CAS: 321921-71-5; Di(Adamantan-1-yl)(Butyl)Phosphine

上下游产品

tert.-butyl lithium di-1-adamantylchlorophosphane (1-adamantyl)magnesium chloride (1-adamantyl)dichlorophosphine4H9)(C10H15)2)2(C6H4CF3)PdBr(P(C4H9)(C10H15)2)2(C6H4CF3) chloro[(di(1-adamantyl)-N-butylphosphine)-2-(2-aminobiphenyl)]palladium(II) 2-[3-(9,9-dimethyl-9H-fluoren-2-yl)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

双(1-金刚烷基)氯化磷置于正丁基锂体系中,用 四氢呋喃,正己烷 用作溶剂,化学反应生成正丁基二(1-金刚烷基)膦
参考文献:Production Of Novel Phosphane Ligands And Use In Catalytical Reactions
标题:Production Of Novel Phosphane Ligands And Use In Catalytical Reactions
摘要:该发明涉及公式(Ia)和(Ib)的新型膦配体:(脱氢胆固醇)Np(烷基)M(1A);(脱氢胆固醇)O(烷基)Qp(烷基)P(脱氢胆固醇)R(烷基)S(1B),其中脱氢胆固醇代表与磷原子在1或2位置结合的脱氢胆固醇基团(Iia,Iib).该发明还涉及在第8周期元素周期表的过渡金属化合物存在下制备和使用上述配体,特别用于催化反应,尤其用于精炼卤代芳烃以生产芳基烯烃,二烯烃,二芳基烯,苯甲酸和丙烯酸衍生物,芳基烷烃以及胺类.

专利信息

专利号:WO-2025119975-A1
优先权日:2023-12-04
标 题:A method for synthesis of harmine
发明人：HETT ROBERT; GRAB HANUSCH; LAGOUTTE ROMAN
权利人:RECONNECT LABS AG
摘要:The invention relates to a method of synthesis of a compound of formula (I), harmine, according to the method comprising a step of transforming the compound of formula (II), into the compound of formula (I). The invention further relates to a compound of formula (II), which is an intermediate in synthesis of harmine according to the present invention.

专利号:US-12162849-B2
优先权日:2018-12-21
标题 :Synthesis of 3-methyl-1,2,4-thiadiazole-5-carbohydrazide or of the methyl-d3 deuterated form thereof
发明人：HOVEYDA HAMID; DUTHEUIL GUILLAUME
权利人:OGEDA SA
摘要:The present invention relates to a method of synthesis of compound (I), wherein R1 represents methyl or methyl-d3, thus corresponding to 3-methyl-1,2,4-thiadiazole-5-carbohydrazide or to the methyl-d3 deuterated form thereof. These compounds are useful as key intermediates in the synthesis of pharmaceutical compounds, especially fezolinetant and deuterated fezolinetant.

专利号:US-9212118-B2
优先权日:2010-12-23
标题:Synthesis of intermediates for preparing anacetrapib and derivatives thereof
发明人：HUMLJAN JAN; MARAS NENAD
权利人:HUMLJAN JAN; MARAS NENAD; LEK PHARMACEUTICALS
摘要:The present invention relates to the field of organic chemistry, more specifically to the synthesis of intermediate compounds which can be used in the synthesis of pharmaceutically active agents such as anacetrapib or derivatives thereof.

专利号:WO-2024260325-A1
优先权日:2023-06-19
标题 :Synthesis of macrocyclic compound and medical use of macrocyclic compound
发明人：LU HONGFU; DING XIAO; REN FENG
权利人:INSILICO MEDICINE IP LTD
摘要:Provided in the present invention are the synthesis of a macrocyclic compound and the medical use of the macrocyclic compound. Specifically, provided in the present invention are a compound as show in formula (II), a stereoisomer thereof or a pharmaceutically acceptable salt thereof, which can be used as a CDK7 inhibitor.

专利号:EP-2103609-A1
优先权日:2008-03-20
标 题:Catalyzed carbonylation in the synthesis of angiotensin ii antagonists
权利人:LEK PHARMACEUTICALS
摘要:One embodiment disclosed in the invention is the efficient synthesis of halogenated biaryl starting material via Grignard chemistry and the use thereof. Another embodiment of the invention is the reaction of catalyzed carbonylation of the 3'-(2'-halo-biphenyl-4-ylmethyl)-1,7'-dimethyl-2'-propyl-1H,3'H-[2,5']bibenzoimidazolyl (TLMH) using either gaseous carbon monoxide in a solvent mixture containing water; or formic acid salts optionally together with acetic acid in anhydrous solvent.

专利号:US-8445693-B2
优先权日:2008-03-20
标 题 :Catalyzed carbonylation in the synthesis of angiotensin II antagonists
发明人：CASAR ZDENKO; COPAR ANTON; CLUZEAU JEROME; PREMRL ANDREJ
权利人:CASAR ZDENKO; COPAR ANTON; CLUZEAU JEROME; PREMRL ANDREJ; LEK PHARMACEUTICALS
摘要:One embodiment disclosed in the invention is the efficient synthesis of halogenated biaryl starting material via Grignard chemistry and the use thereof. Another embodiment of the invention is the reaction of catalyzed carbonylation of the 3′-(2′-halo-biphenyl-4-ylmethyl)-1,7′-dimethyl-2′-propyl-1H,3′H-[2,5′]bibenzoimidazolyl (TLMH) using either gaseous carbon monoxide in a solvent mixture containing water; or formic acid salts optionally together with acetic acid in anhydrous solvent.