CAS: 5560-72-5; 3-(6,7,8,9,10,11-Hexahydro-5H-Cycloocta[b]Indol-5-yl)-N,N-Dimethylpropan-1-Amine

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CAS号1556-09-8 溴代环辛烷 | CAS号369-57-3 四氟硼酸重氮苯盐 | CAS号109-54-6 3-氯-1-(N,N-二甲基)丙胺 | CAS号22793-63-1 6,7,8,9,10,11-六...

📜(6Z,10Z)-5-Tosyl-8,9-Dihydro-5H-Cycloocta[b]Indole置于乙醇,Palladium 10% On Activated Carbon,Potassium Tert-Butylate,氢气,四丁基碘化铵,Potassium Hydroxide体系中,用 乙酸乙酯,N,N-二甲基甲酰胺 作为反应溶剂,20.0~120.0 °C,1.01 Mpa 条件下,反应 87.5H,反应生成 伊普吲哚
参考文献:将八元环安装到indoles上的一锅法
标题:将八元环安装到indoles上的一锅法
摘要:环融合:2-烯丙基-3-碘-1--1-甲苯磺酰基-1 H-吲哚与炔丙基溴的pd 0催化反应可得到二氢环辛八烯[B]吲哚(参见示意图; Ms =分子筛,Tfp = Tris(2−呋喃基膦,Ts = 4-甲苯甲磺酰基),并通过碳-碳偶合,[1,5]-氢迁移和电环化进行.新建立的方法用于有效地访问艾普琳.
DOI:10.1002/anie.201202971

专利信息

专利号:US-7576211-B2
优先权日:2004-09-30
标题 :Synthesis of thienopyridinone compounds and related intermediates
发明人：DHANOA DALE S; BECKER OREN; NOIMAN SILVIA; CHEN DONGLI; MARANTZ YAEL; SHACHAM SHARON; HEIFETZ ALEXANDER; INBAL BOAZ; BAR-HAIM SHAY; MOHANTY PRADYUMNA; LOBERA MERCEDES; WU LAURENCE
权利人:EPIX DELAWARE INC
摘要:The invention relates to 5-HT receptor agonists and partial agonists. Novel thienopyridinone compounds represented by Formula I, and synthesis and uses thereof for treating diseases mediated directly or indirectly by 5-HT receptors, are disclosed. Such conditions include Alzheimer's disease, cognition disorders, irritable bowel syndrome, nausea, emesis, vomiting, prokinesia, gastroesophageal reflux disease, nonulcer dyspepsia, depression, anxiety, urinary incontinence, migraine, arrhythmia, atrial fibrillation, ischemic stroke, gastritis, gastric emptying disorders, feeding disorders, gastrointestinal disorders, constipation, erectile dysfunction, and respiratory depression. Methods of preparation and novel intermediates and pharmaceutical salts thereof are also included.

专利号:US-2008214827-A1
优先权日:2004-02-03
标 题:Synthesis of Cyanoimino-Benzoimidazoles
发明人：GOEHRING R RICHARD; WHITEHEAD JOHN; SHAO BIN
权利人:EURO CELTIQUE SA
摘要:Disclosed in certain embodiments is a process for synthesizing a compound of formula (V) and salts thereof.

专利号:US-7309799-B2
优先权日:2004-06-01
标 题:Methods for the synthesis of milnacipran and congeners thereof
发明人：BUCHWALD STEPHEN L; SWAGER TIMOTHY M; RARIY ROMAN V
权利人:COLLEGIUM PHARMACEUTICAL INC
摘要:One aspect of the present invention relates to methods for synthesizing milnacipran or congeners thereof. Another aspect of the present invention relates to asymmetric methods for synthesizing enantiomerically enriched milnacipran or congeners thereof. The present invention also relates to methods for synthesizing intermediates useful in the non-asymmetric or asymmetric methods for synthesizing enantiomerically enriched milnacipran or congeners thereof.

专利号:CN-102675186-A
优先权日:2012-05-24
标 题 :Indolo eight-membered ring diene compound, its synthesis method and its application in the synthesis of iprindole

专利号:CN-102675186-B
优先权日:2012-05-24
标题 :Indolo eight-membered ring diene compound, its synthesis method and its application in the synthesis of iprindole

专利号:WO-2008084057-A1
优先权日:2007-01-10
标题:Compounds with a combination of cannabinoid-cb1 antagonism and serotonin reuptake inhibition
发明人：LANGE JOSEPHUS H M; KRUSE CORNELIS G
权利人:SOLVAY PHARM BV; LANGE JOSEPHUS H M; KRUSE CORNELIS G
摘要:This invention relates to compounds with a combination of cannabinoid-CB1antagonism and serotonin reuptake inhibition to pharmaceutical compositions containing these compounds, to methods for preparing the compounds, methods for preparing novel intermediates useful for their synthesis, and methods for preparing compositions. The invention also relates to the uses of such compounds and compositions, particularly their use in administering them to patients to achieve a therapeutic effect in psychosis, anxiety, depression, attention deficits, cognitive disorders, obesity, drug dependence, Parkinson's disease, Alzheimer's disease, pain disorders, neuropathic pain disorders and sexual disorders. In particular the invention relates to compoundsof the general formula (I): wherein the symbols have the meanings given in the specification.