CAS: 848-21-5; 17-Hydroxy-19-Nor-17Alpha-Pregna-4,9,11-Trien-20-Yn-3-One

📜哌啶,N,N-二甲基甲酰胺,,,1-(9-芴基甲基)哌啶,乙醇置于氩体系中,化学反应 0.83H,以gave A301=0.0785的收率获得产物三烯炔诺酮
参考文献:Interleukin-1 Receptor Antagonists,Compositions,And Methods Of Treatment
标题:Interleukin-1 Receptor Antagonists,Compositions,And Methods Of Treatment
摘要:本发明揭示了设计用于抑制il-1R类型1受体的生物活性并抑制il-1R/il-1Racp相关细胞信号和生物活性的肽.包含本发明的il-1R拮抗剂的组合物在治疗与il-1相关的疾病或病况,如关节炎,类风湿性关节炎,骨关节炎和炎症性肠病以及其他慢性或急性炎症性疾病方面是有用的.本发明还揭示了一种具有il-1R拮抗剂活性的分离化合物,所述化合物选自以下组:包含氨基酸序列rytpelx的肽,其中r,Y,T,P,E,L分别指它们对应的氨基酸,X选自无氨基酸和丙氨酸(a);及其衍生物,其中衍生物在肽的rytpel部分中包含一种,两种或三种氨基酸修饰,所述修饰选自氨基酸添加,删除或替换,并且所述衍生物保持其拮抗剂il-1R活性.

专利信息

专利号:US-11472916-B2
优先权日:2018-01-17
标题:Flow controlled synthesis of bottlebrush macromolecules
发明人：GUIRONNET DAMIEN S; WALSH DYLAN J
权利人:UNIV ILLINOIS
摘要:Shape, size and composition are nature's most fundamental design features, enabling highly complex functionalities. Despite recent advances, the independent control of shape, size and chemistry of macromolecules remains a synthetic challenge. Herein reported is a scalable methodology to produce large well-defined macromolecules with programmable shape, size and chemistry that combines reactor engineering principles and controlled polymerizations. Specifically, bottlebrush polymers with conical, ellipsoidal and concave architectures are synthesized using two orthogonal polymerizations. The chemical versatility is highlighted by the synthesis of a compositional asymmetric cone. The strong agreement between predictions and experiments validate the precision that this methodology offers.

专利号:US-2025281509-A1
优先权日:2021-04-26
标 题 :Sequential hormone therapy to improve survival and enhance response to immune therapy in men with prostate cancer
发明人：DENMEADE SAMUEL R; ISAACS JOHN T; ANTONARAKIS EMMANUEL S; KACHHAP SUSHANT; MARKOWSKI MARK CHRISTOPHER
权利人:UNIV JOHNS HOPKINS
摘要:Disclosed are methods for treating men with castrate resistant prostate cancer with a sufficient dose of testosterone to achieve supraphysiologic serum levels of testosterone in sequence with androgen ablative treatment or androgen synthesis inhibitors for one or more cycles until evidence of radiographic progression, at which point the subject will receive immune checkpoint blockade therapy.

专利号:US-2002159954-A1
优先权日:2000-12-01
标题:Aerodynamically light vaccine for active pulmonary immunization
发明人：SMALL PARKER; BENDER BRADLEY S
摘要:Improved aerodynamically light particles for vaccine delivery to the pulmonary system, and methods for their synthesis and administration are provided. In a preferred embodiment, the aerodynamically light vaccine:) are made of a biodegradable material and have a tap density less than 0.4 g/ml and a mass mean diameter between 5 μm and 30 μm. The particles may be formed of biodegradable materials such as biodegradable polymers. For example, the particles may be formed of a functionalized polyester graft copolymer consisting of a linear .alpha.-hydroxy-acid polyester backbone having at least one amino acid group incorporated therein and it least one poly(amino acid) side chain extending from an amino acid group in the polyester backbone. In one embodiment, aerodynamically light vaccine particles having a large mean diameter, for example greater than 5 μm, can be used for enhanced delivery of a vaccine agent to the alveolar region of the lung. The aerodynamically light vaccine particles incorporating an immunizing agent may be effectively aerosolized for administration to the respiratory tract to permit systemic or local delivery of wide variety of immunizing agents.