CAS: 1043-21-6; 1-Hydroxy-5-Oxo-5H-Pyrido[3,2-A]Phenoxazine-3-Carboxylic Acid

该化合物是一种肾上衍生物,主要用于眼科学,主要用于抑制白内障形成,其作用是用铬化钙离子和抑制透镜氧化过程,从而减缓透镜蛋白的聚合,该化合物在瞄准透镜观察方面具有稳定性和特殊性,其机制包括干扰有助于白内障发育的quinone-potein 脉冲.Pirenoxine通常被作为一种眼科溶液,确保直接送到受影响地区.它通过延迟白内障进化过程的功效,加上良好的安全配置,使它在预防眼科护理中成为一个显著的选择.

结构式图片

物理性质

MSDS等安全信息

欧盟法规

ECHA物质C&L通报REACH预注册

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    专利信息


    专利号:US-9441053-B2
    优先权日:2013-07-11
    标 题 :Analytical method for detecting sulfated oligosaccharides
    发明人：WANG CHUNGYAO; HUANG IMIN; WU CHIAYEN; CHIANG YUNGTE; CHAO HELEN
    权利人:SCINOPHARM TAIWAN LTD
    摘要:The present invention describes an analytical method for detecting and quantitating poly-sulfated oligosaccharides, including Fondaparinux sodium, using hydrophilic interaction ultra-performance liquid chromatography (HILIC-UPLC) coupled with a charged aerosol detector (CAD) or a mass spectrometer (MS). This analytical method provides in-process control in a total synthesis of highly sulfated oligosaccharides by separation, quantification and mass identification. Systems and conditions utilizing such methods are also provided.

    专利号:CN-105503585-A
    优先权日:2015-12-23
    标题 :Synthesis method of 1,2,4-triacetoxybenzene serving as catalin drug intermediate

    专利号:WO-2011121404-A1
    优先权日:2010-03-29
    标 题 :Single-layer organometallic polymers, and method of synthesis

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    主要参考文献


    1: Upaphong P, Thonusin C, Choovuthayakorn J, Chattipakorn N, Chattipakorn SC. The Possible Positive Mechanisms of Pirenoxine in Cataract Formation. Int J Mol Sci. 2022 Aug 21;23(16):9431. doi: 10.3390/ijms23169431.
    2: Tang CF, Gao Y, Gulibairemu Y, Mao Y, Li YJ, Wang YD, Gu ZY. Anti-cataract effects of Dajizhi (Euphorbium) eye drops on selenite-induced cataracts in rat. J Tradit Chin Med. 2021 Oct;41(5):747-752. doi: 10.19852/j.cnki.jtcm.2021.05.009. 19(9):2050-2051. doi: 10.11124/JBIES-21-00318. 10(1):6757. doi: 10.1038/s41598-020-62436-7. Erratum for: Sci Rep. 2017 Jul 28;7(1):6819. doi: 10.1038/s41598-017-07208-6.
    5: Baig AM, Katyara P, Khaleeq A, Nazim F. Repurposing drugs: Ca2+ ion dependency that can be exploited to treat keratitis caused by Acanthamoeba castellanii. Eye (Lond). 2019 Nov;33(11):1823-1825. doi: 10.1038/s41433-019-0597-6. Epub 2019 Sep 25.

    合成参考文献


    参考文献:10.1007/bf02343075
    摘要:Saika S, Ooshima A, Yamanaka O, Okada Y, Tanaka S, Ohnishi Y. Effect of fibrostatin C, an inhibitor of prolyl 4-hydroxylase, on collagen secretion by human Tenon's capsule fibroblasts in vitro. Graefe's Archive for Clinical and Experimental Ophthalmology. 1996 Aug;234(Suppl 1):s214–22. doi: 10.1007/bf02343075.
    参考文献:10.1684/ejd.2015.2655
    摘要:Hashimoto T, Fukuda A, Himejima A, Morita S, Tsuruta D, Koga H, Krol RP, Ishii N. Ten cases of severe oral lichen planus showing granular C3 deposition in oral mucosal basement membrane zone. European Journal of Dermatology. 2015 Nov;25(6):539–47. doi: 10.1684/ejd.2015.2655.
    参考文献:10.1007/164_2016_90
    摘要:Crispim J, Chamon W. Lens: Management of Cataract Surgery, Cataract Prevention, and Floppy Iris Syndrome. Handb Exp Pharmacol. 2017;242():163–78. doi: 10.1007/164_2016_90.
    参考文献:10.1016/j.jphotobiol.2003.07.004
    摘要:Ciuffi M, Pisanello M, Pagliai G, Raimondi L, Franchi-Micheli S, Cantore M, Mazzetti L, Failli P. Antioxidant protection in cultured corneal cells and whole corneas submitted to UV-B exposure. Journal of Photochemistry and Photobiology B: Biology. 2003 Oct;71(1-3):59–68. doi: 10.1016/j.jphotobiol.2003.07.004.
    参考文献:10.1007/s10384-009-0754-8
    摘要:Yamazaki S, Nanno M, Kimura T, Suzumura H, Yoshikawa K. Effects of switching to SofZia-preserved travoprost in patients who presented with superficial punctate keratopathy while under treatment with latanoprost. Japanese Journal of Ophthalmology. 2010 Jan;54(1):7–14. doi: 10.1007/s10384-009-0754-8.
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