专利号:WO-2022256358-A1 优先权日:2021-06-03 标题 :Process for preparing medicaments 发明人:STUMPF ANDREAS; LAO DAVID; ANGELAUD REMY; MARX ANDREAS 权利人:GENENTECH INC; HOFFMANN LA ROCHE; HOFFMANN LA ROCHE 摘要:The present application affords an improved preparation of 3-(5-chloro-2-(difluoromethoxy)phenyl)-1H-pyrazol-4-amine hydrochloride qhich was a useful intermediate in the synthesis of JAK inhibitors.
专利号:US-6737434-B2 优先权日:2000-09-22 标 题 :Imidazole derivatives or their salts 发明人:TOKIZAWA MINORU; TAKEDA SUNAO; KANEKO YASUSHI; KUSANO KOJI; ETO HIROMICHI; TACHIBANA KOICHI; SATO SUSUMU; TANIYAMA TADAYOSHI 权利人:SSP CO LTD 摘要:Imidazole derivatives of the formula (1) or salts thereof, pharmaceuticals containing the derivatives or the salts, and intermediates for the synthesis of the derivatives or the salts (wherein R 1 is lower alkyl; R 2 is alkyl or aralkyl; and X 1 is halogeno). These compounds exhibit G-CSF-like activities and can be substituted for G-CSF preparations.
专利号:CN-114751870-B 优先权日:2022-02-28 标题 :A kind of 2-(isoxazol-5-yl)phenyl-3,4-dihydroxybenzoate and its derivatives and synthesis methods and applications
专利号:US-2011237659-A1 优先权日:2008-11-17 标题:Chromenone derivatives as trpv3 antagonists 发明人:CHAUDHARI SACHIN SUNDARLAL; THOMAS ABRAHAM; KADAM ASHOK BHAUSAHEB; DHONE SACHIN VASANTRAO; ADIK BHARAT GANGADHAR; KHAIRATKAR-JOSHI NEELIMA; KATTIGE VIDYA GANAPATI 权利人:GLENMARK PHARMACEUTICALS SA 摘要:The present invention provides transient receptor potential vanilloid (TRPV) modulators of formula (I). In particular, compounds described herein are useful for treating or preventing diseases, conditions and/or disorders modulated by TRPV3. Also provided herein are processes for preparing compounds described herein, intermediates used in their synthesis, pharmaceutical compositions thereof, and methods for treating or preventing diseases, conditions and/or disorders modulated by TRPV3.
专利号:CN-104086343-A 优先权日:2014-07-07 标题:A kind of catalytic synthesis method of diphenyl ether compounds
专利号:CN-114539042-A 优先权日:2022-02-23 标 题 :A new synthesis process of 5-fluoro-2-hydroxyacetophenone
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合成参考文献
摘要:Dong, X.; Liu , H., Science of Synthesis Knowledge Updates, (2019) 3, . 摘要:Dong, X.; Liu , H., Science of Synthesis Knowledge Updates, (2019) 3, . 摘要:Stanforth, S. P., Science of Synthesis Knowledge Updates, (2015) 1, 207. 摘要:González-Bello, C., Science of Synthesis Knowledge Updates, (2018) 1, 245. 摘要:Stanforth, S. P., Science of Synthesis Knowledge Updates, (2015) 1, 175.