CAS: 205676-17-1; 2-(4-Chlorophenyl)Malonaldehyde

上下游产品

4-chlorophenylacetic Acid 4-(4-chlorophenyl)-1H-pyrazole 4-(4-chlorophenyl)-1-(4-nitrophenyl)-1H-pyrazole

📜对氯苯乙酸置于sodium Perchlorate Monohydrate,Sodium Hydroxide,三氯氧磷体系中,用 水 用作溶剂,化学反应 0.25H,反应生成2-(4-氯苯基)丙二醛
参考文献:新型4-吡唑基-1,8-萘二甲酰亚胺衍生物的合成,抗癌活性和dna结合特性
标题:新型4-吡唑基-1,8-萘二甲酰亚胺衍生物的合成,抗癌活性和dna结合特性
摘要:已经设计并容易地合成了一系列新颖的4-吡唑基-1,8-萘二甲酰亚胺衍生物.对于体外抗癌活性,发现大多数化合物对人乳腺癌细胞(mcf-7)的毒性比人宫颈癌细胞(hela)和人肺癌细胞(a549)高.化合物4I,4H,4B和4A与阿莫那肽相比对mcf-7细胞表现出改善的细胞毒活性,尤其是化合物4I和4H,其对mcf-7细胞系的ic 50值分别为0.51μm和0.79μm .4I的dna结合特性通过紫外可见光谱,荧光和圆二色性(cd)光谱学和热变性进行了研究.结果表明,作为dna嵌入剂的化合物4I显示出与ct-Dna的中等结合亲和力.
Doi:10.1016/j.Bmcl.2013.12.014

专利信息

专利号:US-11225655-B2
优先权日:2010-04-16
标题:Bi-functional complexes and methods for making and using such complexes
发明人：GOULIAEV ALEX HAAHR; FRANCH THOMAS; GODSKESEN MICHAEL ANDERS; JENSEN KIM BIRKEBAEK
权利人:GOULIAEV ALEX HAAHR; FRANCH THOMAS; GODSKESEN MICHAEL ANDERS; JENSEN KIM BIRKEBAEK; NUEVOLUTION AS
摘要:The present invention is directed to a method for the synthesis of a bi-functional complex comprising a molecule part and an identifier oligonucleotide part identifying the molecule part. A part of the synthesis method according to the present invention is preferably conducted in one or more organic solvents when a nascent bi-functional complex comprising an optionally protected tag or oligonucleotide identifier is linked to a solid support, and another part of the synthesis method is preferably conducted under conditions suitable for enzymatic addition of an oligonucleotide tag to a nascent bi-functional complex in solution.