CAS: 1119280-68-0; 2-Chlorothieno[3,2-D]Pyrimidine

该化合物是一种环状系统,包括硫诺和火利米地的结合环的杂交化合物,该化合物在硫诺环的第二个位置上具有氯替代成分,可影响其活性和生物活动;硫磺原子存在于硫酸环内,有助于其独特的电子特性,使其有可能成为各种药用化学和材料科学应用的候选物;通常,该类化合物具有有趣的药理特性,包括抗微生物和抗癌活动;分子结构允许与生物目标进行可能的相互作用,可以在药物开发中加以探讨;此外,该化合物的溶性与稳定性可能因亚种和环境而不同,影响其在各种化学反应和配方中的用途.

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相似化合物

1152475-42-7 16234-14-3 41102-26-5

欧盟法规

C&L通报

上下游产品

2,4-二氯噻吩并[3,2-D]嘧啶 2,4-Dichlorothieno[3,2-D]Pyrimidine 16234-14-3

合成工艺路线路线简述

    📜3-氨基-2-噻吩甲酸甲酯置于palladium 10% On Activated Carbon 氢气,碳酸氢钠,N,N-二异丙基乙胺,三氯氧磷体系中,用 乙醇,乙酸乙酯 用作溶剂,化学反应 9.0H,反应生成2-氯噻吩并[3,2-D]嘧啶
    参考文献: Compounds That Modulate Egfr Activity And Methods For Treating Or Preventing Conditions Therewith[fr] Composés Qui Modulent L'Activité Egfr Et Des Procédés Pour Traiter Ou Prévenir Des Affections Avec Ceux-Ci
    标题: Compounds That Modulate Egfr Activity And Methods For Treating Or Preventing Conditions Therewith[fr] Composés Qui Modulent L'Activité Egfr Et Des Procédés Pour Traiter Ou Prévenir Des Affections Avec Ceux-Ci
    摘要:提供了用于治疗或预防激酶介导的疾病的化合物和方法.

    专利信息


    专利号:US-9895374-B2
    优先权日:2015-03-02
    标 题:Thieno- and pyrrolopyrimidine analogues as anticancer agents and methods of use thereof
    发明人:RADTKE KATHERINE L; TEMBURNIKAR KARTIK
    权利人:UNIV MARYLAND
    摘要:The present invention provides for the design and synthesis of halogenated thieno- and pyrrolopyrimidine compounds that exhibit cancer proliferation inhibitory activity and the use thereof for cancer treatment.

    专利号:US-7030240-B2
    优先权日:2003-03-31
    标 题:Piperidinylamino-thieno[2,3-d] pyrimidine compounds
    发明人:DHANOA DALE S; BECKER OREN; NOIMAN SILVIA; REDDY SEKAR A; CHERUKU SRINIVASA RAO; MELE NDEZ ROSA E; SHARADENDU ANURAG; CHEN DONGLI; MARANTZ YAEL; SHACHEM SHARON; HEIFETZ ALEXANDER; INBAL BOAZ; KESAVAN VENKITASAMY; BAR-HAIM SHAY
    权利人:PREDIX PHARMACEUTICALS HOLDING
    摘要:The invention relates to 5-HT receptor antagonists. Novel piperidinylamino-thieno[2,3-d] pyrimidine compounds represented by Formula I, and synthesis and uses thereof for treating diseases mediated directly or indirectly by 5-HT receptors, are disclosed. Such conditions include central nervous system disorders such as anxiety, depression, schizophrenia, neural injury, stroke, and migraine. Methods of preparation and novel intermediates and pharmaceutical salts thereof are also included.

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    品牌试剂参考报价(招募中)

    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    合成参考文献


    参考文献:10.1023/b:rucb.0000035630.75564.2b
    摘要:Litvinov VP. Thienopyrimidines: synthesis, properties, and biological activity. Russian Chemical Bulletin. 2004 Mar;53(3):487–516. doi: 10.1023/b:rucb.0000035630.75564.2b.
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