CAS: 121147-94-2; 1-(Tert-Butyl) 2-Methyl (2S,4S)-4-(Benzoyloxy)Pyrrolidine-1,2-Dicarboxylate

英文名称1-(Tert-Butyl) 2-Methyl (2S,4S)-4-(Benzoyloxy)Pyrrolidine-1,2-Dicarboxylate
中文名称1-(叔丁基)2-甲基(2S,4S)-4-(苯甲酰氧基)吡咯烷-1,2-二羧酸酯
IUPAC名称1-(tert-butyl) 2-methyl (2S,4S)-4-(benzoyloxy)pyrrolidine-1,2-dicarboxylate
其它别名(2S,4S)-1-Tert-Butyl 2-Methyl 4-(Benzoylo×y)Pyrrolidine-1,2-Dicarbo×ylate; (2S,4S)-1-Tert-Butyl 2-Methyl 4-(Benzoyloxy)Pyrrolidine-1,2-Dicarboxylate; 1,2-Pyrrolidinedicarboxylic Acid, 4-(Benzoyloxy)-, 1-(1,1-Dimethylethyl) 2-Methyl Ester, (2S,4S)-; (2S,4S)-1-Tert-Butyl 2-Methyl 4-(Benzoylo×y)Pyrrolidine-1,2-Dicarbo×ylate Usp/ep/bp; 1-(Tert-Butyl) 2-Methyl (2S,4S)-4-(Benzoyloxy)Pyrrolidine-1,2-Dicarboxylate
CAS编号121147-94-2
MFCD编号:MFCD22421642
分子式:C18H23NO6分子量:349.38
产品CID: 283642
产品分类有机原料→分子砌块→芳环类化合物→苯类化合物

相似结构搜索
InChIKey: HCMBKFLKTBCNNU-KBPBESRZSA-N
InChI=1S/C18H23NO6/c1-18(2,3)25-17(22)19-11-13(10-14(19)16(21)23-4)24-15(20)12-8-6-5-7-9-12/h5-9,13-14H,10-11H2,1-4H3/t13-,14-/m0/s1
计算化学: 氢键受体数6.0氢键供体数*可旋转键数3.0

相似化合物

102195-79-9 114676-69-6 13726-69-7

MSDS等安全信息

上下游产品

1-tert-butyl 2-methyl (2S,4R)-4-hydroxy-1,2-pyrrolidinedicarboxylate benzoic acid sodium benzoate (2S,4R)-4-(methylsulfonyloxy)pyrrolidine-1,2-dicarboxylic acid 1-tert-butylester-2-methylester (2S,4S)-tert-butyl 4-hydroxy-2-(hydroxymethyl)pyrrolidine-1-carboxylate (2S,4S)-N-tert-butoxycarbonyl-4-hydroxyproline methyl ester 1-(1,1-dimethylethyl) 2-methyl (2S,4R)-4-amino-1,2-pyrrolidinedicarboxylate 1-tert-butyl 2-methyl (2S,4R)-4-azido-1,2-pyrrolidinedicarboxylate

合成工艺路线路线简述

合成目标产物 (2S,4S)-1-Tert-Butyl 2-Methyl 4-(Benzoyloxy)Pyrrolidine-1,2-Dicarboxylate 主要起始原料 Sodium Benzoate And (2S, 4R)-Boc-Gamma-Mso-Proline Methyl Ester
(文献来源)合成步骤主要原料 Sodium Benzoate 和 (2S, 4R)-Boc-Gamma-Mso-Proline Methyl Ester

📜N-Boc-反式-4-羟基-L-脯氨酸甲酯置于三乙胺体系中,用二氯甲烷,二甲基亚砜用作溶剂,化学反应 3.0H,反应生成(2S,4R)-Boc-4-苯甲酰氧基脯氨酸甲酯
参考文献:Synthesis And Biological Activity Of 1-Phenylsulfonyl-4-Phenylsulfonylaminopyrrolidine Derivatives As Thromboxane A 2 Receptor Antagonists
标题:Synthesis And Biological Activity Of 1-Phenylsulfonyl-4-Phenylsulfonylaminopyrrolidine Derivatives As Thromboxane A 2 Receptor Antagonists
摘要:The Synthesis And Biological Activity Of Novel 1-Phenylsulfonyl-4-Phenylsulfonylaminopyrrolidine Analogues Are Described. All Compounds Were Produced Through Modification Of The Substituent Formally Corresponding To The 1,3-Dioxane Ring System And The Omega-octenol Side Chain Of Thromboxane A(2) (Txa(2)),In Reference To The Structure Of Daltroban. Several Compounds Were Found To Be Potent Txa(2) Receptor Antagonists. Compound 51A Was The Most Effective Inhibitor Of 9.11-Epoxymethano Pgh(2) (U-46619)-Induced Rat Aortic Strip Contraction (Ic50 = 0.48 Nm). (C) 2002 Elsevier Science Ltd. All Rights Reserved.
Doi:10.1016/s0968-0896(01)00397-2