho[2,3-c]furan-1-one8,9-dihydroxy-4-methyl-3-(2,3,5-trihydroxy-phenyl)-3H-naphtho[2,3-c]furan-1-one合成工艺路线路线简述
📜土霉素置于盐酸体系中,用 水 用作溶剂,化学反应 2.0H,以23.2%的收率获得alpha-载脂蛋白-土霉素
参考文献:Viridicatumtoxins: Expanding On A Rare Tetracycline Antibiotic Scaffold
标题:Viridicatumtoxins: Expanding On A Rare Tetracycline Antibiotic Scaffold
摘要:Viridicatumtoxins,Which Belong To A Rare Class Of Fungal Tetracycline-Like Mycotoxins,Were Subjected To Comprehensive Spectroscopic And Chemical Analysis,Leading To Reassignment/assignment Of Absolute Configurations And Characterization Of A Remarkably Acid-Stable Antibiotic Scaffold. Structure Activity Relationship Studies Revealed Exceptional Growth Inhibitory Activity Against Vancomycin-Resistant Entercocci (Ic50 40 Nm),>270-Fold More Potent Than The Commercial Antibiotic Oxytetracycline.
Doi:10.1021/acs.Joc.5B02367
海关参考信息
- 2901210000-乙烯
2901220000-丙烯
2902600000-乙苯
2902902000-精萘 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
1. Lykkberg, A.K., Halling-Sørensen, B., Cornett, C., et al. Quantitative analysis of oxytetracycline and its impurities by LC-MS-MS. J. Pharm. Biomed. Anal. 34(2), 325-332 (2004). 2. Halling-Sørensen, B., Sengeløv, G., and Tjørnelund, J. Toxicity of tetracyclines and tetracycline degradation products to environmentally relevant bacteria, including selected tetracycline-resistant bacteria. Arch. Environ. Contam. Toxicol. 42(3), 263-271 (2002). 3. Hue, N.V., Toan, N.V., Long, L.T., et al. Preliminary studies on the toxic effects of degradation products of oxytetracycline and chlortetracycline on rats. J. Ag. Sci. Technol. A. B. 5, 469-474 (2015).合成参考文献
摘要:S109 | PARCEDC | List of 7074 potential endocrine disrupting compounds (EDCs) by PARC T4.2 | DOI:10.5281/zenodo.10944198
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