CAS: 19542-67-7; (E)-3-Tosylacrylonitrile
该化合物是一种有机化合物,具有独特的功能组和结构特征,含有一种蛋白质脊柱,这是一个共聚系统,具有双联和硝基联(-CN),附于一个准甲基苯基混合物的磺酰基(-SO2)组的存在,增强了其在各种有机溶剂中的再活性和溶性,这种化合物一般在室温下是固体,在标准条件下可能表现出中度至高度稳定,其化学特性受到硝基和磺基化合物的电镀性影响,可能影响其在核聚变反应中的再活动.此外,该化合物可能因其作为较复杂的分子的构件而具有应用有机合成和材料科学的潜力,因此在有机合成和材料科学中可能具有应用.
- 英文名称(E)-3-Tosylacrylonitrile
- 中文名称(E)-3-(对甲苯磺酰基)丙烯腈
- IUPAC名称(E)-3-tosylacrylonitrile
- 其它别名(E)-3-(4-METHYLPHENYLSULFONYL)-2-PROPENENITRILE; (2E)-3-[(4-METHYLPHENYL)SULFONYL]-2-PROPENENITRILE
- CAS编号19542-67-7
- MFCD编号:MFCD00712162
- EINECS号:805-917-7
- FDA UNII编号:4Y5G2A4F6O
- 分子式:C10H9NO2S分子量:207.25
- 产品CID: 992130
- 产品分类生物化工 → 抑制剂 → 核转录因子(NF→κB)
物理性质
MSDS等安全信息
欧盟法规
ECHA物质C&L通报上下游产品
CAS号824-79-3 对甲苯亚磺酸钠 | CAS号107-13-1 丙烯腈 | CAS号77825-72-0 2-(Phenylseleno... | CAS号151-50-8 氰化钾 | CAS号86409-95-2 (E)-1-(phenylse... | CAS号86409-89-4 (E)-1-(phenylse... | CAS号68819-94-3 Tosylphenyl selenide | CAS号1950-78-3 4-methylbenzene... | CAS号4554-16-9 2,3-二溴丙腈 | CAS号1950-69-2 4-甲基苯磺酰溴 | CAS号715-12-8 3-(4-methylphen...合成工艺路线路线简述
- 合成目标产物 Bay 11-7082 主要起始原料 Acrylonitrile And Tosyl Chloride
- (文献来源)合成步骤主要原料 Acrylonitrile 和 Tosyl Chloride
📜(E)-1-(Phenylseleno)-2-(P-Tolylsulfonyl)Ethene置于18-冠醚-6,间氯过氧苯甲酸体系中,用 四氢呋喃,二氯甲烷 用作溶剂,化学反应 2.25H,反应生成(E)-3-(对甲苯磺酰基)丙烯腈
参考文献:Substitution Reactions Of Carbon Nucleophiles With .Beta.-(Phenylseleno)Vinyl Sulfone Selenium Oxides
标题:Substitution Reactions Of Carbon Nucleophiles With .Beta.-(Phenylseleno)Vinyl Sulfone Selenium Oxides
摘要:
Doi:10.1021/jo00228A020
海关参考信息
- 2901210000-乙烯
2901220000-丙烯
2902300000-甲苯
2926100000-丙烯腈 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-6232467-B1
优先权日:1996-06-28
标 题:Method for the synthesis of amines and amino acids with organoboron derivatives
发明人：PETASIS NICOS A; ZAVIALOV ILIA A
权利人:UNIV SOUTHERN CALIFORNIA
摘要:Amines and amino acids are prepared by reacting an amine, a carbonyl derivative, and an organoboron compound under mild conditions.
专利号:WO-9800398-A1
优先权日:1996-06-28
标题 :Method for the synthesis of amines and amino acids with organoboron derivatives
专利号:EP-0923544-B1
优先权日:1996-06-28
标题:Method for the synthesis of amines and amino acids with organoboron derivatives
专利号:CA-2259203-C
优先权日:1996-06-28
标题 :Method for the synthesis of amines and amino acids with organoboron derivatives
专利号:US-9758826-B2
优先权日:2010-06-24
标题 :PUMA, a pro-apoptotic gene, as a novel molecular biomarker for TNFα-induced human islet damage
发明人：MULLEN YOKO; MITSUHASHI MASATO; OMORI KEIKO
权利人:MULLEN YOKO; MITSUHASHI MASATO; OMORI KEIKO; HOPE CITY; HITACHI CHEMICAL RES CENTER INC; HITACHI CHEMICAL CO LTD
摘要:p53-upregulated modulator of apoptosis (PUMA) is a biomarker associated with islet cell health. If PUMA is low, islet cells are typically healthy. If PUMA is high, islet cells are typically unhealthy or dying. PUMA may be measured by either measuring its nucleic or amino acid. PUMA mRNA may be induced by TNF-α stimulation in a time- and dose-dependent manner and β cell apoptosis is induced through a mitochondrial pathway. TNF-α significantly inhibited glucose-induced preproinsulin precursor mRNA synthesis. Such β cell stress signaling in human islets indicates overall state of islet health and, ultimately, the risk of onset and/or degree of severity of both type 1 and type 2 diabetes mellitus.
专利号:CN-110642803-B
优先权日:2019-10-25
标 题 :Synthesis method of dihydrothiazole heterocyclic compound and application of dihydrothiazole heterocyclic compound in modification of biological molecules
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
1: Kolati SR, Kasala ER, Bodduluru LN, Mahareddy JR, Uppulapu SK, Gogoi R, Barua CC, Lahkar M. BAY 11-7082 ameliorates diabetic nephropathy by attenuating hyperglycemia-mediated oxidative stress and renal inflammation via NF-κB pathway. Environ Toxicol Pharmacol. 2015 Mar;39(2):690-9. doi: 10.1016/j.etap.2015.01.019. Epub 2015 Feb 7. doi: 10.1007/s00535-013-0848-4. Epub 2013 Jul 12. doi: 10.1111/febs.12283. Epub 2013 May 9.
4: Rauert-Wunderlich H, Siegmund D, Maier E, Giner T, Bargou RC, Wajant H, Stühmer T. The IKK inhibitor Bay 11-7082 induces cell death independent from inhibition of activation of NFκB transcription factors. PLoS One. 2013;8(3):e59292. doi: 10.1371/journal.pone.0059292. Epub 2013 Mar 20.
5: Strickson S, Campbell DG, Emmerich CH, Knebel A, Plater L, Ritorto MS, Shpiro N, Cohen P. The anti-inflammatory drug BAY 11-7082 suppresses the MyD88-dependent signalling network by targeting the ubiquitin system. Biochem J. 2013 May 1;451(3):427-37. doi: 10.1042/BJ20121651.
合成参考文献
摘要:Kawęcki, R., Science of Synthesis Knowledge Updates, (2018) 4, 286.
参考文献:10.1016/j.toxlet.2006.04.007
摘要:Seok SM, Park DH, Kim YC, Moon CH, Jung YS, Baik EJ, Moon CK, Lee SH. COX-2 is associated with cadmium-induced ICAM-1 expression in cerebrovascular endothelial cells. Toxicol Lett. 2006 Sep 10;165(3):212–20. doi: 10.1016/j.toxlet.2006.04.007.
参考文献:10.1152/ajpgi.00537.2005
摘要:Sancho-Bru P, Bataller R, Colmenero J, Gasull X, Moreno M, Arroyo V, Brenner DA, Ginès P. Norepinephrine induces calcium spikes and proinflammatory actions in human hepatic stellate cells. American Journal of Physiology-Gastrointestinal and Liver Physiology. 2006 Nov;291(5):G877–84. doi: 10.1152/ajpgi.00537.2005.
参考文献:10.1007/s11010-011-0871-9
摘要:Shen X, Zhu W, Zhang X, Xu G, Ju S. A role of both NF-κB pathways in expression and transcription regulation of BAFF-R gene in multiple myeloma cells. Molecular and Cellular Biochemistry. 2011 May 24;357(1-2):21–30. doi: 10.1007/s11010-011-0871-9.
参考文献:10.1371/journal.pone.0051413
摘要:Peng B, Gu Y, Xiong Y, Zheng G, He Z. Microarray-Assisted Pathway Analysis Identifies MT1X & NFκB as Mediators of TCRP1-Associated Resistance to Cisplatin in Oral Squamous Cell Carcinoma. PLoS ONE. 2012 Dec 10;7(12):e51413. doi: 10.1371/journal.pone.0051413.
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