CAS: 1150271-74-1; 2-(4-(Bromomethyl)-3-Fluorophenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane
- 英文名称2-(4-(Bromomethyl)-3-Fluorophenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane
- 中文名称N-(4,4,5,5-四甲基-1,3,2-二氧苯甲醛-2-基)苄基)乙酰胺
- IUPAC名称2-(4-(bromomethyl)-3-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
- 其它别名4-(溴甲基)-3-氟苯硼酸频哪醇酯; 4-Bromomethyl-3-Fluorophenylboronic Acid,Pinacol
- CAS编号1150271-74-1
- MFCD编号:MFCD11855987
- 分子式:C13H17BBrFO2分子量:314.99
- 产品CID: 184472
- 产品分类有机原料→分子砌块→芳环类化合物→苯类化合物
相似化合物
903895-56-7 1029439-49-3 1310949-75-7MSDS等安全信息
上下游产品
CAS号903895-56-7 3-氟-4-甲基苯硼酸频那醇酯...合成工艺路线路线简述
- 合成目标产物 4-Bromomethyl-3-Fluorophenylboronic Acid,Pinacol 主要起始原料 2-(3-Fluoro-4-Methylphenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane
- (文献来源)合成步骤主要原料 2-(3-Fluoro-4-Methylphenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane
📜3-氟-4-甲基苯硼酸频那醇酯置于n-溴代丁二酰亚胺(Nbs),偶氮二异丁腈体系中,用 乙腈 用作溶剂,化学反应 4.0H,以76%的收率获得4-溴甲基-3-氟苯硼酸频那醇酯
参考文献:使用双功能接头进行click和suzuki偶联反应的模块化催化合成方法
标题:使用双功能接头进行click和suzuki偶联反应的模块化催化合成方法
摘要:稳定的苄基叠氮基硼酸酯1作为双功能接头的一个例子,允许在温和条件下将合成有价值的硼酸酯基序点击到其他分子上.叠氮基硼酸酯基序作为模块化构件的实用性已在使用顺序催化叠氮化物-炔烃环加成反应和suzuki偶联反应的药物样结构快速合成中得到证明.
Doi:10.1016/j.Tetlet.2010.05.104
海关参考信息
- 2902300000-甲苯
2905122000-异丙醇
2905143000-叔丁醇
2905310000-1,2-乙二醇 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-9012445-B2
优先权日:2012-01-12
标题 :Substituted 4-(1H-pyrazol-4-yl)benzyl analogues as positive allosteric modulators of mAChR M1 receptors
发明人：LINDSLEY CRAIG W; CONN P JEFFREY; WOOD MICHAEL R; MELANCON BRUCE J; POSLUSNEY MICHAEL S; TARR JAMES C
权利人:UNIV VANDERBILT
摘要:In one aspect, the invention relates to substituted 4-(1H-pyrazol-4-yl)benzyl analogs compounds, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the muscarinic acetylcholine receptor M 1 (mAChR M 1 ); synthesis methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
