CAS: 15136-32-0; Methyl (Tert-Butoxycarbonyl)-L-Leucyl-D-Phenylalaninate

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N-tert-butoxycarbonyl-L-leucineN-tert-butoxycarbonyl-L-leucine D-phenylalanine methyl ester D-phenylalanine methyl ester hydr°Chloride methyl (2S)-2-amino-3-phenylpropanoateL-Leu-D-Phe-OMe (R)-2-[(S)-2-((S)-2-Amino-3-methyl-butyrylamino)-4-methyl-pentanoylamino]-3-phenyl-propionic acid methyl ester (R)-2-[(S)-2-((S)-2-tert-Butoxycarbonylamino-3-methyl-butyrylamino)-4-methyl-pentanoylamino]-3-phenyl-propionic acid methyl ester 2-[2-(2-{2-[(2-amino-4-methyl-pentanoyl)-methyl-amino]-4-methyl-pentanoylamino}-3-methyl-butyrylamino)-4-methyl-pentanoylamino]-3-phenyl-propionic acid

📜L-亮氨酸置于4-二甲氨基吡啶,1-羟基苯并三唑,盐酸-N-乙基-N'-(3-二甲氨基丙基)碳二亚胺,三乙胺,Sodium Hydroxide体系中,用 甲醇,二氯甲烷 用作溶剂,化学反应 13.0H,反应生成N-叔丁氧羰基-L-亮氨酰基-L-苯丙氨酸甲酯
参考文献:Synthesis Of A Novel Series Of L-Isoserine Derivatives As Aminopeptidase N Inhibitors
标题:Synthesis Of A Novel Series Of L-Isoserine Derivatives As Aminopeptidase N Inhibitors
摘要:A Series Of Novel L-Isoserine Derivatives Were Synthesised And Evaluated For Their Ability To Inhibit Aminopeptidase N (Apn)/cd13. In Our Preliminary Biological Results,Some Of These Compounds Possessed A Potent Inhibitory Activity Against The Apn. Within This Series,Compound 14B Not Only Showed Similar Enzyme Inhibition (Ic50 Of 12.2 Mu M) Compared With The Positive Control Bestatin (Half Maximal Inhibitory Concentration (Ic50) Of 7.3 Mu M),But Also Had A Potent Antiproliferative Activity Against Human Cancer Cell Lines Cells.
Doi:10.3109/14756361003698147