CAS: 65754-26-9; 1-Methyl-2-Nitro-4-(Trifluoromethyl)Benzene

上下游产品

CAS号6140-17-6 4-甲基三氟甲苯 | CAS号7664-93-9 硫酸 | CAS号81290-20-2 (三氟甲基)三甲基硅烷 | CAS号290825-52-4 2-(2-硝基-4-(三氟甲基... | CAS号25449-96-1 3-氨基-4-甲基三氟甲苯

📜4-甲基三氟甲苯置于硫酸,Potassium Nitrate体系中,化学反应 0.17H,反应生成 1-甲基-2-硝基-4-(三氟甲苯)甲苯
参考文献:连续多相流硝化和低温流甲酰化:实现医药中间体的工艺开发和制造
标题:连续多相流硝化和低温流甲酰化:实现医药中间体的工艺开发和制造
摘要:制造 Api 和医药中间体需要开发可扩展,安全且环保的工艺.具有高放热性或其他性质危险的反应,以及涉及形成不稳定中间体的反应,都可以从连续加工中受益.由于该技术在低反应体积下运行的固有能力,促进改进的温度控制和安全地适应更高的压力,该技术已被整个制药行业广泛采用.两个这样的工业相关例子是芳族硝化和区域选择性芳环金属化,然后用亲电子试剂捕获.在批处理中进行时,这两种反应类别通常都面临放大的挑战.硝化反应通常具有多相,与大量放热相关的混合敏感反应,可导致形成潜在危险的过硝化副产物.同样,芳环的金属化反应通常需要低温条件,难以大规模实现.在这项研究中,对混合限制的固-液-液 (S-L-L) 硝化反应进行了评估,以了解传输现象.hatta 数的确定和叶轮功率对动力学的影响使设计出安全,可扩展,高产且稳健的连续搅拌罐 (Cstr) 流动工艺成为可能.对关键甲酰化反应参数的研究导致了第一代管式流动反应器设计,可在中试工厂中处理
DOI:10.1021/acs.Oprd.1C00249

专利信息

专利号:WO-9948868-A9
优先权日:1998-03-26
标 题 :Heterocyclic classes of compounds for the modulating tyrosine protein kinase
发明人：FONG ANNIE; HANNAH ALISON; HARRIS G DAVIS; HIRTH PETER; HUBBARD STEVEN R; LANGECKER PETER; LIANG CONGXIN; MCMAHON GERALD; MOHAMMADI MOOSA; SCHLESSINGER JOSEPH; SHAWVER LAURA K; SUN LI; TANG PENG C; ULLRICH AXEL
权利人:SUGEN INC; UNIV NEW YORK; MAX PLANCK INST FUR BIOCHEMIE; FONG ANNIE; HANNAH ALISON; HARRIS G DAVIS; HIRTH PETER; HUBBARD STEVEN R; LANGECKER PETER; LIANG CONGXIN; MCMAHON GERALD; MOHAMMADI MOOSA; SCHLESSINGER JOSEPH; SHAWVER LAURA K; SUN LI; TANG PENG C; ULLRICH AXEL
摘要:The invention relates to certain indolinone-based and pyrazolylamide-based compounds, their method of synthesis, and combinatorial libraries consisting of the compounds. The invention also relates to methods of modulating the function of protein kinases using these compounds and methods of treating diseases by modulating the function of protein kinases and related signal transduction pathways.

专利号:US-6514981-B1
优先权日:1998-04-02
标题:Methods of modulating tyrosine protein kinase function with indolinone compounds
发明人：TANG PENG CHO; SUN LI
权利人:SUGEN INC
摘要:The invention relates to certain indolinone compounds, their method of synthesis, and a combinatorial library consisting of the indolinone compounds. The invention also relates to methods of modulating the function of protein tyrosine kinases using indolinone compounds and methods of treating diseases by modulating the function of protein tyrosine kinases and related signal transduction pathways.

专利号:CN-114907232-B
优先权日:2022-04-28
标题 :Synthesis process of 2-nitro-4-trifluoromethylbenzonitrile