CAS: 759-73-9; 1-Ethyl-1-Nitrosourea

📜Cytochrome鎐frompigeonbreastmuscle置于硫酸,Sodium Nitrite体系中,化学反应生成 N-亚硝基-N-乙基脲
参考文献:六元磺胺类药物与重氮甲烷的无金属扩环反应:七元烯磺酰胺的一种方法
标题:六元磺胺类药物与重氮甲烷的无金属扩环反应:七元烯磺酰胺的一种方法
摘要:已开发了由n-甲苯磺酰hydr原位反应生成的六元n-磺酰亚胺碱与不稳定的重氮甲烷的新的无金属环扩环反应.该反应通过tiffeneau-demjanov重排和分子内质子转移互变异构过程提供了有价值的七元烯磺酰胺.而且,该扩环反应可以单锅方式进行,并通过使用芳基醛将其规模扩大至克级,而无需分离n-甲苯磺酰hydr.
DOI:10.1002/anie.201508804

专利信息

专利号:US-7087378-B1
优先权日:1996-02-26
标 题 :Design, synthesis and use of specific polyamide DNA-binding ligands
发明人：BAIRD ELDON E; DERVAN PETER B
权利人:CALIFORNIA INST OF TECHN
摘要:The invention encompasses improved selective polyamides for binding to specific nucleotide sequences of double stranded DNA as well as methods for designing and synthesizing polyamide DNA binding ligands that are selective for an identified specific nucleotide sequence. The 3-hydroxy-N-methylpyrrole/N-methylpyrrole carboxamide pair specifically recognizes the T•A base pair, while the N-methylpyrrole/3-hydroxy-N-methylpyrrole pair recognizes A•T nucleotide pairs. Similarly, an N-methylimidizole/N-methylpyrrole carboxamide pair specifically recognizes the G•C nucleotide pair, and the N-methylpyrrole/N-methylimidizole carboxamide pair recognizes the C•G nucleotide pair.

专利号:US-2023175002-A1
优先权日:2020-04-03
标题 :Suberin biosynthetic genes and regulators
发明人：BRADY SIOBHAN M; CANTO-PASTOR ALEX; GOURAN MONA; KAJALA KAISA; KAWA DOROTA; MASON GRACE ALEX; MANZANO CONCEPCION; NIRMAL NIBA; SHAAR-MOSHE LIDOR; BAILEY-SERRES JULIE; BOROWSKY ALEX; REYNOSO MAURICIO; SINHA NEELIMA
权利人:UNIV CALIFORNIA
摘要:The present disclosure provides a list of genes, and the proteins encoded by these genes, that modulate and/or participate in the synthesis of the biopolymer suberin. The genes described here are useful in methods for producing genetically modified plants or breeding plants with altered production (enhanced or disrupted) of suberin. Such plants can contain modified or mutated candidate peptides; or have disrupted expression of using methods such as clustered regularly-interspaced short palindromic repeats (CRISPR)/CRISPR associated (Cas) nuclease, an antisense nucleic acid, a zinc finger nuclease (ZFN), or a transcription activator-like effector (TALE) nuclease. Suberin has a positive influence on response to plant water stress, a long-lasting role as a carbon sink in soil; and the lack of suberin encourages symbioses for nutrient uptake as well as for prevention of pathogenicity.

专利号:US-2024093217-A1
优先权日:2022-08-12
标题:Rice suberin biosynthetic genes and regulators
发明人：BAILEY-SERRES JULIA; BOROWSKY ALEXANDER T; REYNOSO MAURICIO
权利人:UNIV CALIFORNIA
摘要:The present disclosure provides a list of genes, and the proteins encoded by these genes, that modulate and/or participate in the synthesis of the biopolymer suberin. The genes described here are useful in methods for producing genetically modified plants or breeding plants with increased or decreased suberin. Such plants can contain modified, mutated, or engineered candidate peptides; or have disrupted or enhanced expression using methods such as clustered regularly-interspaced short palindromic repeats (CRISPR)/CRISPR associated (Cas) nuclease, an antisense nucleic acid, a zinc finger nuclease (ZFN), or a transcription activator-like effector (TALE) nuclease. Increased suberin has a positive influence on response to plant water stress and pathogen protection, and a long-lasting role as a carbon sink in soil; and decreased suberin encourages symbioses and nutrient uptake.

专利号:WO-2009124694-A2
优先权日:2008-04-07
标 题 :Synthesis of polyunsaturated fatty acids in yeast

专利号:US-6673940-B1
优先权日:1999-01-08
标 题:Compositions and methods relating to cyclic compounds that undergo nucleotide base pair-specific interactions with double-stranded nucleic acids
发明人：DERVAN PETER B; BAIRD ELDON E
权利人:CALIFORNIA INST OF TECHN
摘要:The design, synthesis, and use of cyclic compounds, including cyclic polyamides, is described. Such compounds comprise at least two polymer portions, one of which comprises at least three molecular units, and the other comprises at least four molecular units. At least one molecular unit of such a compound is a hydrogen bond donor or acceptor. The polymer portions are covalently linked to form a cycle. These compounds are capable of targeting specific nucleotide sequences in double-stranded nucleic acids, particularly double-stranded DNA. Accordingly, such compounds can be used to modulate, e.g., increase or decrease, the expression of one or more genes in vitro or in vivo.

专利号:US-9593344-B2
优先权日:2014-07-03
标 题:Enhanced triacylglycerol accumulation in vegetative tissues of plants
发明人：XU CHANGCHENG; FAN JILIAN; YAN CHENGSHI; SHANKLIN JOHN
权利人:BROOKHAVEN SCIENCE ASS LLC
摘要:In the tgd1-1 mutant that displays substantially enhanced TAG synthesis and turnover, disruption of SUGAR-DEPENDENT1 (SDP1) TAG lipase or PEROXISOMAL TRANSPORTER1 (PXA1) severely decreases FA turnover, leading to an increase in leaf TAG content up to 9% of dry weight and total leaf lipid by three-fold. The membrane lipid content and composition of tgd1-1 sdp1-4 and tgd1-1 pxa1-2 double mutants are altered and they are compromised in growth and development and fertility.