CAS: 475-25-2; 3,4,6A,10-Tetrahydroxy-6,7-Dihydroindeno[2,1-C]Chromen-9-One
该化合物是血氧素的化学化合物,一种天然染色素,摘自树脂Haematoxylum campechianum,主要以其在生物和医学实验室中用作病理学上的污点,特别是用于组织部分中的细胞核素污点.在氧化后,Hematein展示了深蓝色至紫色,这提高了显微镜下细胞结构的可见度.该化合物在酒精和水中溶解,能够适应各种染色议定书.Hematein功能与核酸结合,允许在微微镜检查中区分细胞成分.此外,重要的是要谨慎地处理 hematein,因为它可能是潜在的刺激因素.其应用范围超越了生物化学学和分子生物学等各个领域的应用,它有助于细胞形态学和病理学的直观化.总的来说, hematein是科学研究和诊断中的宝贵工具.
- 英文名称3,4,6A,10-Tetrahydroxy-6,7-Dihydroindeno[2,1-C]Chromen-9-One
- 中文名称氧化苏木精
- IUPAC名称3,4,6a,10-tetrahydroxy-6a,7-dihydroindeno[2,1-c]chromen-9(6H)-one
- 其它别名Hematein(6CI); Haematein; Hematine
- CAS编号475-25-2
- MFCD编号:MFCD00036187
- EINECS号:207-492-8
- FDA UNII编号:88Q1SYD10B
- 分子式:C16H12O6分子量:300.26
- 产品CID: 1468844
- 同类组份化合物CAS475-25-2 (hematein)517-28-2 (hematoxylin)
- 产品分类有机原料 → 有机杂环化合物 → 苯并吡喃
物理性质
- 熔点180 °C
- 沸点753.1 °C at 760mmHg
- 闪点289 °C
- 密度1.77g/cm3
- pKa:8.02±0.40(预测)
- PSA:107.22
- LogP:1.3296
- 折射率1.765
- 蒸汽压1.32E-17mmHg at 25°C
- 溶解性Methanol (Slightly)
- 外观形态深棕色结晶粉末
- 储存条件2-8°C
- 产品应用HEMATEIN (一种乙氧氧化产品) 显示主要通过体细胞2 (CK2) 抑制来显示抗癌生物活性. 在体外, 肝内酯以非竞争方式抑制CK 2 活动, 报告的IC50 = 0.55-0.74 ΜM , 并抑制下游信号, 如 AKT/PKB SER129 磷酸化, 以及肺癌细胞模型中的抗生素效应. 在体内, HEMATEIN 显示肿瘤生长抑制, 与 CK2 路径抑制一致(报告的为肿瘤增量减少相对于被治疗的老鼠的控制) . 这一产品纯度较低(估计的HPLC 纯度约为 50%).
上下游产品
Hematoxylin 17647-60-8合成工艺路线路线简述
📜Alkaline Earth Salt Of/the/ Methylsulfuric Acid置于碘,Mercury(II) Oxide体系中,化学反应生成 氧化苏木精
参考文献:Weselsky,Justus Liebigs Annalen Der Chemie,1874,Vol. 174,P. 100
标题:Weselsky,Justus Liebigs Annalen Der Chemie,1874,Vol. 174,P. 100
海关参考信息
- 2901210000-乙烯
2901220000-丙烯
2901241000-1,3-丁二烯
2902500000-苯乙烯 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-2023097824-A1
优先权日:2020-05-08
标 题:Semi-synthesis and use of racemic hematoxylin
发明人：DURRANT EDWARD E; HEINDL DIETER; HUBER FLORIAN MAURITIUS ERASUMU; KLEIN ERIC; KOSMEDER II JEROME W; VOSS EDGAR
权利人:VENTANA MED SYST INC; ROCHE DIAGNOSTICS OPERATIONS INC
摘要:A racemic hematoxylin formulation is disclosed that includes one or both of a stabilizer compound and an antioxidant. The disclosed composition exhibits sufficient stability to be utilized in an automated staining process. Methods of using and making the stabilized composition also are disclosed.
专利号:US-10772990-B2
优先权日:2014-04-01
标题 :Tissue filler compositions and methods of use
发明人：NIKOLIS ANDREAS; HERBERT LISE
权利人:KLOX TECH INC
摘要:The present disclosure relates to methods for stimulating collagen synthesis, cosmetic enhancement of soft tissue and/or inhibiting or treating scarring comprising administering a composition to an area to be treated within a soft tissue, wherein the composition comprises a tissue filler medium and a fluorophore; and illuminating the area with light having a wavelength which can be absorbed by the fluorophore.
专利号:US-2003186237-A1
优先权日:2001-02-14
标题:Methods and compositions of amplifying RNA
发明人：GINSBERG STEPHEN D; CHE SHAOLI
权利人:BAYLOR COLLEGE MEDICINE
摘要:The present invention pertains to a method that will increase the efficiency of second strand cDNA synthesis through a mechanism of “terminal continuationâ€? before further RNA amplification by RNA transcription using, for example, a bacteriophage promoter. In a specific embodiment, a transcription promoter is attached to the 5′ region of cDNA through the same mechanism of “terminal continuationâ€?. Genetic signals are subsequently amplified in a linear manner through RNA transcription. In specific embodiments, the orientation of the transcribed RNA is either sense or antisense, depending on the desired downstream application. In other embodiments, the present invention pertains to methods for extraction and amplification of RNA, particularly mRNA, from histologically stained tissues and cells.
专利号:WO-2021224361-A2
优先权日:2020-05-08
标题 :Semi-synthesis and use of racemic hematoxylin
专利号:CN-115612114-A
优先权日:2021-07-14
标 题:Method and application of copolymer film and its enzymatic self-assembly synthesis
专利号:EP-4147024-A2
优先权日:2020-05-08
标 题:Semi-synthesis and use of racemic hematoxylin
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
1: Pengsawang M, Toviwek B, Sangthong W, Boonmee A, Chairatana P, Pongprayoon P. The binding modes of brazilin and hematein from Caesalpinia sappan L. to Cutibacterium acnes lipase: Simulation studies. PLoS One. 2025 Mar 4;20(3):e0318706. doi: 10.1371/journal.pone.0318706.
2: Gersing AS, Kimm MA, Bollwein C, Ilg P, Mogler C, Gassert FG, Feuerriegel GC, Knebel C, Woertler K, Pfeiffer D, Busse M, Pfeiffer F. Chondrosarcoma evaluation using hematein-based x-ray staining and high-resolution 3D micro-CT: a feasibility study. Eur Radiol Exp. 2024 May 13;8(1):58. doi: 10.1186/s41747-024-00454-0.
3: Wang R, Wang J, Ding N, He S, Zhao Y, Gao P. Effects of okadaic acid and hematein on human lung adenocarcinoma A549 cells and responses of mitochondria and endoplasmic reticulum apoptosis pathways. Transl Cancer Res. 2019 Jun;8(3):968-975. doi: 10.21037/tcr.2019.06.05.
合成参考文献
参考文献:10.1007/bf01952324
摘要:Pechan P, Tracey M. H-Y Evolution. Cellular and Molecular Life Sciences. 1980 Mar;36(3):356–7. doi: 10.1007/bf01952324.
参考文献:10.1007/bf02830715
摘要:Cao Y, Wei H, Pfaffl M, Da B, Li Z. Apoptosis of human trabecular meshwork cells induced by transforming growth factor-beta2 in vitro. J Huazhong Univ Sci Technolog Med Sci. 2004;24(1):87–9, 94. doi: 10.1007/bf02830715.
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