CAS: 7538-44-5; 2,2'-((3-(Triethoxysilyl)Propyl)Azanediyl)Bis(Ethan-1-Ol)

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(3-chloropropyl)triethoxysilane 2,2'-iminobis[ethanol]

3-氯丙基三乙氧基硅烷,二乙醇胺置于potassium Iodide体系中,用 二甲基亚砜 作为反应溶剂,化学反应生成 3-[双(2-羟乙基)氨基]丙烷-三乙氧基硅烷 溶液
参考文献:基于化学键合的有机硅增韧异氰酸酯树脂的制备方法
标题:基于化学键合的有机硅增韧异氰酸酯树脂的制备方法
摘要:本发明公开了一种基于化学键合的有机硅增韧异氰酸酯树脂的制备方法,首先以二乙醇胺和3‑氯丙基三乙氧基硅烷为起始原料,在催化剂碘化钾的催化下,发生取代反应,制备得到了增韧改性剂m1,接着在四氯化锡的催化下,增韧改性剂m1上的羟基与六亚甲基二异氰酸酯上的‑ocn反应得到了改性六亚甲基二异氰酸酯树脂,然后其在水溶液中解离成式m3所示的硅醇氰酸酯,引入了羟基,最后将硅醇氰酸酯浸渍于十二烷基三乙氧基硅烷的乙醇溶液中,经羟基间的缩合反应,得到了机硅增韧异氰酸酯树脂;以化学键的方式引入了多种柔性官能团,这些柔韧官能基团可减少氰酸酯的内应力,阻止树脂基体断裂,进而达到增韧的目的.

专利信息

专利号:US-8008005-B2
优先权日:2001-05-18
标题 :Method for the synthesis of DNA sequences
发明人：BELSHAW PETER J; SUSSMAN MICHAEL J; CERRINA FRANCESCO; FLICKINGER SHANE T
权利人:WISCONSIN ALUMNI RES FOUND
摘要:A method is disclosed for the direct synthesis of double stranded DNA molecules of a variety of sizes and with any desired sequence. The DNA molecule to be synthesis is logically broken up into smaller overlapping DNA segments. A maskless microarray synthesizer is used to make a DNA microarray on a substrate in which each element or feature of the array is populated by DNA of a one of the overlapping DNA segments. The DNA segments are released from the substrate and held under conditions favoring hybridization of DNA, under which conditions the segments will spontaneously hybridize together to form the desired DNA construct. This method makes possible the remote assembly of DNA sequence, through a process analogous to facsimile transmission of documents, since the information on DNA to be made can be transmitted remotely to an instrument which can then synthesize any needed DNA sequence from the information.

专利号:US-5679773-A
优先权日:1995-01-17
标题 :Reagants and methods for immobilized polymer synthesis and display
发明人：HOLMES CHRISTOPHER P
权利人:AFFYMAX TECH NV
摘要:Compounds and methods for solid phase synthesis of organic molecules including peptides, oligonucleotides, benzodiazepines, beta -turn mimetics, and prostaglandins. The present invention provides new reagents in the form of linking groups and resins and substrates having attached linking groups which are useful in solid phase synthesis of high density arrays of organic molecules. The invention also provides methods which increase yields of various organic synthesis strategies.

专利号:US-2013165350-A1
优先权日:2011-12-22
标 题:Surface linkers for array synthesis
发明人：KUIMELIS ROBERT; MCGALL GLENN; PAO DEXTER; CHEN ZIHUI; AXELROD TREVOR
权利人:KUIMELIS ROBERT; MCGALL GLENN; PAO DEXTER; CHEN ZIHUI; AXELROD TREVOR; AFFYMETRIX INC
摘要:The present invention provide several methods of derivatizing a surface of a support with one or more linkers thus providing a suitable platform for synthesis of a polymer array, particular a nucleic acid array. Some methods derivatize a surface with a self-assembled monolayer (SAM) of a linker. The SAM confers advantages of hydrolytic stability, broad compatibility with synthesis and detection chemistries, and reduced emergence of latent functional groups during polymer array synthesis. Substrates can also be derivatized with multi-layers of SAMs providing greater hydrolytic stability. Substrates can also be derivatized by synthesizing a linker in situ on the substrate by atom transfer radical polymerization of functional and functional monomers. Appropriate selection of monomers reduces emergence of latent functional groups in subsequent array synthesis.

专利号:US-8859196-B2
优先权日:2002-06-20
标 题:Antireflective coatings for high-resolution photolithographic synthesis of DNA arrays
发明人：TRULSON MARK O; MCGALL GLENN H; SYWE BEI-SHEN; KAJISA LISA T; TRUONG DANA; RAVA RICHARD P; GOLDBERG MARTIN J
权利人:TRULSON MARK O; MCGALL GLENN H; SYWE BEI-SHEN; KAJISA LISA T; TRUONG DANA; RAVA RICHARD P; GOLDBERG MARTIN J; AFFYMETRIX INC
摘要:The present invention provides an array of polymers and methods of forming arrays of polymers by providing a substrate having a first layer including one or more dielectric coatings on a solid support and a second layer including a plurality of polymers disposed on the first layer. The invention also provides methods for forming an array of polymers on a substrate using light-directed synthesis by providing a substrate having a first layer including one or more dielectric coatings on a solid support, derivatizing the first layer by contacting the first layer with a silanation reagent, and a second layer disposed on said first layer wherein the second layer includes functional groups protected with a photolabile protecting group.

专利号:US-8637434-B2
优先权日:1996-04-17
标题 :System for photolithographic synthesis of polymer arrays
发明人：GOLDBERG MARTIN J; DIGGELMAN MARTIN; HUBBELL EARL A; MCGALL GLENN H; NAM NGO; MORRIS MACDONALD S; YAMAMOTO MELVIN; TAN JENNIFER; RAVA RICHARD
权利人:AFFYMETRIX INC
摘要:The present invention provides novel processes for the large scale preparation of arrays of polymer sequences wherein each array includes a plurality of different, positionally distinct polymer sequences having known monomer sequences. The methods of the invention combine high throughput process steps with high resolution photolithographic techniques in the manufacture of polymer arrays.

专利号:US-2006257560-A1
优先权日:2004-12-30
标 题 :Polymer surfaces for insitu synthesis of polymer arrays
发明人：BARONE ANTHONY D; LI HANDONG; MCGALL GLENN H
权利人:AFFYMETRIX INC
摘要:In one aspect of the present invention polymers are used to create films providing three-dimensional array substrates. The films were stable and presented good hydroxyl group numbers as compared with arrays without polymer films. It is an object of the present invention that three dimensional arrays substrates provide a means to obtain higher density polymer arrays.