📜3-氨基-2-噻吩甲酸甲酯置于palladium 10% On Activated Carbon 氢气,碳酸氢钠,N,N-二异丙基乙胺,三氯氧磷体系中,用 乙醇,乙酸乙酯 用作溶剂,化学反应 9.0H,反应生成2-氯噻吩并[3,2-D]嘧啶 参考文献: Compounds That Modulate Egfr Activity And Methods For Treating Or Preventing Conditions Therewith[fr] Composés Qui Modulent L'Activité Egfr Et Des Procédés Pour Traiter Ou Prévenir Des Affections Avec Ceux-Ci 标题: Compounds That Modulate Egfr Activity And Methods For Treating Or Preventing Conditions Therewith[fr] Composés Qui Modulent L'Activité Egfr Et Des Procédés Pour Traiter Ou Prévenir Des Affections Avec Ceux-Ci 摘要:提供了用于治疗或预防激酶介导的疾病的化合物和方法.
专利信息
专利号:US-9895374-B2 优先权日:2015-03-02 标 题:Thieno- and pyrrolopyrimidine analogues as anticancer agents and methods of use thereof 发明人:RADTKE KATHERINE L; TEMBURNIKAR KARTIK 权利人:UNIV MARYLAND 摘要:The present invention provides for the design and synthesis of halogenated thieno- and pyrrolopyrimidine compounds that exhibit cancer proliferation inhibitory activity and the use thereof for cancer treatment.
专利号:US-7030240-B2 优先权日:2003-03-31 标 题:Piperidinylamino-thieno[2,3-d] pyrimidine compounds 发明人:DHANOA DALE S; BECKER OREN; NOIMAN SILVIA; REDDY SEKAR A; CHERUKU SRINIVASA RAO; MELE NDEZ ROSA E; SHARADENDU ANURAG; CHEN DONGLI; MARANTZ YAEL; SHACHEM SHARON; HEIFETZ ALEXANDER; INBAL BOAZ; KESAVAN VENKITASAMY; BAR-HAIM SHAY 权利人:PREDIX PHARMACEUTICALS HOLDING 摘要:The invention relates to 5-HT receptor antagonists. Novel piperidinylamino-thieno[2,3-d] pyrimidine compounds represented by Formula I, and synthesis and uses thereof for treating diseases mediated directly or indirectly by 5-HT receptors, are disclosed. Such conditions include central nervous system disorders such as anxiety, depression, schizophrenia, neural injury, stroke, and migraine. Methods of preparation and novel intermediates and pharmaceutical salts thereof are also included.