CAS: 74663-96-0; 3-Methyl-Pyridine-4-Carbaldehyde

相似化合物

116985-92-3 58997-11-8 38070-73-4

上下游产品

CAS号72990-37-5 3-氯吡啶-4-甲醛 | CAS号823-96-1 三甲基环三硼氧烷 | CAS号583-58-4 3,4-二甲基吡啶 | CAS号251101-36-7 3-甲基吡啶-4-甲酰胺 | CAS号7584-05-6 3-甲基-4-氰基吡啶

3,4-二甲基吡啶置于copper(II) Choride Dihydrate,氧气体系中,用 二甲基亚砜 作为反应溶剂,化学反应 24.0H,以80%的收率获得产物3-甲基吡啶-4-甲醛
参考文献:突触密度正电子发射断层扫描成像剂 Synvest-1 的有机催化不对称合成
标题:突触密度正电子发射断层扫描成像剂 Synvest-1 的有机催化不对称合成
摘要:杂环非乙酰胺配体用作突触小泡糖蛋白 2A (Sv2A) 的正电子发射断层扫描 (Pet) 成像剂,在诊断各种神经精神疾病方面具有潜在应用.迄今为止,获取这些光学活性化合物的主要合成策略涉及后期中间体的外消旋合成,然后是对映体的分离.在这里,我们描述了使用亚胺有机催化不对称合成 Synvest-1,一种重要的 Sv2A Pet 显像剂.关键步骤涉及使用 Merck 双酸助催化剂系统在 Jørgensen-hayashi 催化剂存在下将硝基甲烷与肉桂醛共轭加成.所得内酰胺的n-烷基化随后完成了 Synvest-1 的七步合成.这种方法适用于有机锡类似物的合成,在铜 (II) 介导的氟脱锡之后,可以快速获得 [18 F]Synvest-1.
DOI:10.1021/acs.Joc.2C01895

专利信息

专利号:US-5521179-A
优先权日:1991-04-18
标题 :Heterocyclic amides
发明人：BERNSTEIN PETER R; SHAW ANDREW; THOMAS ROYSTON M; WARNER PETER; WOLANIN DONALD J
权利人:ZENECA LTD
摘要:The present invention relates to certain novel heterocyclic amides which are 1-pyridylacetamide compounds of formula I, set out herein, which are inhibitors of human leukocyte elastase (HLE), also known as human neutrophil elastase (HNE), making them useful whenever such inhibition is desired, such as for research tools in pharmacological, diagnostic and related studies and in the treatment of diseases in mammals in which HLE is implicated. The invention also includes intermediates useful in the synthesis of these heterocyclic amides, processes for preparing the heterocyclic amides, pharmaceutical compositions containing such heterocyclic amides and methods for their use.

专利号:WO-2015088564-A1
优先权日:2013-12-13
标 题:P2x4 receptor modulating compounds
发明人：NEWCOM JASON S; SPEAR KERRY L
权利人:SUNOVION PHARMACEUTICALS INC
摘要:Provided herein are P2X4 receptor modulating compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or management of various disorders, including but not limited to, chronic pain, neuropathy, inflammatory diseases and central nervous system disorders.