CAS: 88-96-0; Phthalamide

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CAS号91-15-6 邻苯二甲腈 | CAS号643-79-8 邻苯二甲醛 | CAS号5394-18-3 N-(4-溴丁基)邻苯二甲酰亚胺 | CAS号87789-49-9 5-氟-2-(1-哌嗪基)-嘧啶 | CAS号118-29-6 N-羟甲基邻苯二甲酰亚胺 | CAS号20877-81-0 5-甲基-2H-苯并[d][1... | CAS号60-29-7 乙醚 | CAS号91-15-6 邻苯二甲腈 | CAS号17174-98-0 2-氰基苯甲酰胺 | CAS号1971-49-9 N-乙酰邻苯二甲酰亚胺 | CAS号22641-00-5 3,4-dihydro-2H-... | CAS号86-96-4 2,4-喹唑啉二酮 | CAS号612-14-6 邻苯二甲醇 | CAS号14352-51-3 3-亚氨基异吲哚啉酮 | CAS号1541-26-0 2-(2-环己烯)异吲哚啉-1,3-二酮 | CAS号89130-76-7 3-(dimethylamin...

邻苯二甲醛置于[ru(η6-C6Me6)Cl2(Tris(Dimethylamino)Phosphine)],盐酸羟胺,碳酸氢钠体系中,用 水 作为反应溶剂,化学反应 24.0H,以59%的收率获得产物邻苯二酰胺
参考文献:钌在水中由钌催化一锅合成伯酰胺†
标题:钌在水中由钌催化一锅合成伯酰胺†
摘要:容易获得的芳烃-钌(II)配合物化合物[rucl 2(η 6-C 6我6){p(nme 2)3 }](5摩尔%)被证明是用于从伯酰胺的直接合成的有效的催化剂醛和盐酸羟胺(nH2Oh.hcl)在水在100oc下.该方法需要存在nahco 3来捕获在关键醛糖肟中间体形成过程中释放的hcl,该方法可同时与芳族,杂芳族,α,β-不饱和醛和脂肪醛同时使用,并能耐受多个官能团.使用可商购的nH2Oh溶液(50 Wt.%水).
DOI:10.1039/c3Ra23195J

专利信息

专利号:US-8138330-B2
优先权日:2006-09-11
标 题 :Process for the synthesis of oligonucleotides
发明人：LEUCK MICHAEL; WOLTER ANDREAS; STUMPE ALFRED
权利人:LEUCK MICHAEL; WOLTER ANDREAS; STUMPE ALFRED; SIGMA ALDRICH CO LLC
摘要:The present invention discloses novel methods for the synthesis of oligonucleotides with nucleoside phosphoramidites on solid supports. The methods comprise the stepwise chain assembly of oligonucleotides on supports with 5′-acyl phosphoramidites. The synthesis cycles consist of a front end deprotection step which is conducted with a solution of a primary amine or a phenolate, a phosphoramidite coupling step with a 5′-acyl nucleoside phosphoramidite in the presence of an activator, a phosphite oxidation step and an optional capping step. The novel methods improve the quality of synthetic oligonucleotides due to the irreversibility of the front end deprotection step, which prevents the formation of deletion sequences, and due to the avoidance of acidic reagents in the synthesis cycles, which prevent the formation of depurination side products. The invention further discloses novel nucleoside phosphoramidite compositions wherein the phosphoramidites carry acyl front end protective groups which are cleavable with primary amines or phenolates. The invention is applicable to the synthesis of oligodeoxyribonucleotides, oligoribonucleotides and oligonucleotides with modifications in their sugar or phosphate groups.

专利号:US-7943594-B2
优先权日:2002-07-10
标 题 :Solid-phase and solution-phase synthesis of glycosylphosphatidylinositol glycans
发明人：SEEBERGER PETER H; HEWITT MICHAEL C; SNYDER DANIEL A
权利人:MASSACHUSETTS INST TECHNOLOGY
摘要:One aspect of the present invention relates to solution-phase approaches to GPI synthesis. Another aspect of the present invention relates to key building blocks, and syntheses thereof, useful for GPI assembly. Yet another aspect of the invention relates to an automated method for the synthesis of GPIs and fragments thereof.

专利号:WO-9961509-B1
优先权日:1998-05-21
标题:Synthesis of semi-crystalline polyphthalamides through reactive extrusion of hexamethylene terephthalamide oligomer with lower melting, semi-crystalline or amorphous polyamides
发明人：LEBOEUF CHRISTIAN; HARBOURNE DAVID ALAN
权利人:LEBOEUF CHRISTIAN; HARBOURNE DAVID ALAN
摘要:This invention relates to the synthesis of semi-crystalline polyphthalamides (i.e. containing monomeric units of terephthalic acid and hexamethylene diamine) through reactive extrusion of hexamethylene terephthalamide oligomer, or the oligomer of another 6T-rich copolymer, with lower melting semi-crystalline or amorphous polyamides. This process is particularly useful since it is centered around the use of stirred autoclaves for the synthesis of the 6T oligomer and the semi-crystalline or amorphous polyamides which are subsequently combined in a twin screw extruder equipped for devolatilization of water of reaction. It can also be used for the modification of existing semi-crystalline or amorphous polyamides (not necessarily phthalamides) with low levels of 6T.

专利号:US-2024024489-A1
优先权日:2020-11-20
标 题:Protected disaccharides, their process of preparation and their use in the synthesis of zwitterionic oligosaccharides, and conjugates thereof
发明人：MULARD LAURENCE; DHARA DEBASHIS; PFISTER HELENE; PAOLETTI JULIE; PHALIPON ARMELLE; GUERREIRO-INVERNO CATHERINE
权利人:PASTEUR INSTITUT
摘要:The present invention provides zwitterionic oligosaccharides, in particular fragments of the surface polysaccharides from Shigella sonnei and Shigella sonnei conjugates comprising them. The present invention also provides protected disaccharides, their process of preparation and their use in the synthesis of zwitterionic oligosaccharides, and conjugates thereof, the disaccharide repeating unit of Shigella sonnei being: (I)

专利号:EP-2586773-A1
优先权日:2011-10-27
标题 :Synthesis of Triazolopyrimidine Compounds
权利人:LEK PHARMACEUTICALS
摘要:The present invention relates to the field of organic synthesis and describes the synthesis of specific triazolopyrimidine compounds and intermediates thereof as well as related derivatives.

专利号:US-7491520-B2
优先权日:2004-01-19
标题 :Biochemical synthesis of 6-amino caproic acid
发明人：RAEMAKERS-FRANKEN PETRONELLA C; NOSSIN PETRUS M M; BRANDTS PAUL M; WUBBOLTS MARCEL G; PEETERS WIJNAND P H; ERNSTE SANDRA; WILDEMAN DE STEFAAN M A; SCHUERMANN MARTIN
权利人:DSM IP ASSETS BV
摘要:The invention relates to biochemical synthesis of 6-amino caproic acid from 6-aminohex-2-enoic acid compound or from 6-amino-2-hydroxyhexanoic acid, by treatment with an enzyme having α,β-enoate reductase activity towards molecules containing an α,β-enoate group and a primary amino group. The invention also relates to processes for obtaining suitable genetically engineered cells for being used in such biotransformation process, and to precursor fermentation of 6-amino caproic acid from intermediates leading to 6-amino caproic acid. Finally, the invention relates to certain novel biochemically produced compounds, namely 6-aminohex-2-enoic acid, 6-aminohexanoic acid, as well as to caprolactam produced therefrom and to nylon-6 and other derivatives produced from such biochemically produced compounds or caprolactam.