CAS: 30766-12-2; Methyl 5-Hydroxypyridine-2-Carboxylate

该化合物是一种有机化合物,其特点是其丙烯环结构,这是一个六人组成的芳香环,内含一个氮原子.该化合物的特点是一个碳boxylic酸功能组(EuroCOOH),该组因一个乙醇组(EuroOCH3)而进入甲基酯形态.在五处放置的丙烯环上存在一个氢氧基(EuroHOH),这组(EuroOH),这组会助长其极性以及氢联结潜力,影响极地溶剂中的溶性.该化合物一般是白色至非白固体,在标准条件下可能具有中的稳定性.由于它的潜在生物活动,它涉及各个领域,包括药品和农用化学品.与许多有机化合物一样,必须谨慎处理它,并遵循适当的安全议定书,以减少与使用它有关的任何风险.

结构式图片

相似化合物

15069-92-8 31191-08-9 40222-77-3

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CAS号67-56-1 甲醇 | CAS号15069-92-8 5-羟基-2-吡啶羧酸 | CAS号74386-59-7 5-benzyloxy-2-p... | CAS号64-17-5 乙醇 | CAS号29082-92-6 5-甲氧基吡啶-2-羧酸 | CAS号4833-91-4 5-磺酸基吡啶-2-羧酸 | CAS号29681-39-8 5-甲氧基吡啶-2-甲酸甲酯 | CAS号72133-20-1 5-(3-chloroprop... | CAS号74386-57-5 5-(3-chloroprop... | CAS号856835-98-8 2-Pyridinecarbo... | CAS号64354-26-3 4,6-二溴-5-羟基吡啶甲酸

合成工艺路线路线简述

    📜5-磺酸基吡啶-2-羧酸置于盐酸,甲醇,Sodium Hydroxide,水体系中,化学反应生成 5-羟基-2-吡啶甲酸甲酯
    参考文献:Heyns; Vogelsang,Chemische Berichte,1954,Vol. 87,P. 13,18
    标题:Heyns; Vogelsang,Chemische Berichte,1954,Vol. 87,P. 13,18

    海关参考信息

    专利信息


    专利号:US-9771379-B2
    优先权日:2015-09-24
    标题:N-(2-(2-amino-6-substituted-4,4a,5,6-tetrahydropyrano[3,4-d][1,3]OXAZIN-8a(8H)-yl)-thiazol-4-yl) amides
    发明人:BRODNEY MICHAEL AARON; BUTLER CHRISTOPHER RYAN; ZHANG LEI; O'NEILL BRIAN THOMAS
    权利人:PFIZER
    摘要:The present invention is directed to compounds, tautomers and pharmaceutically acceptable salts of the compounds which are disclosed, wherein the compounds have the structure of Formula I, n nwherein the variables R 1 , R 2 , R 3 , R 4 and X are as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

    专利号:US-9744173-B2
    优先权日:2014-04-10
    标题 :2-amino 6-methyl-4,4a,5,6-tetrahydropyrano[3,4-d][1,3]thiazin-8a(8H)-yl-1,3-thiazol-4-yl amides
    发明人:BRODNEY MICHAEL AARON; BECK ELIZABETH MARY; BUTLER CHRISTOPHER RYAN; ZHANG LEI; O'NEILL BRIAN THOMAS; BARREIRO GABRIELA; LACHAPELLE ERIK ALPHIE; ROGERS BRUCE NELSEN
    权利人:PFIZER
    摘要:The present invention is directed to compounds, tautomers and pharmaceutically acceptable salts of the compounds which are disclosed, wherein the compounds have the structure of Formula I, n nand the variable R 1 is as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

    专利号:US-9751895-B2
    优先权日:2015-09-24
    标 题:N-[2-(2-amino-6,6-disubstituted-4,4a,5,6-tetrahydropyrano[3,4-d][1,3]thiazin-8a(8H)-yl)-1,3-thiazol-4-yl]amides
    发明人:BRODNEY MICHAEL AARON; BUTLER CHRISTOPHER RYAN; ZHANG LEI; O'NEILL BRIAN THOMAS; VERHOEST PATRICK ROBERT; MIKOCHIK PETER JUSTIN; MURRAY JOHN CHARLES; HOU XINJUN
    权利人:PFIZER
    摘要:The present invention is directed to compounds, tautomers and pharmaceutically acceptable salts of the compounds which are disclosed, wherein the compounds have the structure of Formula I, n nand the variables R 1 , R 2 and R 3 are as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

    专利号:US-9611264-B1
    优先权日:2015-09-24
    标 题:N-[2-(3-amino-2,5-dimethyl-1,1-dioxido-5,6-dihydro-2H-1,2,4-thiadiazin-5-yl)-1,3-thiazol-4-yl] amides
    发明人:BRODNEY MICHAEL AARON; BUTLER CHRISTOPHER RYAN; ZHANG LEI; O'NEILL BRIAN THOMAS; VERHOEST PATRICK ROBERT; SALOMON FERRER ROMELIA DEL CARMEN
    权利人:PFIZER
    摘要:The present invention is directed to compounds, tautomers and pharmaceutically acceptable salts of the compounds which are disclosed, wherein the compounds have the structure of Formula I, n n n n n n n n n n n n wherein the variables R 1 , R 2 and R 3 are as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

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    品牌试剂参考报价(招募中)

    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    主要参考文献

    [参考文献]: Liu L, Et, Al. Simultaneous Characterisation Of Multiple Mahonia Fortunei Bioactive Compounds In Rat Plasma By Uplc-Ms/ms For Application In Pharmacokinetic Studies And Anti-Inflammatory Activity In Vitro. J Pharm Biomed Anal. 2020 Feb 5;179:113013.

    合成参考文献


    参考文献:10.1007/s10600-025-04572-y
    摘要:Yu J, Wang X, Botirov EK, Dong H, Gusakova SD, Liu W. Chemical Constituents from Achyranthes bidentata and Their Antihyperuricemic Acid Activities. Chem Nat Compd. 2025 Jan;61(1):52–5. doi: 10.1007/s10600-025-04572-y.
    摘要:Chen L, Song ZY, Wang JJ, Song HT, Zhang GG, Wang JH. [Studies on the chemical constituents from aerial parts of Gynura divaricata]. Zhong Yao Cai. 2010 Mar;33(3):373–6.
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