CAS: 34981-26-5; (S)-2-(2,4-Dihydroxyphenyl)-7-Hydroxy-5-Methoxy-8-((R)-5-Methyl-2-(Prop-1-En-2-yl)Hex-4-En-1-yl)Chroman-4-One
该化合物是一种主要与传统药用植物Sophora Flavescens的根部分离的生物活性花草类化合物,它具有显著的药理特性,包括抗炎,抗氧化剂和抗直肠活动. Kurarinone研究其调制NF-B和MAPK等信号路径的潜力,使其成为慢性炎病和癌症治疗应用的候选体.它抑制病毒复制的能力,特别是抑制乙型和丙型肝炎的病毒复制,进一步强调了其生物医学相关性.该化合物独特的化学结构,其特征是前乳胶叶片骨干,有助于其稳定性和生物利用率. Kurarinone被广泛用于药物开发和机械学研究.
- 英文名称(S)-2-(2,4-Dihydroxyphenyl)-7-Hydroxy-5-Methoxy-8-((R)-5-Methyl-2-(Prop-1-En-2-yl)Hex-4-En-1-yl)Chroman-4-One
- 中文名称苦参酮
- IUPAC名称(S)-2-(2,4-dihydroxyphenyl)-7-hydroxy-5-methoxy-8-((R)-5-methyl-2-(prop-1-en-2-yl)hex-4-en-1-yl)chroman-4-one
- 其它别名KURARINONE; 2-(2,4-Dihydroxyphenyl)-2,3-dihydro-7-hydroxy-5-methoxy-8-[5-methyl-2-(1-methylethenyl)-4-hexenyl]-4H-1-benzopyran-4-one
- CAS编号34981-26-5
- MFCD编号:MFCD21333215
- 分子式:C26H30O6分子量:438.52
- 产品CID: 1354730
- 产品分类天然产物 → 黄酮类化合物
物理性质
- 熔点117-119 °C
- 沸点651.4±55.0 °C at 760 mmHg
- 闪点219.0±25.0 °C
- 密度1.2±0.1 g/cm3
- pKa:7.49±0.40(预测)
- PSA:96.22
- LogP:6.3
- 折射率1.597
- 蒸汽压0.0±2.0 mmHg at 25°C
- 溶解性Soluble In Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,Etc.
- 外观形态淡黄色至黄色粉末
- 储存条件-20°C
- 产品应用该化合物是一种先发制人,先发型的氟氯素化合物,主要与东亚传统医药中所使用的植物SOPHORA FLAVESCENS(SOPHERA FLAVESSENS)的根部隔离. 它展示了显著的生物活性,包括抗炎,抗癌,抗氧化剂和抗微生物效应. KURRAINONE的行动机制因背景而异,但往往包括抑制NF-NB和MAPK信号路径,抑制亲炎细胞细胞细胞,以及通过线粒体机能功能障碍和松酶活化在癌症细胞中诱发流行.
MSDS等安全信息
合成工艺路线路线简述
海关参考信息
- 2901210000-乙烯
2901220000-丙烯
2902600000-乙苯
2905121000-正丙醇 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:BR-102013004095-A2
优先权日:2013-02-14
标 题:METHOD OF SYNTHESIS OF CRYOLITE FROM LODE OF WATER TREATMENT STATIONS
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
1. Nishikawa S, Itoh Y, Tokugawa M, Inoue Y, Nakashima KI, Hori Y, Miyajima C, Yoshida K, Morishita D, Ohoka N, Inoue M, Mizukami H, Makino T, Hayashi H. Kurarinone from Sophora Flavescens Roots Triggers ATF4 Activation and Cytostatic Effects Through PERK Phosphorylation. Molecules. 2019 Aug 27;24(17):3110. doi: 10.3390/molecules24173110. 2. Chung TW, Lin CC, Lin SC, Chan HL, Yang CC. Antitumor effect of kurarinone and underlying mechanism in small cell lung carcinoma cells. Onco Targets Ther. 2019 Aug 5;12:6119-6131. doi: 10.2147/OTT.S214964. 3. Qin Y, Zhu Y, Xue X, Zhou G, Li H, Wang J. An In Vitro Study for Evaluating Permeability and Metabolism of Kurarinone. Evid Based Complement Alternat Med. 2020 Sep 13;2020:5267684. doi: 10.1155/2020/5267684. 4. Xie L, Gong W, Chen J, Xie HW, Wang M, Yin XP, Wu W. The flavonoid kurarinone inhibits clinical progression of EAE through inhibiting Th1 and Th17 cell differentiation and proliferation. Int Immunopharmacol. 2018 Sep;62:227-236. doi: 10.1016/j.intimp.2018.06.022. Epub 2018 Jul 20.9:252. doi: 10.3389/fphar.2018.00252. 6. Zhou W, Cao A, Wang L, Wu D. Kurarinone Synergizes TRAIL-Induced Apoptosis in Gastric Cancer Cells. Cell Biochem Biophys. 2015 May;72(1):241-9. doi: 10.1007/s12013-014-0444-0.
合成参考文献
参考文献:10.1055/s-2005-871302
摘要:Hillerns PI, Wink M. Binding of flavonoids from Sophora flavescens to the rat uterine estrogen receptor. Planta Med. 2005 Nov;71(11):1065–8. doi: 10.1055/s-2005-871302.
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