CAS: 481-18-5; (3S,5S,9R,10S,13R,14R,17R)-17-[(E,2R,5S)-5-Ethyl-6-Methylhept-3-En-2-Yl]-10,13-Dimethyl-2,3,4,5,6,9,11,12,14,15,16,17-Dodecahydro-1H-Cyclopenta[a]Phenanthren-3-Ol

上下游产品

24-ethly-5α-cholesta-7-22(E)-dien-3-one aluminum isopropoxide isopropyl alcohol benzene(S)-2-ethyl-3-methylbutanal 5α-Stigmast-8(14)-en-3β-ol 5α-stigmastan-3β-ol 5α-Stigmast-7,22-dien-3β-ol acetat

📜豆甾醇置于叔丁基过氧化氢,Di-μ-Hydroxo-Bis[(N,N,N',N'-Tetramethylethylenediamine)Copper(II)] Chloride,Palladium 10% On Activated Carbon,甲酸铵,Lithium Hydride体系中,用 四氢呋喃,甲醇,癸烷,二氯甲烷,乙酸乙酯,甲苯 作为反应溶剂,化学反应 49.0H,反应生成 A-波菜甾醇
参考文献:迅速合成菠菜甾醇和舒腾醇,坚果油和仙人掌梨子籽油中存在的两种植物甾醇,并评估它们对中枢神经系统细胞的生物学活性.
标题:迅速合成菠菜甾醇和舒腾醇,坚果油和仙人掌梨子籽油中存在的两种植物甾醇,并评估它们对中枢神经系统细胞的生物学活性.
摘要:菠菜甾醇和叔丁醇,存在于摩洛哥坚果油和仙人掌梨种子油中的两种植物甾醇,是通过四步反应从市售的豆甾醇中合成的.此外,分别用结晶紫试验和mtt试验评价了158N鼠少突胶质细胞,C6大鼠神经胶质瘤细胞和sk-N-Be人神经元细胞对这些植物甾醇对细胞生长和线粒体活性的影响.比较了spinasterol和schottenol与7-Ketocholesterol(7Kc)和阿魏酸的作用,阿甘和仙人掌梨种子油中也存在阿魏酸.无论考虑哪种细胞,均观测到了7Kc的剂量依赖性细胞毒性作用,而未发现或仅存在阿魏酸的轻微作用.用菠菜甾醇和舒腾醇,未检测到或对细胞生长有轻微影响.与菠菜甾醇,在158N和c6细胞上发现线粒体活性降低(30-50%);没有发现对sk-N-Be有影响.使用舒腾醇后,在158N(50%)和c6(10-20%)细胞上线粒体活性降低.没有发现对sk-N-Be有影响.总而言之,这些数据表明,菠菜
DOI:10.1016/j.Steroids.2015.01.005

专利信息

专利号:US-2025049714-A1
优先权日:2021-12-09
标题 :Synthesis of ester, carbonate, and carbamate-derived novel biodegradable ionizable lipids from methyl ricinoleate or methyl 12-hydroxystearate and its applications
发明人：ANDERSON DANIEL GRIFFITH; RHYM LUKE HYUNSIK; LI BOWEN; GORDON AKIVA; RAJITH SINGH MANAN; WITTEN JACOB
权利人:MASSACHUSETTS INST TECHNOLOGY
摘要:Provided herein are compounds, such as compounds of Formula (I), and pharmaceutically acceptable salts, hydrates, solvates, polymorphs, co-crystals, tautomers, stereoisomers, and isotopically labeled derivatives thereof, and compositions, methods, uses, and kits thereof. The compounds provided herein are lipids useful for delivery of polynucleotides, such as mRNA, for the treatment and/or prevention of various diseases and conditions (e.g., genetic disease, proliferative disease, hematological disease, neurological disease, liver disease, spleen disease, lung disease, painful condition, psychiatric disorder, musculoskeletal disease, a metabolic disorder, inflammatory disease, or autoimmune disease).

专利号:US-2024226302-A1
优先权日:2022-12-27
标题:Biodegradable lipids and formulations for intramuscular, in vitro, and ex vivo transfection of mrna
发明人：ANDERSON DANIEL GRIFFITH; RUDRA AMAB; GUPTA AKASH; REED KAELAN
权利人:MASSACHUSETTS INST TECHNOLOGY; CHILDRENS MEDICAL CENTER
摘要:Provided herein are compounds, such as compounds of Formula (I), and pharmaceutically acceptable salts thereof, and compositions, methods, uses, and kits thereof. The compounds provided herein are lipids useful for delivery of agents, including polynucleotides such as mRNA, for the treatment and/or prevention of various diseases and conditions (e.g., genetic diseases, proliferative diseases, hematological diseases, neurological diseases, liver diseases, spleen diseases, lung diseases, painful conditions, psychiatric disorders, musculoskeletal diseases, metabolic disorders, inflammatory diseases, and autoimmune diseases). Also provided herein are methods of synthesis of compounds of Formulae (I) and (II).

专利号:US-2025205158-A1
优先权日:2023-12-26
标 题 :Biodegradable lipids and formulations for delivery of mrna
发明人：ANDERSON DANIEL GRIFFITH; RUDRA ARNAB; GUPTA AKASH; REED KAELAN
权利人:MASSACHUSETTS INST TECHNOLOGY; CHILDRENS MEDICAL CENTER
摘要:Provided herein are compounds, such as compounds of Formulae (I), (I′), (XI), (XII), and (XIII), and pharmaceutically acceptable salts, solvates, tautomers, stereoisomers, and isotopically labeled derivatives thereof, and compositions, methods, uses, and kits thereof. The compounds provided herein are lipids useful for delivery of agents, including polynucleotides such as mRNA, for the treatment and/or prevention of various diseases and conditions (e.g., genetic diseases, proliferative diseases, hematological diseases, neurological diseases, liver diseases, spleen diseases, lung diseases, painful conditions, psychiatric disorders, musculoskeletal diseases, metabolic disorders, inflammatory diseases, and autoimmune diseases). Also provided herein are methods of synthesis of compounds of Formulae (I′), (XI), (XII), (XIII), and (VIII).

专利号:US-2016271177-A1
优先权日:2015-03-18
标 题:Process for bio synthesis of nano arsenic trioxide and its use in treatment of diseases including cancer

专利号:EP-2897906-A1
优先权日:2012-09-20
标 题:Process for bio synthesis of nano arsenic trioxide and its use in treatment of diseases including cancers

专利号:EP-2897906-B1
优先权日:2012-09-20
标题 :Process for bio synthesis of nano arsenic trioxide and its use in treatment of diseases including cancers
发明人：BENDALE YOGESH NARAYAN; BENDALE VINEETA YOGESH
权利人:BENDALE YOGESH NARAYAN; BENDALE VINEETA YOGESH